Research Review: Neural response to threat in children, adolescents, and adults after child maltreatment – a quantitative meta‐analysis

Hein, Tyler C.; Monk, Christopher S.

doi:10.1111/jcpp.12651

Cited by 182 publications

(180 citation statements)

References 57 publications

(60 reference statements)

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“…In functional MRI studies, we and others have shown that childhood trauma and adversity are associated with increased amygdala reactivity particularly to negative stimuli (e.g. [38–47]) as well as decreased resting functional coupling between the amygdala and vmPFC [48,49]. It is worth noting that such changes have been observed across healthy and psychiatric samples of youth.…”

Section: Impacts Of Child Trauma Exposure On Neurodevelopmentmentioning

confidence: 73%

“…In these studies, amygdala hyperactivation has been reported in only one study of pediatric PTSD [38], with no difference (negative studies) in three others [55–57]. Similar to the case for hippocampal volume, the general lack of average amygdala activation differences is curious given relatively consistent reports of amygdala hyperactivation in both adult PTSD [6–8] and adolescents/adults with a history of childhood trauma [47]. As in the case of hippocampal volume, this could represent a delayed developmental effect, whereby amygdala hyperactivation is not fully apparent until adulthood.…”

Section: Functional Brain Abnormalities During Emotion Processing In mentioning

confidence: 97%

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Trauma, PTSD, and the Developing Brain

Herringa

2017

Curr Psychiatry Rep

183

126

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Purpose of review PTSD in youth is common and debilitating. In contrast to adult PTSD, relatively little is known about the neurobiology of pediatric PTSD, nor how neurodevelopment may be altered. This review summarizes recent neuroimaging studies in pediatric PTSD and discusses implications for future study. Recent findings Pediatric PTSD is characterized by abnormal structure and function in neural circuitry supporting threat processing and emotion regulation. Furthermore, cross-sectional studies suggest that youth with PTSD have abnormal frontolimbic development compared to typically developing youth. Examples include declining hippocampal volume, increasing amygdala reactivity, and declining amygdala-prefrontal coupling with age. Summary Pediatric PTSD is characterized by both overt and developmental abnormalities in frontolimbic circuitry. Notably, abnormal frontolimbic development may contribute to increasing threat reactivity and weaker emotion regulation as youth age. Longitudinal studies of pediatric PTSD are needed to characterize individual outcomes and determine whether current treatments are capable of restoring healthy neurodevelopment.

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Section: Impacts Of Child Trauma Exposure On Neurodevelopmentmentioning

confidence: 73%

Section: Functional Brain Abnormalities During Emotion Processing In mentioning

confidence: 97%

Trauma, PTSD, and the Developing Brain

Herringa

2017

Curr Psychiatry Rep

183

126

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“…Adults with childhood maltreatment exhibited increased STG activity during emotional processing (Hein and Monk, 2016). A meta-analysis associated an inter-connected network of brain regions including the STG during experiences of guilt (Gifuni et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Depression in chronic ketamine users: Sex differences and neural bases

Zhang

Hung³

et al. 2017

Psychiatry Research: Neuroimaging

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Chronic ketamine use leads to cognitive and affective deficits including depression. Here, we examined sex differences and neural bases of depression in chronic ketamine users. Compared to non-drug using healthy controls (HC), ketamine-using females but not males showed increased depression score as assessed by the Center of Epidemiological Studies Depression Scale (CES-D). We evaluated resting state functional connectivity (rsFC) of the subgenual anterior cingulate cortex (sgACC), a prefrontal structure consistently implicated in the pathogenesis of depression. Compared to HC, ketamine users (KU) did not demonstrate significant changes in sgACC connectivities at a corrected threshold. However, in KU, a linear regression against CES-D score showed less sgACC connectivity to the orbitofrontal cortex (OFC) with increasing depression severity. Examined separately, male and female KU showed higher sgACC connectivity to bilateral superior temporal gyrus and dorsomedial prefrontal cortex (dmPFC), respectively, in correlation with depression. The linear correlation of sgACC-OFC and sgACC-dmPFC connectivity with depression was significantly different in slope between KU and HC. These findings highlighted changes in rsFC of the sgACC as associated with depression and sex differences in these changes in chronic ketamine users.

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“…negative facial expressions) (Dannlowski et al, 2012(Dannlowski et al, , 2013Hein & Monk, 2017;Maheu et al, 2010;E. McCrory, De Brito, & Viding, 2011;E.…”

Section: Brain Functioningmentioning

confidence: 99%

The complex neurobiology of resilient functioning after child maltreatment

Ioannidis¹,

Askelund²,

Kievit³

et al. 2016

Preprint

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Childhood Maltreatment (CM) has been associated with significant impairment of social, emotional and behavioural functioning in later life. Nevertheless, some individuals who have experienced CM seem to function better than expected. Here, we provide an integrated understanding of the complex interrelated mechanisms that facilitate such resilient functioning after CM. We show that resilient functioning after CM may be characterized by improved reward, emotion, and stress processing in MPFC and Limbic regions, lower cortisol and inflammatory responses, poly-genetic influences, and supportive environments. As these factors are inextricably intertwined, future resilience studies should investigate multiple levels of biological organization and their temporal dynamics. We further provide a method for such studies to appropriately quantify resilient functioning as functioning across multiple domains conditional on the severity of CM experiences. We hope that our perspective fuels further research in the complex neurobiological mechanisms that facilitate resilient functioning after CM.

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Research Review: Neural response to threat in children, adolescents, and adults after child maltreatment – a quantitative meta‐analysis

Cited by 182 publications

References 57 publications

Trauma, PTSD, and the Developing Brain

Trauma, PTSD, and the Developing Brain

Depression in chronic ketamine users: Sex differences and neural bases

The complex neurobiology of resilient functioning after child maltreatment

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