Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children

Brnić, Marica; Hurrell, Richard F.; Songré-Ouattara, Laurencia T.; Diawara, Bréhima; Kalmogho-Zan, Angèle; Tapsoba, C.; Zeder, Christophe; Wegmüller, Rita

doi:10.1038/ejcn.2016.199

Cited by 16 publications

(21 citation statements)

References 44 publications

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“…Sources of zinc include beans, red meat (beef, veal, lamb, and mutton) and biofortified eggs and wheat [ 12 – 15 ]. Phytate in beans, unrefined grains, and nuts is the main inhibitor of dietary zinc absorption [ 16 – 18 ]. However, the chelation of phytate and zinc can be disrupted by improving food processing methods (soaking, heating, and fermentation) to improve the bioavailability of zinc [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Protective role of zinc in the pathogenesis of respiratory diseases

et al. 2022

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Respiratory diseases remain a major cause of morbidity and mortality worldwide. An imbalance of zinc, an essential trace element, is associated with a variety of lung diseases. We reviewed and summarized recent research (human subjects, animal studies, in vitro studies) on zinc in respiratory diseases to explore the protective mechanism of zinc from the perspective of regulation of oxidative stress, inflammation, lipid metabolism, and apoptosis. In the lungs, zinc has anti-inflammatory, antioxidant, and antiviral effects; can inhibit cancer cell migration; can regulate lipid metabolism and immune cells; and exerts other protective effects. Our comprehensive evaluation highlights the clinical and experimental effects of zinc in the pathogenesis of respiratory diseases. Our analysis also provides insight into the clinical application of zinc-targeted therapy for respiratory diseases.

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Section: Introductionmentioning

confidence: 99%

Protective role of zinc in the pathogenesis of respiratory diseases

et al. 2022

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“…However, the method for adults requires the calculation of both total zinc and phytate intakes, and phytate values are not included in all food composition tables, which limits the feasibility of applying this algorithm. For children, the observation that dietary phytate did not predict zinc absorption [24] is inconsistent with other evidence indicating that phytate reduction increased zinc absorption [52,53]; further efforts to understand zinc absorption among young children may improve estimates of absorbable zinc in dietary studies.…”

Section: Discussionmentioning

confidence: 71%

Applying Zinc Nutrient Reference Values as Proposed by Different Authorities Results in Large Differences in the Estimated Prevalence of Inadequate Zinc Intake by Young Children and Women and in Cameroon

et al. 2022

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Nutrient reference values (NRVs) for zinc set by several expert groups differ widely and may affect the predicted prevalence of inadequate zinc intake. We examined this possibility using NRVs published by four different authorities and nationally representative dietary intake data collected among children aged 12–59 months and women in Cameroon. Usual zinc intake was estimated from 24 h recall data using the National Cancer Institute method. Prevalences of total zinc intake below the dietary requirement and of “absorbable zinc intake” below the physiological requirement were estimated using NRVs published by the World Health Organization (WHO), US Institute of Medicine (IOM), International Zinc Nutrition Consultative Group (IZiNCG), and European Food Safety Authority (EFSA). The prevalence of inadequate zinc intake ranged from 10% (IZiNCG—physiological requirement, 95% CI 7–13%) to 81% (EFSA—physiological requirement, 95% CI 78–84%) among children and 9% (WHO—physiological requirement, 95% CI 8–11.0%) to 94% (IOM—physiological requirement, 95% CI 92–95%) among women These differences in the prevalence of inadequate intake translated into sizeable differences in the predicted benefit and cost-effectiveness of zinc fortification programs. Depending on the NRVs applied, assessments differ regarding the need for and design of zinc fortification programs. Efforts are needed to harmonize NRVs for zinc.

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“…As crianças que consomem a multimistura poderão apresentar efeitos deletérios sobre sua saúde, tais como baixa concentração de zinco capilar, menor absorção de zinco e influência negativa sobre seu crescimento. Efeitos nocivos de dietas com elevado teor de ácido fítico sobre animais e humanos são mostrados na literatura (BRNIĆ et al, 2017;HIGASHIJIMA et al, 2020). A ação quelante do fitato pode ocorrer, se o mesmo estiver, especialmente, na forma hexafosfórica, quando exerce efeito complexante sobre os cátions (Zn, Ca, Fe) da dieta em condições de pH alcalino no meio intraluminal do intestino (DOMENE et al, 2008).…”

Section: áCido Fíticounclassified

Avaliação nutricional e biodisponibilidade de minerais em multimisturas / Nutritional evaluation and bioavailability of minerals in multimixtura

Sampaio¹,

Oliveira²,

Sampaio³

et al. 2022

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Uma organização de ação social brasileira, implementou um programa de alimentação alternativa baseado no uso de uma multimistura composta de farelo de trigo e arroz, fubá, casca de ovo de galinha, sementes (gergelim, abóbora-moranga, girassol e amendoim) e pó de folhas verdes (mandioca), utilizadas como suplemento alimentar, principalmente na recuperação de crianças desnutridas. No entanto, tem sido questionada a sua aplicação com relação ao valor nutricional, em virtude da presença de prováveis fatores antinutricionais e/ou tóxicos. Portanto, este estudo teve como objetivo avaliar a multimistura, quanto a esses fatores e à biodisponibilidade dos minerais. As amostras foram obtidas na Pastoral da Criança de Fortaleza (Brasil). Os resultados das análises mostraram a presença de inibidores de tripsina e α-amilase, taninos, metais pesados e ácido fítico, baixas biodisponibilidades de zinco e ferro devidas à presença de fitatos, sem comprometimento da biodisponibilidade do cálcio. Esses fatores e a baixa biodisponibilidade dos minerais podem comprometer o valor nutricional da multimistura como suplemento alimentar para humanos e principalmente para crianças. Entretanto, o cálcio proveniente do pó das cascas de ovo de galinha mostrou-se ser biodisponível podendo ser consumido como suplemento mineral.

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Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children

Abstract: Adding phytase immediately prior to consumption of a zinc-fortified cereal-based complementary food can improve zinc absorption in young children.

Cited by 16 publications

References 44 publications

Protective role of zinc in the pathogenesis of respiratory diseases

Protective role of zinc in the pathogenesis of respiratory diseases

Applying Zinc Nutrient Reference Values as Proposed by Different Authorities Results in Large Differences in the Estimated Prevalence of Inadequate Zinc Intake by Young Children and Women and in Cameroon

Avaliação nutricional e biodisponibilidade de minerais em multimisturas / Nutritional evaluation and bioavailability of minerals in multimixtura

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