Edema macular precoz y recurrente en paciente en tratamiento con fingolimod

Cifuentes-Canorea, P.; Nieves-Moreno, M.; Sáenz-Francés, F.; Santos-Bueso, E.

doi:10.1016/j.nrl.2016.08.005

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Macular edema was reported in 21 studies [9, 10, 20-22, 27, 33, 34, 37, 41, 44, 48, 52, 54, 55, 57, 58, 63, 64, 67, 73]; five were classified as cystoid macular edema [20,22,33,44], and one study reported associated retinal hemorrhages [55]. One study described that the symptoms entirely resolved after the discontinuation of medication; when the medication was restarted after two months, the symptomatology reappeared [57]. One patient had macular edema and retinal branch vein occlusion [73], and one patient had macular hemorrhage [24].…”

Section: Teaes Related To Fingolimodmentioning

confidence: 99%

Ocular adverse events from pharmacological treatment in patients with multiple sclerosis—A systematic review of the literature

et al. 2021

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Purpose The aim of this study was to review the scientific evidence and describe the ocular treatment-emergent adverse events (TEAEs) related to pharmacological treatment in patients with multiple sclerosis. Methods A systematic review of literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines in the MEDLINE, LILACS, EMBASE, and COCHRANE databases. Articles were filtered based on title and abstract considering the selection criteria and subsequently filtered by full-text reading. The resulting articles were evaluated using the Joanna Briggs Institute Quality Tools. Study characteristics and results were extracted and presented in structured tables to conduct a narrative synthesis. Results A total of 2852 published articles were extracted using our strategy. After removing duplicates, 2841 articles were screened based on title and abstract, 102 articles were evaluated using quality tools, and 69 articles were filtered by full-text reading. Through this search strategy, 60 articles met all the inclusion criteria and seven articles, through a search update conducted in the same manner, were included. This resulted in 67 articles meeting the inclusion criteria, of which 11 were experimental and 56 were observational. The therapies related to ocular TEAEs were alemtuzumab, amantadine, fingolimod, steroids, CTLA-4 Ig, estriol, interferon β, natalizumab, hyperbaric oxygen, rituximab, siponimod, teriflunomide, and tovaxin. Fingolimod and siponimod were commonly associated with macular edema, interferon β was associated with retinopathy, alemtuzumab was associated with thyroid eye disease, amantadine was associated with corneal edema, and steroids were associated with acute retinal necrosis. Opportunistic infections were also found, and there was one life-threatening case. Conclusions Our search revealed different methodological assessments of the topic. However, longitudinal studies regarding ocular TEAEs related to multiple sclerosis therapy are necessary to provide evidence-based recommendations, especially in understudied regions such as Latin America and Africa. Physicians should monitor ocular symptoms in patients being treated for multiple sclerosis and consider an interdisciplinary approach. Systematic review registration PROSPERO ID CRD42020106886

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Section: Teaes Related To Fingolimodmentioning

confidence: 99%

Ocular adverse events from pharmacological treatment in patients with multiple sclerosis—A systematic review of the literature

et al. 2021

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Fingolimod

2019

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Diagnosis and Management of Fingolimod-Associated Macular Edema

et al. 2022

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ObjectiveTo investigate the clinical features, treatment, and prognosis of fingolimod-associated macular edema (FAME) and to provide a reference for its rational management.MethodsFAME-related case reports were included in a pooled analysis by searching Chinese and English databases from 2010 to November 31, 2021.ResultsThe median age of 41 patients was 50 years (range, 21, 67 years), of whom 32 were women. The median time to onset of FAME was 3 m (range.03, 120), and blurred vision (17 cases) and decreased vision (13 cases) were the most common complaints. A total of 55 eyes were involved in FAME, including the left eye (14 cases), right eye (10 cases), and both eyes (15 cases), of which 46 eyes had best-corrected visual acuity close to normal (20/12-20/60) and 8 eyes had moderate to severe visual impairment (20/80-20/500). Fundus examination in 23 patients showed macular edema (11 cases). Optical coherence tomography (OCT) in 39 patients mainly showed perifoveal cysts (24 cases), ME (23 cases), and foveal thickening (19 cases). Fundus fluorescein angiography (FFA) in 18 patients showed vascular leakage (11 cases). Complete resolution of ME occurred in 50 eyes and recovery of visual acuity occurred in 45 eyes at a median time of 2 m (range 0.25, 24) after discontinuation of fingolimod or administration of topical therapy.ConclusionsMacular edema is a known complication of fingolimod. All patients using fingolimod require regular eye exams, especially those with a history of diabetes and uveitis and those undergoing cataract surgery.

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Edema macular precoz y recurrente en paciente en tratamiento con fingolimod

Cited by 3 publications

References 7 publications

Ocular adverse events from pharmacological treatment in patients with multiple sclerosis—A systematic review of the literature

Ocular adverse events from pharmacological treatment in patients with multiple sclerosis—A systematic review of the literature

Fingolimod

Diagnosis and Management of Fingolimod-Associated Macular Edema

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