Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn

Peng, Ying; Lou, Li‐Li; Liu, Sifan; Zhou, Le; Huang, Xiao‐Xiao; Song, Shao‐Jiang

doi:10.1016/j.bmcl.2016.10.012

Cited by 39 publications

(21 citation statements)

References 21 publications

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“…Differentiation of thymocytes depends on complex signaling cascades, most of which are susceptible to shifts in the redox environment [17,18]. This may partly explain the results obtained in our study, as the antioxidant activity of hawthorn and epicatechin was confirmed in numerous works [3,5,19,20].…”

Section: Discussionsupporting

confidence: 77%

Hawthorn (Crataegus monogyna) Phenolic Extract Modulates Lymphocyte Subsets and Humoral Immune Response in Mice

et al. 2019

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This study investigated the effect of hawthorn (Crataegus monogyna) phenolic extract on lymphocyte subsets in the lymphoid organs in nonimmunized mice and on humoral immune response in sheep red blood cell-immunized mice. Hawthorn phenolic extract (50, 100, 200 mg/kg) was administered orally five or ten times. Sheep red blood cells were injected 24 h after administration of the last extract dose. The lymphocyte subsets were assessed 24 and 72 h after the last dose. Humoral immune response was determined 4 and 7 days after immunization. Five doses of the extract decreased the percentage of CD4−CD8− and CD4+ thymocytes but elevated the percentage of CD4+CD8+ and CD8+ thymic cells. The extract increased the total number, percentage, and absolute count of T and B splenocytes. When administered five times, it lowered the percentage of T lymphocytes, but boosted the population of B lymphocytes of mesenteric lymph nodes (after 24 h). However, a rise in the population of T lymphocytes was observed 72 h after five and ten doses. The extract administered ten times elevated the number of plaque-forming cells and total anti-sheep red blood cell hemagglutinin titer but reduced the 2-ME-resistant antibody titer (day 7). At the same time, five doses of the extract increased antibody titers. Considering its impact on lymphocyte subsets and humoral immune response, hawthorn extract may be used as an immunomodulator.

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Section: Discussionsupporting

confidence: 77%

Hawthorn (Crataegus monogyna) Phenolic Extract Modulates Lymphocyte Subsets and Humoral Immune Response in Mice

et al. 2019

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“…Phytochemical studies of the most widely used C. pinnatifida (Table 2) resulted in separation and purification of 4 new monoterpene glycosides and a new phenolic glycoside in addition to the 10 previously known ones . Furthermore, 15 triterpenoids, including 4 novel acids, in hawthorn berries (Qiao et al, 2015); 2 norditerpenoids with unique carbon skeletons, 4 sesquiterpenoids and 9 nor-sesquiterpenoids from the ethanolic extract of plant leaves (Gao et al, 2017); 8 new phenylpropanoids (crataegusoids A-F) from the fruits (Guo et al, 2018); 8 new lignans (hawthornnins A-H) and 7 known analogues (Huang et al, 2015a); 2 new 8-O-4′-neolignans, huangnin A and B and four known analogs (Huang et al, 2015b); 7 new lignans (crataegusnins A-G) and 5 known compounds from the seeds (Peng et al, 2016) and from crude Crataegus Fructus drug (Kazuma et al, 2016), while 7 known main constituents were separated from the flavonoid fraction of leaves using a combination of high-speed counter-current chromatography (HSCCC) coupled with pre-HPLC (Wen et al, 2017). Crataegusins A and B, new flavanocoumarins, also showed…”

Section: Bioactive Constituents and Antioxidant/antiinflammatory Actimentioning

confidence: 99%

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Venskutonis¹

2018

JFB

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Hawthorn (Crataegus spp.) is one of the most famous plants which has been used as natural medicine and nutraceutical. Its phytochemical composition, bioactive compounds and health benefits have been intensively studied and hawthorn preparations may be recognized as classical natural products for cardiovascular health. Polyphenolic compounds of different hawthorn anatomical parts as well as their extracts have been the focus of a majority of these studies, although various other classes of natural health promoting constituents have also been isolated, identified and characterized. Regardless, numerous published reports have particularly focused on the activity mechanisms which are very important for supporting various health benefits. This review summarizes the most recent studies on hawthorn, mainly published since 2015. Search of different databases indicates that approximately 200 publications, which are relevant to phytochemistry and health benefits of Crataegus spp., have appeared since then, most of them have not been included in the existing reviews.

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“…One study reported that water extracts of C. pinnatifida inhibited NO production and inflammatory gene expression, including TNF-a, COX-2, IL-1b, and IL-6 in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells (Li and Wang, 2011). In addition, ethanol extracts of C. pinnatifida seeds elicit a potent NO and TNF-a inhibitory effect, hence regarded as a promising and reliable source of antioxidants and inhibitors of inflammation (Peng et al, 2016). Clinical evidence showed that when metformin was combined with hawthorn, the level of body mass index (BMI), HbA1c, FPG, 2hPG, TG, and hs-CRP remarkably reduced in patients with prediabetes complicated by nonalcoholic fatty liver disease (Gao et al, 2019).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…In other species such as C. monogyna and C. azarolus, similar types of phenolic compounds were present and categorized into four subclasses: phenolic acids including hydroxycinnamic acids and hydroxybenzoic acid, flavonoids, which are the most abundant components, including flavones and glucosylated flavonols, anthocyanins, such as glycosides of cyanidin, of which cyanidin-3-O-glucoside is the most abundant (Mraihi et al, 2015). Another study identified seven neolignans in the ethanol extract of the C. pinnatifida seeds, which elicited antioxidant and anti-inflammatory effects (Peng et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Roles and Mechanisms of Hawthorn and Its Extracts on Atherosclerosis: A Review

Liu

Xing

et al. 2020

Front. Pharmacol.

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Cardiovascular disease (CVD), especially atherosclerosis, is a leading cause of morbidity and mortality globally; it causes a considerable burden on families and caregivers and results in significant financial costs being incurred. Hawthorn has an extensive history of medical use in many countries. In China, the use of hawthorn for the treatment of CVD dates to 659 AD. In addition, according to the theory of traditional Chinese medicine, it acts on tonifying the spleen to promote digestion and activate blood circulation to dissipate blood stasis. This review revealed that the hawthorn extracts possess serum lipid-lowering, anti-oxidative, and cardiovascular protective properties, thus gaining popularity, especially for its antiatherosclerotic effects. We summarize the four principal mechanisms, including blood lipidlowering, anti-oxidative, anti-inflammatory, and vascular endothelial protection, thus providing a theoretical basis for further utilization of hawthorn.

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Antioxidant and anti-inflammatory neolignans from the seeds of hawthorn

Cited by 39 publications

References 21 publications

Hawthorn (Crataegus monogyna) Phenolic Extract Modulates Lymphocyte Subsets and Humoral Immune Response in Mice

Hawthorn (Crataegus monogyna) Phenolic Extract Modulates Lymphocyte Subsets and Humoral Immune Response in Mice

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Roles and Mechanisms of Hawthorn and Its Extracts on Atherosclerosis: A Review

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