An Incidental Solitary Plasmacytoma of Bone Mimicking Neuroendocrine Tumor Metastasis on 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography

D, Has Şimşek; Kuyumcu, Serkan; Bılgıç, Bilge; Eg, Işık; Türkmen, Cüneyt; Adalet, İşık

doi:10.4274/mirt.93064

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…[ 55 ] Previously, it was reported that a solitary plasmacytoma in the body of the third lumbar vertebra had mild Ga-68 DOTATATE uptake. [ 56 ] These findings emphasize that other osseous lesions can express SSTRs and should not be mistaken for tumor metastasis when evaluating positive foci of osseous uptake.…”

Section: Discussionmentioning

confidence: 89%

Ga-68 DOTATATE PET/CT in the evaluation of paragangliomas and other indeterminate lesions in the head and neck

et al. 2022

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Background and Purpose: Paragangliomas (PGLs) are rare neuroendocrine tumors with imaging features that can overlap with other entities. This study hypothesizes that given overexpression of somatostatin receptor (SSTR) 2, PGLs can be differentiated on Ga-68 DOTATATE positron emission tomography/computed tomography (PET/CT) from other benign or malignant lesions. Materials and Methods: Ninety-six patients with known tumors of the head and neck who underwent Ga-68 DOTATATE PET/CT from May 2017 to December 2021 were retrospectively reviewed from a single institution. Of these, 43 patients had histopathological confirmation and 66 positive lesions were discovered on PET/CT. For each lesion, the SUV max, the SUV lesion to liver ratio, and the SUV lesion to spleen ratio were analyzed. Results: PGLs ( n = 37) showed the most intense uptake, and the mean of SUVmax was 69.3 (range 3.7–225.9). Metastatic PGL and metastasis from other neuroendocrine tumors ( n = 13) demonstrated intermediate uptake, the mean of SUVmax was 15.16 (range 2.3–40.3). Meningiomas ( n = 3) had intermediate uptake, and the mean of SUVmax was 12.37 (range 2.5–19.4). One patient with esthesioneuroblastoma had 5 lesions in the head and neck, and the mean of SUVmax was 18.9 (range 6.9–49.4). Schwannomas ( n = 4) had very low uptake, and the mean of SUVmax was 1.75 (range 1.1–2.2). Other rare cases with low uptake included 1 each of osteosarcoma, acinic cell carcinoma, ectopic thyroid tissue, and plasmacytoma, and the mean of SUVmax was 4.75 (range 2.3–6.1). Conclusions: Ga-68 DOTATATE PET/CT can be a useful adjunct in differentiating tumors in the head and neck. PGLs demonstrate the highest uptake. Meningioma, esthesioneuroblastoma, and neuroendocrine tumor metastasis have intermediate uptake. Schwannomas and other rare tumors exhibit low uptake.

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Section: Discussionmentioning

confidence: 89%

Ga-68 DOTATATE PET/CT in the evaluation of paragangliomas and other indeterminate lesions in the head and neck

et al. 2022

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“…In the case study by Has Simsek et al, the lesion of the spine was proven to be a malignant solitary bone plasmacytoma on further diagnostics [ 24 ]. In the single center cohort studies by Gauthe et al (2018), a total of 28 patients with incidental spine SSTR PET findings were consistent with vertebral hemangiomas on diagnostic imaging [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Prevalence and significance of incidental findings on 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT: a systematic review of the literature

2022

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Aim We aimed to evaluate the prevalence of incidental 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT (SSTR PET/CT) findings, their clinical significance in the need for follow-up, and their risk of malignancy. Materials and methods Studies reporting incidental SSTR PET/CT findings were systematically searched in PubMed, Cochrane, Embase and Web of Science literature published prior to 1st of May 2020. Studies were filtered by two independent readers for eligibility based on title and abstract, and subsequently on full text. The main exclusion criteria were: 1) pathological findings that matched scan indication, 2) known organ specific disease and/or incidental findings confirmed on other scan modality prior to SSTR PET/CT, 3) lack of diagnosis and/or follow up, and 4) results published in proceedings or conference abstracts. Results Twenty-one studies, comprising a total of 2906 subjects, were eligible for the analysis. Studies included were retrospective cohort studies on incidental SSTR PET/CT findings in a specific organ (n = 2888, 7/21) or case reports (n = 18, 14/21). A total of 133 subjects had incidental SSTR PET/CT findings. Incidental findings were predominantly seen in the thyroid gland (n = 65), spine (n = 30), brain (n = 26) and breast (n = 6). Seventeen of 133 (13%) incidental findings were malignant on final diagnosis. Incidental breast findings were associated with the highest risk of malignancy (67%). In the thyroid, incidental SSTR uptake was caused by malignancy in 8%, all presenting as focal uptake. The lowest risk was seen in the spine with a malignancy rate of 3% in patients with incidental SSTR uptake and benign cases were interpreted as vertebral hemangiomas on CT. Incidental SSTR PET/CT findings in other locations were of malignant etiology in two out of six cases (33%) and should be evaluated individually. Conclusion The most incidental SSTR PET/CT findings were found in the thyroid gland, spine, and brain. The risk of malignancy was greatest in incidental SSTR PET/CT findings in the breast, cranially, and thyroid gland. The results of the present study can prove useful in the interpretation of atypical findings on SSTR PET/CT and in the counseling of clinicians.

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Somatostatin receptor-positive breast lesions on 68Ga-DOTATATE PET/CT

et al. 2021

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An Incidental Solitary Plasmacytoma of Bone Mimicking Neuroendocrine Tumor Metastasis on 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography

Cited by 8 publications

References 16 publications

Ga-68 DOTATATE PET/CT in the evaluation of paragangliomas and other indeterminate lesions in the head and neck

Ga-68 DOTATATE PET/CT in the evaluation of paragangliomas and other indeterminate lesions in the head and neck

Prevalence and significance of incidental findings on 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT: a systematic review of the literature

Somatostatin receptor-positive breast lesions on 68Ga-DOTATATE PET/CT

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