Quantitative Determination of 3-O-Acetyl-11-Keto-βBoswellic Acid (AKBA) and Other Boswellic Acids in Boswellia sacra Flueck (syn. B. carteri Birdw) and Boswellia serrata Roxb

Mannino, Giuseppe; Occhipinti, Andrea; Maffei, Massimo E.

doi:10.3390/molecules21101329

Cited by 53 publications

(40 citation statements)

References 29 publications

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“…The other components of BS extracts, lacking the keto moiety, were visualized only at a less specific wavelength (210 nm) as already reported [34]. The AKBA concentrations detected in samples A, B, D, and F are similar to those reported by other authors [30, 35], while those found in extracts C and G were 10 or 100 times lower, respectively. It can be hypothesized that extract C belongs to Boswellia species other than B. serrata , due to a wrong botanical identification by local producers.…”

Section: Discussionsupporting

confidence: 88%

Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts

Beghelli

Isani

Roncada

et al. 2017

Oxidative Medicine and Cellular Longevity

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Boswellia serrata (BS) is an important traditional medicinal plant that currently represents an interesting topic for pharmaceutical research since it possesses several pharmacological properties (e.g., anti-inflammatory, antimicrobial, and antitumour). The safety and versatility of this dietary supplement should allow for its use in numerous pathological conditions; however the quality of the extracts needs to be standardized to increase the clinical success rate resulting from its use. In the present study, different commercially available B. serrata extracts were employed to compare their AKBA content and in vitro antioxidant power. Furthermore, their ability to modulate the immune system regulatory properties was investigated. Our results showed that the AKBA content varied from 3.83 ± 0.10 to 0.03 ± 0.004%, with one sample in which it was not detectable. The highest antioxidant power and phenolic content were shown by the same extract, which also exhibited the highest AKBA concentration. Finally, the BS extracts showed the ability to influence the regulatory and effector T-cell compartments. Our results suggest that frankincense should be further investigated for its promising potentiality to modulate not only inflammation/oxidative stress but also immune dysregulation, but attention should be paid to the composition of the commercial extracts.

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Section: Discussionsupporting

confidence: 88%

Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts

Beghelli

Isani

Roncada

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Moreover, HPLC–DAD coupled with MS is usually used for the qualitative and quantitative determination of pentacyclic triterpenoids . Mannino et al.…”

Section: Discussionmentioning

confidence: 99%

“…Mannino et al. utilized HPLC–DAD–MS to quantitatively determinate the content of boswellic acids in Boswellia sacra Flueck and Boswellia serrata Roxb . Lu et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Hplc With Diode-array Detectionmentioning

confidence: 99%

“…Moreover, HPLC-DAD coupled with MS is usually used for the qualitative and quantitative determination of pentacyclic triterpenoids [17,26,27,96]. Mannino et al utilized HPLC-DAD-MS to quantitatively determinate the content of boswellic acids in Boswellia sacra Flueck and Boswellia serrata Roxb [96]. Lu et al used HPLC to assay on a RP C 18 column with a column temperature of 30 • C, flow rate of 1 mL/min, mobile phase consisting of 0.1% aqueous formic acid, and acetonitrile containing 0.1% formic acid to quantitatively analyze nine triterpenoid saponins simultaneously [26].…”

Section: Hplc With Diode-array Detectionmentioning

confidence: 99%

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Techniques for the analysis of pentacyclic triterpenoids in medicinal plants

Bing

et al. 2017

J of Separation Science

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Triterpenes are a major class of chemical compounds found in natural plants and can be categorized into acyclic triterpenoids, monocyclic triterpenoids, tricyclic triterpenoids, tetracyclic triterpenoids, and pentacyclic triterpenoids. Among them, pentacyclic triterpenoids have gained more extensive attention due to their biological activities, including anti-inflammation, antibacterial, antioxidation, antitumor, anti-HIV, hepatoprotection, and immunological adjuvant properties. In this review, we summarize the extraction and analytical methods for pentacyclic triterpenoids, where more than 56 triterpenes from 49 kinds of plants were involved. The analysis methods include gas chromatography, liquid chromatography, capillary electrophoresis, thinlayer chromatography, supercritical fluid chromatography, NMR spectroscopy, and X-ray spectroscopy. This review provides valuable reference for the determination of pentacyclic triterpenoids in medicinal plants.

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A highly complex stingless bee propolis: Composition and influence of the period of collection

et al. 2022

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Background: Stingless bees or meliponines (family Apidae, subfamily Meliponinae, tribe Meliponini) are eusocial bees from tropical and subtropical regions. Propolis of Scaptotrigona aff. postica (Latreille, 1807) is used in the state of Maranhão (Northeast Brazil) in ointments to treat tumors and wounds. Samples of propolis of S. aff. postica (Apidae, Meliponini) were collected monthly from an apiary located in Barra do Corda (state of Maranhão, Northeast Brazil). Extracts of the 12 samples were obtained with 80% ethanol. Constituents of the samples were characterized by high performance liquid chromatography coupled to photodiode array detector and electrospray ionization tandem mass spectrometry analysis, amounting to 100 substances. Results: Representatives of several classes of secondary metabolites were characterized, including benzoic and cinnamic acids, flavonoids (chalcones, flavone-C-glycosides, flavonol aglycones, and glycosides), alkyl and alkenyl resorcinols, xanthones, diterpenes, cycloartane-type triterpenoids, pentacyclic triterpenoids, pyrrolizidine alkaloids, and hydroxycinnamic acid amides (HCAAs). Considerable qualitative differences in chemical composition among samples were observed, depending on the year period of collection.Principal Coordinate Analysis recognized three distinct year periods (Jan-Mar, April-Sep, Oct-Dec) according to the corresponding chemical profiles. Conclusion:Compared with previous studies, the present work indicates that considerable differences in chemical composition occur also from year to year. Contrary to most propolis types reported so far, which derive exclusively or mostly from a single botanical source, the propolis from Barra do Corda seemingly depends on several resin sources. It is suggested that chalcones and flavonols stem from Mimosa tenuiflora (Mimosoideae); resorcinols, xanthones, and cycloartane-type triterpenoids, from fruits of Mangifera indica (Anacardiaceae); pyrrolizidine alkaloids, possibly from some Crotalaria species (Faboideae); HCAAs probably originate from pollen contaminating the propolis samples.The propolis of S. aff. postica poses challenges and possibilities of study for apicultural researchers, chemists, and pharmacologists.

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Quantitative Determination of 3-O-Acetyl-11-Keto-βBoswellic Acid (AKBA) and Other Boswellic Acids in Boswellia sacra Flueck (syn. B. carteri Birdw) and Boswellia serrata Roxb

Cited by 53 publications

References 29 publications

Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts

Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts

Techniques for the analysis of pentacyclic triterpenoids in medicinal plants

A highly complex stingless bee propolis: Composition and influence of the period of collection

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