Prevalence and Predictors of Metabolic Syndrome After Liver Transplantation

Perez, L. Vida; Álvarez, Jorge Lima; González, Antonio; Delgado, Javier Briceño; Rodero, G. Costán; Rivas, E. Fraga; Baena, Pilar Barrera; García, Manuel de la Mata

doi:10.1016/j.transproceed.2016.08.029

Cited by 13 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sonny et al followed LT recipients for a median of 3‐4 years and found that left ventricular hypertrophy and diastolic dysfunction continues to worsens after LT, 68 which in turn increases their risk of diastolic heart failure. Also, it is well known that metabolic syndrome is common among patients after LT, increasing their risk for cardiovascular complications and coronary artery disease 69 . This is consistent with data showing that ischemic etiology plays an important role in late onset AHF after LT 68 …”

Section: Predictors Of Heart Failure After Liver Transplantationsupporting

confidence: 75%

Acute heart failure after liver transplantation: A narrative review

Sharma

Sonny

Dalia

et al. 2020

Clinical Transplantation

View full text Add to dashboard Cite

Acute heart failure (AHF) is present in a substantial proportion of patients after liver transplantation (LT), and is associated with significant morbidity and mortality. 1-4 The pretransplant hemodynamic changes (decreased systemic vascular resistance (SVR), poor ventricular response to stress and increased cardiac output) that occur in patients with end-stage liver disease (ESLD) coupled with the effects of pro-inflammatory cytokines released during reperfusion of the liver during transplantation have been implicated in both systolic and diastolic dysfunction, contributing to AHF. 5 Both ischemic and non-ischemic causes have been implicated. While ischemic heart disease, has well defined risk factors, and may be identified preoperatively, non-ischemic AHF, is a poorly understood entity and can occur in the absence of obvious risk factors. Standard preoperative workup including electrocardiogram (EKG), echocardiography at rest or on stress, or biomarkers has limitations in predicting this risk. Cirrhotic cardiomyopathy, iron overload cardiomyopathy, and stress-induced cardiomyopathy are some of the commonly implicated entities. Distinguishing one etiology from the other is difficult and multiple etiologies may coexist in the same patient. While early recognition of risk factors and diagnosis is difficult, once diagnosed, there are no clear-cut rules for candidacy of transplant in these patients and no guidelines exist to help optimize these patients prior to transplant. These patients are at a high-risk of cardiovascular collapse either during the intraoperative period or in the immediate postoperative period and approaches to mitigate these risks as

show abstract

Section: Predictors Of Heart Failure After Liver Transplantationsupporting

confidence: 75%

Acute heart failure after liver transplantation: A narrative review

Sharma

Sonny

Dalia

et al. 2020

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…The presence of cardiovascular risk factors before OLT has been shown to be predictive of HF or cardiovascular events months to years after OLT . Additionally, more than half of the patients undergoing OLT develop metabolic syndrome within 3 years of OLT . Early identification of this patient population may allow aggressive risk factor modification.…”

Section: Discussionmentioning

confidence: 99%

Systolic heart failure after liver transplantation: Incidence, predictors, and outcome

Sonny

Govindarajan

Jaber

et al. 2018

Clinical Transplantation

View full text Add to dashboard Cite

Although most patients presenting for liver transplantation have normal left ventricular function, some develop left ventricular failure after transplantation. The primary objective of our study was to determine the predictors of systolic heart failure (HF) occurring immediately after liver transplantation. Its etiology, prospects of recovery, and factors associated with nonrecovery were also studied. Liver transplantations performed at our institution from January 2006 to February 2015 were evaluated using prospectively collected institutional registries. Patients with echocardiographically documented decline in ejection fraction to <45% within 6 months after liver transplantation were identified. Four controls were chosen per case: matched for age, gender, transplant year, and model for end-stage liver disease score. Conditional multivariable logistic regression was used for primary analysis and nonparametric tests for comparison between groups. In a cohort of 1284 adult patients, 45 cases and 180 controls were identified. Diastolic dysfunction (DD) was an independent predictor (OR 5.26, 95% CI 1.03-28.57, P = .04) of systolic HF in multivariable analysis. Stress-induced cardiomyopathy was the most common etiology. Left ventricular function recovered in 21 patients. Pretransplant DD decreased the chances of recovery (P = .05). In conclusion, patients with pretransplant DD need close post-transplant follow-up for timely identification of HF.

show abstract

“…Of the 15 included cohort studies, majority were retrospective (n = 14) and there was one prospective study. The studies were conducted in various countries including 4 in Italy, [30][31][32][33] 3 in Spain, [34][35][36] and one in the United States, [37] Australia, [38] Belgium, [39] Singapore, [40] China, [41] Israel, [42] Germany, [5] and India, [43] respectively. A total of 2683 LT recipients were included in this study, with 740 patients developing de novo PTMS.…”

Section: Summary Of Included Articlesmentioning

confidence: 99%

De novo metabolic syndrome after liver transplantation: a meta-analysis on cumulative incidence, risk factors, and outcomes

Lim

Tan

Xiao

et al. 2023

Liver Transplantation

View full text Add to dashboard Cite

Post-transplant metabolic syndrome (PTMS) has been associated with increased cardiovascular risk which significantly impacts the morbidity and mortality rates of liver transplant (LT) recipients. This study sought to conduct a meta-analysis and systematic review on the cumulative incidence, risk factors, and cardiovascular outcomes associated with de novo PTMS.Medline and Embase were searched for articles describing the incidence, risk factors, and cardiovascular outcomes of de novo PTMS. Meta-analysis of proportions was conducted to calculate incidence. Conventional pairwise analysis using random effects model was used to tabulate OR and hazard ratio for risk factors and cardiovascular outcomes, respectively. Fifteen studies involving

show abstract

Prevalence and Predictors of Metabolic Syndrome After Liver Transplantation

Cited by 13 publications

References 8 publications

Acute heart failure after liver transplantation: A narrative review

Acute heart failure after liver transplantation: A narrative review

Systolic heart failure after liver transplantation: Incidence, predictors, and outcome

De novo metabolic syndrome after liver transplantation: a meta-analysis on cumulative incidence, risk factors, and outcomes

Contact Info

Product

Resources

About