Hypertriglyceridemia: the importance of identifying patients at risk

Kushner, Pamela A; Cobble, Michael

doi:10.1080/00325481.2016.1243005

Cited by 29 publications

(23 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Notably, these populations differ in relation to life-styles and risks of CVD. Moreover, the data from the CONOR-survey consistently showed that sHTG level was associated with a number of risk factors for CVD, diabetes and the metabolic syndrome, as evidenced by elevated glucose, blood pressure, BMI as well as low physical activity [17]. If these risk factors represent potential causes or consequences of sHTG or if they are associated phenomena reflecting common pathogenic mechanisms such as those leading to metabolic syndromes, are at present not known.…”

Section: Discussionmentioning

confidence: 99%

Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics

Retterstøl¹,

Narverud²,

Selmer³

et al. 2017

Lipids Health Dis

View full text Add to dashboard Cite

BackgroundThere is a lack of comprehensive patient-datasets regarding prevalence of severe hypertriglyceridemia (sHTG; triglycerides ≥10 mmol/L), frequency of co-morbidities, gene mutations, and gene characterization in sHTG. Using large surveys combined with detailed analysis of sub-cohorts of sHTG patients, we here sought to address these issues.MethodsWe used data from several large Norwegian surveys that included 681,990 subjects, to estimate the prevalence. Sixty-five sHTG patients were investigated to obtain clinical profiles and candidate disease genes. We obtained peripheral blood mononuclear cells (PBMC) from six male patients and nine healthy controls and examined expression of mRNAs involved in lipid metabolism.ResultsThe prevalence of sHTG was 0.13 (95% CI 0.12-0.14)%, and highest in men aged 40-49 years and in women 60-69 years. Among the 65 sHTG patients, a possible genetic cause was found in four and 11 had experienced acute pancreatitis. The mRNA expression levels of carnitine palmitoyltransferase (CPT)-1A, CPT2, and hormone-sensitive lipase, were significantly higher in patients compared to controls, whereas those of ATP-binding cassette, sub-family G, member 1 were significantly lower.ConclusionsIn Norway, sHTG is present in 0.1%, carries considerable co-morbidity and is associated with an imbalance of genes involved in lipid metabolism, all potentially contributing to increased cardiovascular morbidity in sHTG.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0511-9) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics

Retterstøl¹,

Narverud²,

Selmer³

et al. 2017

Lipids Health Dis

View full text Add to dashboard Cite

show abstract

“…Hypertriglyceridemia is often associated with T1DM and T2DM [134][135][136]. Cholesterol ester transfer protein (CETP) exchanges cholesterol and triglycerides between very low-density lipoprotein and HDL [137].…”

Section: Changes In Lipid Metabolism At the Origin Of Atherosclerosismentioning

confidence: 99%

Coagulatory Defects in Type-1 and Type-2 Diabetes

Sobczak

Stewart

2019

IJMS

View full text Add to dashboard Cite

Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.

show abstract

“…To rule out other causes, we only include patients without any familial dyslipidemia or history of alcohol intake. As these two factors also play a role in increasing triglycerides as compared to polygenic etiologies like obesity, insulin resistance or diabetes mellitus [10-11]. …”

Section: Introductionmentioning

confidence: 99%

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Naqvi

Naveed

Ali

et al. 2017

Cureus

View full text Add to dashboard Cite

ContextDyslipidemia is quite prevalent in non-insulin dependent diabetes mellitus. Maintaining tight glycemic along with lipid control plays an essential role in preventing micro- and macro-vascular complications associated with diabetes. PurposeThe main purpose of the study was to highlight the relationship between glycosylated hemoglobin (HbA1c) and triglyceride levels. This may in turn help in predicting the triglyceride status of type 2 diabetics and therefore identifying patients at increased risk from cardiovascular events. Hypertriglyceridemia is one of the common risk factors for coronary artery disease in type 2 diabetes mellitus (DM). Careful monitoring of the blood glucose level can be used to predict lipid status and can prevent most of the complications associated with the disease.MethodThis is a cross-sectional study using data collected from the outpatient diabetic clinic of Jinnah Postgraduate Medical Centre (JPMC) Karachi, Pakistan. Patients of age 18 years and above were recruited from the clinic. A total of consenting 509 patients of type 2 diabetes mellitus were enrolled over a period of 11 months. For statistical analysis, SPSS Statistics for Windows, Version 17.0 ( IBM Corp, Armonk, New York) was used and Chi-square and Pearson’s correlation coefficient was used to find the association between triglyceride and HbA1c. The HbA1c was dichotomized into four groups on the basis of cut-off. Chi-square was used for association between HbA1c with various cut-off values and high triglyceride levels. Odds-ratio and its 95% confidence interval were calculated to estimate the level of risk between high triglyceride levels and HbA1c groups. The p-value < 0.05 was considered statistically significant for all the tests applied for significance.ResultThe association of high triglyceride was evaluated in four different groups of HbA1c, with a cut-off seven, eight, nine and 10 respectively. With HbA1c cut-off value of 7%, 74% patients had high triglycerides and showed a significant association with high triglyceride levels at p < 0.001 and odds ratio was 2.038 (95% confidence interval: 1.397 – 2.972). Logistic regression models were adjusted for demographic factors (age, race, gender), lifestyle factors (smoking, body mass index, lifestyle) and health status factors (blood pressure, physician-rated health status).ConclusionAfter adjusting for relevant covariates, glycated hemoglobin was positively correlated with high triglyceride. Hence, HbA1c can be an indicator of triglyceride level and can be one of the predictors of cardiovascular risk factors in type 2 diabetes mellitus.

show abstract

Hypertriglyceridemia: the importance of identifying patients at risk

Cited by 29 publications

References 65 publications

Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics

Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics

Coagulatory Defects in Type-1 and Type-2 Diabetes

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About