Profile of diabetes in men aged 79–97 years: the Western Australian Health in Men Study

Henze, M.; Alfonso, Helman; Flicker, Leon; George, John D.; Chubb, S. A. Paul; Hankey, Graeme J.; Almeida, Osvaldo P.; Golledge, Jonathan; Norman, Paul; Yeap, Bu B.

doi:10.1111/dme.13274

Cited by 3 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The human correlate is the emergence of sarcopenia and frailty in older age, linked with an increasing incidence and prevalence of diabetes [ 126 ]. In a study of men aged 79–97 years, those with diabetes had poorer physical performance demonstrating the inter-relationship between ageing, deterioration of physical function and diabetes [ 127 ]. Whether ucOC might ameliorate age-related changes in muscle and other tissues to restore physical function and improve glucose homeostasis in humans remains to be seen.…”

Section: Osteocalcin Exercise and Muscle Function—experimental Stmentioning

confidence: 99%

Undercarboxylated Osteocalcin: Experimental and Human Evidence for a Role in Glucose Homeostasis and Muscle Regulation of Insulin Sensitivity

et al. 2018

View full text Add to dashboard Cite

Recent advances have indicated that osteocalcin, and in particular its undercarboxylated form (ucOC), is not only a nutritional biomarker reflective of vitamin K status and an indicator of bone health but also an active hormone that mediates glucose metabolism in experimental studies. This work has been supported by the putative identification of G protein-coupled receptor, class C, group 6, member A (GPRC6A) as a cell surface receptor for ucOC. Of note, ucOC has been associated with diabetes and with cardiovascular risk in epidemiological studies, consistent with a pathophysiological role for ucOC in vivo. Limitations of existing knowledge include uncertainty regarding the underlying mechanisms by which ucOC interacts with GPRC6A to modulate metabolic and cardiovascular outcomes, technical issues with commonly used assays for ucOC in serum, and a paucity of clinical trials to prove causation and illuminate the scope for novel health interventions. A key emerging area of research is the role of ucOC in relation to expression of GPRC6A in muscle, and whether exercise interventions may modulate metabolic outcomes favorably in part via ucOC. Further research is warranted to clarify potential direct and indirect roles for ucOC in human health and cardiometabolic diseases.

show abstract

Section: Osteocalcin Exercise and Muscle Function—experimental Stmentioning

confidence: 99%

Undercarboxylated Osteocalcin: Experimental and Human Evidence for a Role in Glucose Homeostasis and Muscle Regulation of Insulin Sensitivity

et al. 2018

View full text Add to dashboard Cite

show abstract

“…44 Henze ve ark., yaş aralığı 79-97 yıl arasında olan diyabetli hastalarla yaptıkları çalışmanın sonunda, diyabetin yaşam kalitesi, kalp hastalıkları ve düşmelerle ilişkili olduğunu rapor etmişlerdir. 45 İyi glisemik kontrol seviyesi, sağlıklı yaşam tarzı davranışlarının teşvik edilmesi, fiziksel fonksiyonun geliştirilmesi bakımından hastaların cesaretlendirilmesinin önemli olduğu vurgulanmıştır.…”

Section: Bulgularunclassified

The Effect of Diabetes on Life Quality of Individuals with Type 2 Diabetes

Yümin¹,

Bakar²,

Şimşek³

2017

Turkiye Klinikleri J Sports Sci

View full text Add to dashboard Cite

Ö ÖZ ZE ET T A Am ma aç ç: : Tip 2 diabetes mellitus (DM) tanısı olan bireylerde diyabetin yaşam kalitesi üze-rine olan etkisini incelemekti. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya dahil edilen bireyler, hafif-orta periferik nöropatisi olan DM'li hastalar (Grup 1:100), nöropatisi olmayan DM'li hastalar (Grup 2:100) ve sağlıklı bireyler (Grup 3:100) olmak üzere 3 gruba ayrıldı. Bireylerin sosyo-demografik bilgileri, klinik özellikleri kaydedildikten sonra sağlıkla ilgili yaşam kalitesi için Kısa Form-36 (SF-36) ölçeği kullanıldı. B Bu ul lg gu ul la ar r: : Bireylerin yaş ve beden kütle indeks değerleri sırasıyla, Grup 1 için 61,54±8,59 yıl, 30,34±4,57kg/m 2 , Grup 2 için 59,82±8,19 yıl, 29,91± 4,71kg/m 2 Grup 3 için 59,72±10,04 yıl, 28,91±4,10 kg/m 2 idi.Yaş ortalamaları ve beden kitle indeksi değerleri bakımından gruplar arasında, fark bulunmadı (p>0,05). Sistemik hastalık varlığı, ayakta yanma hissi ve kolesterol değerlerinde DM'li hastalarda (Grup 1 ve 2) istatistiksel bir fark bulunmadı (p>0,05), fakat, sağlıklı kontrol grubu ile DM'li hastalar arasında fark bulundu (p<0,05). Açlık-tokluk glukoz, Hemoglobin A1c, diyabet yılı ve oral antidiyabetik ilaç kullanım süresi Grup 2 ile karşılaştırıldığında, Grup 1'de daha yüksek idi (p<0,05). İnsülin kullanım süreleri bakımın-dan diyabetli gruplar arasında bir fark gözlenmedi (p>0,05). Yaşam kalitesi ölçeği SF-36'nın tüm alt parametreleri bakımından gruplar arasında fark olduğu saptandı (p<0,05). S So on nu uç ç: : DM'li hastalarda yaşam kalitesinin önemli derecede azaldığı görüldü. Diyabetin sağlıkla ilgili yarattığı olumsuz etkilerini tespit etmeye yönelik çalışmalar yaşam kalitesinin artırılmasına katkıda bulunacaktır.A An na ah ht ta ar r K Ke el li im me el le er r: : Diabetes mellitus; yaşam kalitesi A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The purpose of this study was to examine the effect of diabetes on life quality of individuals with Type 2 Diabetes. M Ma at te er rı ıa al l a an nd d M Me et th ho od ds s: : The participants of the study were divided into 3 groups; diabetic individuals with light-mild peripheral neuropathy (Group 1:100); diabetic individuals with no neuropathy (Group 2:100); and healthy individuals (Group 3:100). After socio-demographic data and clinical characteristics were recorded, short-form-36 (SF-36) questionnaire was applied for the life quality. R Re es su ul lt ts s: : Ages and body mass index values of the individuals were as follows for the three groups, respectively: 61.54±8.59years, 30.34±4.57 kg/m 2 ; 59.82±8.19 years, 29,91±4.71 kg/m 2 ; and 59.72±10.04 years, 28.91±4.10 kg/m 2 . No differences were detected among the groups in terms of average age and body mass index values (p>0.05). Although no differences were detected in the existence of systemic diseases, burning on feet and cholesterol values did not vary between Group 1 and 2 (p>0.05); they were higher than those of the control group (p<0.05). Fasting glucose-postprandial glucose values, hemoglobin A1c, duration of diabetes as...

show abstract

The diagnosis and management of diabetes in Australia: Does the “Rule of Halves” apply?

Sainsbury

Shi

Flack

et al. 2020

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

Profile of diabetes in men aged 79–97 years: the Western Australian Health in Men Study

Cited by 3 publications

References 31 publications

Undercarboxylated Osteocalcin: Experimental and Human Evidence for a Role in Glucose Homeostasis and Muscle Regulation of Insulin Sensitivity

Undercarboxylated Osteocalcin: Experimental and Human Evidence for a Role in Glucose Homeostasis and Muscle Regulation of Insulin Sensitivity

The Effect of Diabetes on Life Quality of Individuals with Type 2 Diabetes

The diagnosis and management of diabetes in Australia: Does the “Rule of Halves” apply?

Contact Info

Product

Resources

About