Metabolic and morphological measurements of subcutaneous and visceral fat and their relationship with disease stage and overall survival in newly diagnosed pancreatic adenocarcinoma

Wiele, Christophe Van de; Vlaenderen, Mathias Van; D’Hulst, Ludovic; Delcourt, A.; Copin, Dominique; Spiegeleer, Bart De; Maes, Alex

doi:10.1007/s00259-016-3525-z

Cited by 14 publications

(18 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased inflammatory response in VAT, which can lead to increased FDG uptake of VAT, has been considered to be the underlying mechanism of these associations . On the contrary, other previous studies having patients with non‐small cell lung cancer and pancreatic cancer failed to show significant association between the FDG uptake of adipose tissue and survival . In our study, although VAT SUV had significant association with VAT HU and T classification, suggesting that VAT SUV could reflect the qualitative changes of VAT, it did not show significant association with survival on multivariate analysis after adjusting the covariates.…”

Section: Discussioncontrasting

confidence: 89%

“…In addition, the FDG uptake of VAT can reflect impaired metabolism of VAT in obese subjects . On the other hand, the clinical implication of the FDG uptake of adipose tissue in patients with malignant diseases has only been evaluated in a few studies, the results of which were inconsistent . In studies having patients with colorectal cancer, the FDG uptake of VAT was significantly associated with recurrence‐free survival as well as the FDG uptake of primary tumor and the presence of lymph node and distant organ metastases, showing aggressive tumor characteristics and worse survival in patients with high VAT .…”

Section: Discussionmentioning

confidence: 99%

“…The CT‐attenuation of adipose tissue is known to be related to inflammatory and fibrotic changes of adipose tissue . The FDG uptake of adipose tissue reflects both the glucose metabolism for lipogenesis process in adipocytes and inflammatory condition in adipose tissue . Recent studies have demonstrated that these two imaging parameters are associated with tumor characteristics and prognosis in various types of malignancies, including lung cancer, extremity sarcoma, and colorectal cancer .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Visceral adipose tissue volume and CT‐attenuation as prognostic factors in patients with head and neck cancer

et al. 2019

View full text Add to dashboard Cite

Background The aim of this study was to evaluate the relationship of the characteristics of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) to the disease progression‐free survival and distant failure‐free survival of head and neck squamous cell carcinoma (HNSCC). Methods We enrolled 152 HNSCC patients who underwent staging 18F‐fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT). Maximum FDG uptake (standardized uptake value [SUV]) and total lesion glycolysis (TLG) of the primary tumor and volume, CT‐attenuation (Hounsfield units [HU]), and FDG uptake of SAT and VAT were measured. Survival analysis using Cox proportional hazard modeling was performed to assess the relationship between the adipose tissue parameters of PET/CT and survival. Results Patients with low VAT volume and high VAT HU had significantly worse progression‐free survival and distant failure‐free survival than those with high VAT volume and low VAT HU. On multivariate analysis, the volume and HU of VAT were significantly correlated with disease progression‐free survival and distant failure‐free survival after adjusting for age, sex, body mass index, TNM stage, serum C‐reactive protein, maximum SUV, and TLG. Conclusion The volume and CT‐attenuation of VAT were significantly correlated with disease progression‐free survival and distant failure‐free survival in patients with HNSCC.

show abstract

Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Visceral adipose tissue volume and CT‐attenuation as prognostic factors in patients with head and neck cancer

et al. 2019

View full text Add to dashboard Cite

show abstract

“…However, the report of Van de Wiele et al is the first one demonstrating not only morphology for this purpose but also glucose metabolism estimated by FDG PET/CT [14]. Based on metabolic imaging they describe a different metabolism of visceral and subcutaneous fat tissue.…”

Section: Adipose Tissue As a Secretory Organmentioning

confidence: 99%

Editorial: Listen to your belly, fat is not your foe!

Kotzerke

Zöphel

2016

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

“…Imaging modalities such as magnetic resonance imaging (MRI) and X-ray computed tomography (CT) are both reliable methods for the assessment of abdominal adipose tissue volume [16] [17][18][19][20][21][22][23][24][25][26][27]. Overall, there is a growing interest in quantifying VAT as a CV risk marker and as a readout for therapeutic approaches [22,28,29].…”

Section: Introductionmentioning

confidence: 99%

Performance Evaluation of a Semi-automated Method for [18F]FDG Uptake in Abdominal Visceral Adipose Tissue

et al. 2018

View full text Add to dashboard Cite

Purpose: Severity of abdominal obesity and possibly levels of metabolic activity of abdominal visceral adipose tissue (VAT) are associated with an increased risk for cardiovascular disease (CVD). In this context, the purpose of the current study was to evaluate the reproducibility and repeatability of a semi-automated method for assessment of the metabolic activity of VAT using 2-deoxy-2-[ PET/low-dose (LD) CT scans within 1 week were included. Abdominal VAT was automatically segmented using CT between levels L1-L5. The initial CT-based segmentation was further optimized using PET data with a standardized uptake value (SUV) threshold approach (range 1.0-2.5) and morphological erosion (range 0-5 pixels). The [ 18 F]FDG uptake in SUV that was measured by the automated method was compared with manual analysis. The reproducibility and repeatability were quantified using intraclass correlation coefficients (ICCs).Results: The metabolic assessment of VAT on [ 18 F]FDG PET/LDCT scans expressed as SUV mean , using an automated method showed high inter and intra observer (all ICCs 9 0.99) and overall repeatability (ICC = 0.98). The manual method showed reproducible inter observer (all ICCs 9 0.92), but less intra observer (ICC = 0.57) and less overall repeatability (ICC = 0.78) compared with the automated method.

show abstract

Metabolic and morphological measurements of subcutaneous and visceral fat and their relationship with disease stage and overall survival in newly diagnosed pancreatic adenocarcinoma

Cited by 14 publications

References 22 publications

Visceral adipose tissue volume and CT‐attenuation as prognostic factors in patients with head and neck cancer

Visceral adipose tissue volume and CT‐attenuation as prognostic factors in patients with head and neck cancer

Editorial: Listen to your belly, fat is not your foe!

Performance Evaluation of a Semi-automated Method for [18F]FDG Uptake in Abdominal Visceral Adipose Tissue

Contact Info

Product

Resources

About