“…Remarkably, we report no significant differences in the global HPV infection rate nor in global infection by high-risk HPV between the vaccinated and the non-vaccinated groups, coinciding with that reported by Carozzi et al [ 13 ]. This can be explained by the high prevalence of other types (both high and low risk) that counteract the decrease demonstrated for genotypes HPV 6 and 16.…”
Section: Discussionsupporting
confidence: 92%
“…Additionally, in a similar report in the culturally close Italian population, Carozzi et al (2016) found a HR-HPV infection prevalence 8% lower than we do for a comparable age group [ 13 ].…”
A fully government-funded human papillomavirus (HPV) vaccination program started in 2007 in Spain (only 11–14-year-old girls). The first of those vaccinated cohorts, with the quadrivalent vaccine (Gardasil), turned 25 years old in 2018, the age at which cervical cancer screening begins in Spain. The current study could provide the first evidence about the effectiveness of the quadrivalent vaccine against HPV in Spain and the influence of age of vaccination. The present ambispective cohort study, which was conducted on 790 women aged 25 and 26 years old, compares the rate of HPV prevalence and cytologic anomaly according to the vaccination status. The overall infection rate was 40.09% (vaccinated group) vs. 40.6% (non-vaccinated group). There was a significant reduction in the prevalence of HPV 6 (0% vs. 1.3%) and 16 (2.4% vs. 6.1%), and in the prevalence of cytological abnormalities linked to HPV16: Atypical Squamous Cells of Undetermined Significance (ASCUS) (2.04% vs. 14%), Low-grade Squamous Intraepithelial Lesions (LSIL) (2.94% vs. 18.7%) and High-grade Squamous Intraepithelial Lesion (HSIL) (0% vs. 40%), in the vaccinated group vs. the non-vaccinated group. Only one case of HPV11 and two cases of HPV18 were detected. The vaccine effectively reduces the prevalence of vaccine genotypes and cytological anomalies linked to these genotypes.
“…Remarkably, we report no significant differences in the global HPV infection rate nor in global infection by high-risk HPV between the vaccinated and the non-vaccinated groups, coinciding with that reported by Carozzi et al [ 13 ]. This can be explained by the high prevalence of other types (both high and low risk) that counteract the decrease demonstrated for genotypes HPV 6 and 16.…”
Section: Discussionsupporting
confidence: 92%
“…Additionally, in a similar report in the culturally close Italian population, Carozzi et al (2016) found a HR-HPV infection prevalence 8% lower than we do for a comparable age group [ 13 ].…”
A fully government-funded human papillomavirus (HPV) vaccination program started in 2007 in Spain (only 11–14-year-old girls). The first of those vaccinated cohorts, with the quadrivalent vaccine (Gardasil), turned 25 years old in 2018, the age at which cervical cancer screening begins in Spain. The current study could provide the first evidence about the effectiveness of the quadrivalent vaccine against HPV in Spain and the influence of age of vaccination. The present ambispective cohort study, which was conducted on 790 women aged 25 and 26 years old, compares the rate of HPV prevalence and cytologic anomaly according to the vaccination status. The overall infection rate was 40.09% (vaccinated group) vs. 40.6% (non-vaccinated group). There was a significant reduction in the prevalence of HPV 6 (0% vs. 1.3%) and 16 (2.4% vs. 6.1%), and in the prevalence of cytological abnormalities linked to HPV16: Atypical Squamous Cells of Undetermined Significance (ASCUS) (2.04% vs. 14%), Low-grade Squamous Intraepithelial Lesions (LSIL) (2.94% vs. 18.7%) and High-grade Squamous Intraepithelial Lesion (HSIL) (0% vs. 40%), in the vaccinated group vs. the non-vaccinated group. Only one case of HPV11 and two cases of HPV18 were detected. The vaccine effectively reduces the prevalence of vaccine genotypes and cytological anomalies linked to these genotypes.
“…Although the prevalence of HPV infection in young women is high, most of HPV infection may be cleared automatically within 1‐2 years, so the prevalence of HPV infection would be reduced. The immune ability declined with age in old women, especially in the premenopausal and postmenopausal women, the ability in eliminating previous and new infections weakened, so the high prevalence of HPV infection was also in older women …”
Human papillomavirus (HPV) infection which continues to be the most common sexually transmitted disease, has been identified as a major risk factor for cervical cancer. Therefore, it is very important to understand and grasp the distribution of HPV in Chinese population, and make the foundation for the development of cervical cancer vaccine in China. An extensive search strategy was conducted in multiple literature databases. All retrieved studies were screened by October 31, 2018. The prevalence of HPV infection was analyzed using random effects model. A total of 68 studies satisfied the inclusion criteria for our study. The national overall prevalence of HPV infection was 15.54% (95% CI: 13.83%‐17.24%). we also performed subgroup analysis by age, geographic location, level of economic development, HPV assay method, and type of HPV infection. The top 5 common HPV types detected in general population, were HPV 16 (3.52%, 95% CI: 3.18%‐3.86%), 52 (2.20%, 95% CI: 1.93%‐2.46%), 58 (2.10%, 95% CI: 1.88%‐2.32%), 18 (1.20%, 95% CI: 1.05%‐1.35%), and 33 (1.02%, 95% CI: 0.89%‐1.14%). Except for the higher prevalence of HPV infection in 2009 and 2010, the prevalence of HPV infection in other years changed little, ranged from 13.2% to 17.4%. HPV type in Chinese women was quite distinctive. HPV infection played a critical role in the occurrence of cervical cancer, understanding the distribution of HPV type and performing the HPV type testing had important clinical value for colposcopy referral and increasing the detection rate. Therefore, our findings could provide evidence for cervical cancer screening and vaccine, in order to reduce the burden of cervical cancer.
“…Sería interesante estudiar la viabilidad de vacunar mujeres adultas con alto riesgo que resulten VPH negativo para los genotipos vacunales, para mostrar el posible impacto de la inmunización en la reducción de casos de CCU. En Italia recientemente se evaluaron tres grupos de mujeres de 25 años (mujeres sin previa prueba de ADN, mujeres VPH-16 y VPH-18 negativos y mujeres VPH-AR negativos), por la técnica molecular HC2 mostrando reducción en la prevalencia de infección por genotipos de alto riesgo tanto en el grupo de mujeres VPH-16 y VPH-18 negativas como en las VPH-AR negativas y reducción de lesiones citológicas después de la aplicación de dos dosis de la vacuna tetravalente en estos dos grupos de estudio 26 .…”
Introducción: La infección persistente con Virus de Papiloma Humano de alto riesgo es causa necesaria para la aparición de cáncer de cérvix. Objetivo: Caracterizar molecularmente los genotipos circulantes de Virus de Papiloma Humano en población de la zona Norte de Bucaramanga. Métodos: Estudio de corte transversal en mujeres de 35 a 65 años con riesgo ≥3 puntos para desarrollar cáncer de cérvix determinado por una encuesta estandarizada. En una muestra cervico-vaginal por autotoma se realizaron pruebas moleculares por tecnología HPV Direct Flow CHIP. Resultados: Se encuestaron 810 mujeres, de éstas 435 (53,7%) se realizaron auto-toma por el riesgo presentado. La mediana de edad fue de 47,3 años (RIQ 41-53 años). Casi la totalidad de la población reside en estrato 1 y 2 (98,8%) y en su mayoría son del régimen subsidiado (87,2%). La prevalencia de infección fue de 10,6% (IC 95%: 7,8-13,8), para genotipos de alto riesgo fue de 3,9% (IC 95%: 2,3-6,2), de bajo riesgo de 3,5% (IC 95%: 1,4-5,6) y para genotipo indeterminado de 1,9%. El genotipo de alto riesgo más común fue VPH-59 y de bajo riesgo fue VPH-62/81. Hubo coinfección con genotipos alto/bajo riesgo en cinco mujeres y coinfección con dos genotipos de bajo riesgo en una mujer. Conclusión: la prevalencia de infección por Virus de Papiloma Humano en mujeres que habitan en zonas vulnerables de Bucaramanga es menor a la reportada en Bogotá y Cali (14,9% y 13%, respectivamente). No se encontró predominio de ningún genotipo de alto riesgo en particular. Palabras clave: Cáncer de cuello uterino; Técnicas de diagnóstico molecular; Pruebas de ADN del Papillomavirus Humano; Detección precoz del cáncer; Estudios transversales.
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