pH and redox dual-responsive biodegradable polymeric micelles with high drug loading for effective anticancer drug delivery

Teo, Joseph Chee Ming; Chin, Willy; Ke, Xiyu; Gao, Shujun; Liu, Shaoqiong; Cheng, Wei; Hedrick, James L.; Yang, Yi Yan

doi:10.1016/j.nano.2016.09.016

Cited by 69 publications

(26 citation statements)

References 45 publications

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“…DOX showed relatively low absorption (45%) as compared to DNR (77.5%). However, DOX presented high loading efficiency and loading capacity of 55% (550 mg g -1 ) and 27.5% (275 mg g -1 ) relative to DNR, 22.5% (225 mg g -1 ) and 11.25% (112.5 mg g -1 ) (Teo et al 2017). The DOX-and DNR-loaded Ag-NPs showed efficient and remarkable loading efficiency (55, 22.5)% and capacity (27.5, 11.25)%, respectively…”

Section: Anthelmintic Activitymentioning

confidence: 96%

Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer

et al. 2017

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The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet-visible (UV-Vis) spectrophotometry. Anticancer activity of AgNPs (5-20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P \ 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.

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Section: Anthelmintic Activitymentioning

confidence: 96%

Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer

et al. 2017

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“…Redox responsive PTs include dual-responsive Dox loaded micelles of PEG-polycarbonate diblock copolymers functionalized with disulfide bonds and pH-responsive carboxylic acid groups [ 159 ], PEG-modified redox-responsive chain-shattering polymeric therapeutic (CSPT) drug carriers [ 160 ] and additional PUMPT strategies [ 161 ].…”

Section: Hurdle 3: Intracellular Release Of Active Agentmentioning

confidence: 99%

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment

Atkinson

Andreu

Vicent

2018

JPM

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Polymer therapeutics (PTs) provides a potentially exciting approach for the treatment of many diseases by enhancing aqueous solubility and altering drug pharmacokinetics at both the whole organism and subcellular level leading to improved therapeutic outcomes. However, the failure of many polymer-drug conjugates in clinical trials suggests that we may need to stratify patients in order to match each patient to the right PT. In this concise review, we hope to assess potential PT-specific biomarkers for cancer treatment, with a focus on new studies, detection methods, new models and the opportunities this knowledge will bring for the development of novel PT-based anti-cancer strategies. We discuss the various “hurdles” that a given PT faces on its passage from the syringe to the tumor (and beyond), including the passage through the bloodstream, tumor targeting, tumor uptake and the intracellular release of the active agent. However, we also discuss other relevant concepts and new considerations in the field, which we hope will provide new insight into the possible applications of PT-related biomarkers.

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“…The success of these drugs depends on the fabrication of bioavailability carriers with high drug loading capabilities and no early release [165]. The drug delivery agent should have a compatibility with the drug [166], be capable of encapsulation [167], feature high drug loading [168], and have the appropriate release rate [169]. Due to their importance, changeless drug delivery systems are focused structurally so that drug materials are transmitted without immediate release to the target site [165].…”

Section: Application Of Silica Mesopores In Drug Deliverymentioning

confidence: 99%

Silica Mesoporous Structures: Effective Nanocarriers in Drug Delivery and Nanocatalysts

et al. 2020

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The application of silica mesoporous structures in drug delivery and the removal of pollutants and organic compounds through catalytic reactions is increasing due to their unique characteristics, including high loading capacities, tunable pores, large surface areas, sustainability, and so on. This review focuses on very well-studied class of different construction mesoporous silica nano(particles), such as MCM-41, SBA-15, and SBA-16. We discuss the essential parameters involved in the synthesis of these materials with providing a diverse set of examples. In addition, the recent advances in silica mesoporous structures for drug delivery and catalytic applications are presented to fill the existing gap in the literature with providing some promising examples on this topic for the scientists in both industry and academia active in the field. Regarding the catalytic applications, mesoporous silica particles have shown some promises to remove the organic pollutants and to synthesize final products with high yields due to the ease with which their surfaces can be modified with various ligands to create appropriate interactions with target molecules. In the drug delivery process, as nanocarriers, they have also shown very good performance thanks to the easy surface functionalization but also adjustability of their porosities to providing in-vivo and in-vitro cargo delivery at the target site with appropriate rate.

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pH and redox dual-responsive biodegradable polymeric micelles with high drug loading for effective anticancer drug delivery

Cited by 69 publications

References 45 publications

Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer

Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer

Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment

Silica Mesoporous Structures: Effective Nanocarriers in Drug Delivery and Nanocatalysts

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