Use of Scaffolding Tissue Biografts To Bolster Vesicourethral Anastomosis During Salvage Robot-assisted Prostatectomy Reduces Leak Rates and Catheter Times

Application of Dried Human Amnion Graft to Improve Post-Prostatectomy Incontinence and Potency: A Randomized Exploration Study Protocol

“…As a result of its extracellular matrix composition, HAM is assumed to be preferable for tissue outgrowth. Amnion provided faster healing of vesicourethral anastomosis and reduced indwelling catheter time in a small retrospective study for 15 patients during salvage RP (IDEAL stage 1) [26]. The time of catheter removal was an independent predictor of urinary continence recovery after RP in a prospective trial with 197 patients (IDEAL stage 2a) [41].…”

“…Subsequently, the vesicourethral anastomosis (VUA) is prepared and then wrapped with HAM ( Fig. 1) [26].…”

Bridging the gap: use of scaffolding tissue bio-grafts to bolster vesicourethral anastomosis during salvage robot-assisted prostatectomy reduced leak rates and catheter times

“…Of note, vesicourethral anastomosis (VUA) leak can occur in up to one third of cases (1). Contributing factors are often attributed to prior therapy and include increased tissue friability and postoperative necrosis, and despite efforts to ensure a high quality of surgical anastomosis, poor surrounding tissue quality can result in anastomosis disruption (2). The deleterious effects of a VUA leak are numerous; urethral stricture formation, bladder neck contracture, urinary peritonitis and paralytic ileus.…”

“…Ogaya Pinies et al evaluate a novel use of Matristem (ACell, Columbia, MD, USA), a connective tissue scaffold reinforcement of the VUA and distal bladder in preventing VUA disruption during sRARP (2). This acellular, reabsorbable material is derived from porcine urinary bladder (3).…”

Complications after salvage radical prostatectomy: vesicourethral anastomosis leaks and possible prevention

“…In an article for the Surgery in Motion section of European Urology, Ogaya-Pinies and colleagues described feasibility, safety and functional outcomes for the use of a scaffolding tissue graft to prevent VUA rupture after salvage RALP ( 15 ). In 15 sRALP patients, a single surgeon incorporated porcine urinary bladder extracellular matrix (UB-ECM) into the posterior part of the VUA base and distal bladder neck.…”