“…It is a marker of sensory neuron population of nociceptive neurons as well (Yoshimura et al, 1998; Suzuki et al, 2003) CGRP is expressed in small‐diameter unmyelinated nociceptive neurons (Marmigère and Ernfors, 2007) activated by thermal, chemical and mechanical stimuli with sensitivity to capsaicin. CGRP was reported in small diametar fibers in the SC of lower vertebrates (Carlton et al, 1987; Torres‐Da‐Silva et al, 2016) and humans (Harmann et al, 1988), in motoneurons of the adult rats, in the fibres and terminals of dorsal horn and epidermis of the skin (Marti et al, 1987) as well as in small neurons of trigeminal and vagal ganglia (Poyner, 1992). VR1 is a non‐selective cation channel from the transient receptor potential (TRP) family (Anand et al, 2008), activated by capsaicin and by noxious heat and protons (Hou et al, 2002; Huang et al, 2002; Vulcu et al, 2003).…”