Cutaneous carcinosarcoma: a series of six cases and a review of the literature

Abstract

We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series.

Trichoblastic carcinosarcoma: A case report and literature review

“…Half of the patients saw rapid growth in a year or less and three of these patients reported a precursor lesion that had been stable for 10 years or more. The most common location was the head (6 of 8 cases), with other sites including the shoulder and back …”

“…The sarcomatous component is positive for vimentin, CD10, and p53. Both components are negative for epithelial membrane antigen, CD34, Mart‐1, SOX10, actin, desmin, and CK20 . Thus far, the molecular alterations of the tumor are unknown, most likely due to the small number of cases available for testing.…”

“…Clinically, metaplastic carcinoma of the skin occurs in elderly males and presents non‐specifically, with ulceration and a rapid growth phase. It is often aggressive, with higher metastatic rates in tumors displaying squamous differentiation …”

“…The most common location was the head (6 of 8 cases), with other sites including the shoulder and back. [2][3][4][5][6][7][8] Histopathologically, trichoblastic carcinosarcoma is dermal based with no epidermal connection reported in any case. It can be variably surrounded by benign adnexal structures including immature hair follicles and papillae.…”

“…Both components display nuclear pleomorphism, cytologic atypia, and increased mitotic activity in tumors displaying squamous differentiation. 7,[9][10][11] Molecular data are important for future studies to help establish the histogenesis of trichoblastic carcinosarcoma. Currently, two theories exist regarding its evolution.…”