Circulating microRNAs as novel biomarkers for dilated cardiomyopathy

Wang, Hua; Chen, Feng; Tong, Jiabin; Li, Yingying; Cai, Jianping; Wang, Yan; Peng, Li; Hao, Yichun; Tian, Weimeng; You, Li; Chong, Jia Wen; Yang, Jiao

doi:10.5603/cj.a2016.0097

Cited by 23 publications

(23 citation statements)

References 29 publications

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“…miR-3135b is a biomarker of coronary artery calcification, heart failure, and non-ST segment elevation acute coronary syndromes, which is closely related to a poor cardiovascular prognosis [ 30 , 31 ]. Thus, elevation of miR-3135b in the LNIV without crescents group may suggest that those patients are more likely to develop systemic lupus erythematosus-related cardiac damage.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA expression profile of urinary exosomes in Type IV lupus nephritis complicated by cellular crescent

Tang

et al. 2018

J of Biol Res-Thessaloniki

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BackgroundType IV lupus nephritis (LNIV) is a severe disease characterized by diffuse proliferative lesions, and its prognosis is worse with cellular crescent (LNIV-CC) involvement. Urinary exosomes have been shown to reflect the degree of kidney injury. This study was aimed to identify non-invasive diagnostic markers for LNIV-CC. We analysed the expression profile of microRNAs (miRNAs) isolated from urinary exosomes in patients with LNIV-CC and LNIV, and healthy individuals using high-throughput sequencing.ResultsA total of 66 differentially expressed miRNAs were identified, which were significantly enriched in 15 signalling pathways. Bioinformatic analysis revealed a co-expression network of miRNAs, predicted transcription factors and target mRNAs. Expression of three miRNAs including miR-3135b, miR-654-5p, and miR-146a-5p were further analysed and validated by reverse transcription-quantitative polymerase chain reaction. ROC analysis suggested these as candidate biomarkers for LNIV-CC.ConclusionsLNIV-CC has a unique miRNA expression profile of urinary exosome and complex regulatory network. miR-3135b, miR-654-5p and miR-146a-5p in urinary exosomes could be used as novel non-invasive diagnostic markers for LNIV-CC.

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Section: Discussionmentioning

confidence: 99%

MicroRNA expression profile of urinary exosomes in Type IV lupus nephritis complicated by cellular crescent

Tang

et al. 2018

J of Biol Res-Thessaloniki

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“…Plasma miR-3135b and miR-5571-5p also provided optimal discriminative potential to distinguish between healthy controls and DCM patients (AUC = 1.00 and 0.91, respectively). 64 In the field of prognostication, plasma levels of miR-185 have been proposed as a biomarker in newly diagnosed patients with DCM. 65 Patients with high miR-185 levels showed improvements in LV ejection fraction (LVEF) and LV end diastolic diameter, and a significant decline in both cardiovascular mortality and total admissions for HF rehospitalizations during a 1-year follow-up period.…”

Section: Micrornas and Dilated Cardiomyopathymentioning

confidence: 99%

Emerging role of microRNAs in dilated cardiomyopathy: evidence regarding etiology

Calderón‐Domínguez

Belmonte

Quezada-Feijoó

et al. 2020

Translational Research

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Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by ventricular dilation and systolic dysfunction in the absence of abnormal loading conditions or coronary artery disease. This cardiac disorder is a major health problem due to its high prevalence, morbidity, and mortality. DCM is a complex disease with a common phenotype but heterogeneous pathological mechanisms. Early etiological diagnosis and prognosis stratification is crucial for the clinical management of the patient. Advances in imaging technology and genetic tests have provided useful tools for clinical practice. Nevertheless, the assessment of the disease remains challenging. Novel noninvasive indicators are still needed to assist in decisionmaking. microRNAs (miRNAs), a group of small noncoding RNAs, have been identified as key mediators of cell biology. They are found in a stable form in body fluids and their concentration is altered in response to stress. Previous research has suggested that the miRNA signature constitutes a novel source of noninvasive biomarkers for a wide array of cardiovascular diseases. Specifically, several studies have reported the potential role of miRNAs as clinical indicators among the etiologies of DCM. However, this field has not been reviewed in detail. Here, we summarize the evidence of intracellular and circulating miRNAs in DCM and their usefulness in the development of novel diagnostic, prognostic and therapeutic approaches, with a focus on DCM etiology. Although the findings are still

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“…Aberrant miRNA expression has been investigated, not only in oncologic conditions, in which they regulate tumour suppressor genes and oncogenes [10,11], but also in different cardiovascular diseases [12][13][14]. As regards primary cardiomyopathies, the role of circulating miRNAs has been investigated for Hypertrophic Cardiomyopathy (HCM) [15][16][17][18], Dilated Cardiomyopathy (DCM) [19][20][21], and AC [22][23][24][25], showing remarkable stability under extreme conditions and suggesting their implication not only in cell-cell communication (as selectively secreted molecules), but also as a response to tissue-damage (as passive released molecules) in the onset and development of the disease [12]. Thus, the potential of circulating miRNAs as disease biomarkers is promising, given their function and localization inside and outside the cells in microvesicles, exosomes, apoptotic bodies, or associated with RNA-binding proteins.…”

Section: Introductionmentioning

confidence: 99%

A microRNA Expression Profile as Non-Invasive Biomarker in a Large Arrhythmogenic Cardiomyopathy Cohort

Marinas

Celeghin

Cason

et al. 2020

IJMS

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Arrhythmogenic Cardiomyopathy (AC) is a clinically and genetically heterogeneous myocardial disease. Half of AC patients harbour private desmosomal gene variants. Although microRNAs (miRNAs) have emerged as key regulator molecules in cardiovascular diseases and their involvement, correlated to phenotypic variability or to non-invasive biomarkers, has been advanced also in AC, no data are available in larger disease cohorts. Here, we propose the largest AC cohort unbiased by technical and biological factors. MiRNA profiling on nine right ventricular tissue, nine blood samples of AC patients, and four controls highlighted 10 differentially expressed miRNAs in common. Six of these were validated in a 90-AC patient cohort independent from genetic status: miR-122-5p, miR-133a-3p, miR-133b, miR-142-3p, miR-182-5p, and miR-183-5p. This six-miRNA set showed high discriminatory diagnostic power in AC patients when compared to controls (AUC-0.995), non-affected family members of AC probands carrying a desmosomal pathogenic variant (AUC-0.825), and other cardiomyopathy groups (Hypertrophic Cardiomyopathy: AUC-0.804, Dilated Cardiomyopathy: AUC-0.917, Brugada Syndrome: AUC-0.981, myocarditis: AUC-0.978). AC-related signalling pathways were targeted by this set of miRNAs. A unique set of six-miRNAs was found both in heart-tissue and blood samples of AC probands, supporting its involvement in disease pathogenesis and its possible role as a non-invasive AC diagnostic biomarker.

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Circulating microRNAs as novel biomarkers for dilated cardiomyopathy

Abstract: (miR-3135b, miR-3908 and miR-5571-5p) have potential as diagnostic biomarkers for DCM. Additionally, miR-5571-5p correlated with NYHA classification. (Cardiol J 2017; 24, 1: 65-73)

Cited by 23 publications

References 29 publications

MicroRNA expression profile of urinary exosomes in Type IV lupus nephritis complicated by cellular crescent

MicroRNA expression profile of urinary exosomes in Type IV lupus nephritis complicated by cellular crescent

Emerging role of microRNAs in dilated cardiomyopathy: evidence regarding etiology

A microRNA Expression Profile as Non-Invasive Biomarker in a Large Arrhythmogenic Cardiomyopathy Cohort

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