Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline

Basambombo, Luta Luse; Carmichael, Pierre‐Hugues; Côté, Sharlène; Laurin, Danielle

doi:10.1177/1060028016673072

Cited by 69 publications

(41 citation statements)

References 37 publications

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“…A number of previous studies found that total flavonoid intake was associated with slower cognitive decline or reduced dementia risk [9,10,17,32]. There are mixed findings for vitamin C intake and risk of Alzheimer's dementia, with some finding protective associations [10,33] and others no association [7,8]. We did not find any association between total vitamin C intake from food as well as supplements and Alzheimer's dementia risk.…”

Section: Discussioncontrasting

confidence: 80%

Association of Strawberries and Anthocyanidin Intake with Alzheimer’s Dementia Risk

et al. 2019

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Background: Strawberries have been identified to have antioxidant and anti-inflammatory properties that improve neuronal function and cognition, mostly in animal studies. It is unknown if the consumption of strawberries or related bioactives may reduce the risk of Alzheimer’s dementia risk. Material and Methods: The study was conducted in 925 participants, aged 58–98 years of the Rush Memory and Aging Project. Participants were dementia-free at baseline, completed a food frequency questionnaire, and had at least two annual neurological evaluations. The diagnosis of Alzheimer’s dementia was based on structured clinical neurological examination and standardized diagnostic criteria. The association of strawberry intake and incident Alzheimer’s dementia was analyzed using proportional hazard models adjusted for age, sex, education, physical activity, participation in cognitive activities, APOE-ɛ4 genotype, dietary intake of other fruits, and total calorie intake. Results: A total of 245 participants developed Alzheimer’s dementia over the mean follow-up of 6.7 (±3.6) years. Higher strawberry intake was associated with reduced risk of Alzheimer’s dementia (HR = 0.76, 95% CI: 0.60–0.96). In separate adjusted models, highest vs. lowest quartile intakes of Vitamin C (HR = 0.64, 95% CI: 0.45, 0.92), Pelargonidin (0.63, 95% CI: 0.43, 0.92), total anthocyanidins (0.69, 95% CI: 0.48, 0.99), and total flavonoids (0.67, 95% CI: 0.46, 0.98) were each associated with lower Alzheimer’s dementia risk. These associations remained after further adjustment for cardiovascular conditions. Conclusion: Consumption of strawberries and foods rich in vitamin C, pelargonidin, anthocyanidins, and total flavonoids may reduce the risk of Alzheimer’s dementia.

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Section: Discussioncontrasting

confidence: 80%

Association of Strawberries and Anthocyanidin Intake with Alzheimer’s Dementia Risk

et al. 2019

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“…Studies have suggested that vitamin C may be able to halt the development of AD due to its role in mitigating various processes associated with AD pathology [81]. Both in vitro and in vivo studies have reported that vitamin C helps reduce OS by impeding Aß oligomerization [11,15]. Damage to the brain leads to a decline in antioxidants and important enzymes, including vitamin C and superoxide dismutase (SOD), which neutralizes O 2…”

Section: Alzheimer's Disease and Nutrientsmentioning

confidence: 99%

“…Ac cordingly, antioxidant treatments can facilitate neuroprotection by delaying the occurrence or even reversing OS in some cases [14]. In addition, diet is known to play a key role in neurodegenerative diseases, and the development of irreversible neurocognitive decline can be prevented or delayed by the consumption of certain nutrients and appropriate dietary modi ications [15,16]. Therefore, nutrients known to be useful in mitigating or counteracting ROS in neurodegenerative disorders will also be discussed.…”

Section: Introductionmentioning

confidence: 99%

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Madireddy¹,

Madireddy²

2019

J Neurosci Neurol Disord

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Vitamin E Antioxidant, Neuroprotection Vitamin E is a scavenger of several ROS and serves to reduce their reactivity and toxicity. It offers protection from the propagative damage of ROS by inhibiting the oxidative modifi cation of lipoproteins AD [74-79,82-86] PD [175-177,79] ALS [193,217,218] Vitamin C Antioxidant, Neuroprotection Vitamin C is an excellent antioxidant, suitable in reducing ROS levels, lipid peroxidation, and oxidative stress. It is also useful in regenerating other antioxidants. AD [81,82,75,77,79] PD [166-168] ALS [213,214] Vitamin D Antioxidant Neuroprotection Vitamin D prevent oxidative stress, lower the production of free radicals, and reduce neurotoxicity through the enhancement of autophagy signaling pathways AD [74-78,30,16,80] PD [157-159,169-174] ALS [215,216] Vitamin A Antioxidan Vitamin A prevent the formation of Aβ plaques AD [16,30,74-78] Vitamin B Antioxidant Neuroprotection Vitamin B perform antioxidant and neuroprotective functions AD [88-90] PD [157-159,162-165] HD [105] Curcumin Antioxidant Anti-infl ammatory Neuroprotection Curcumin is a scavenger of free radicals and reduces mitochondrial disfunction. AD [100,101] Omega−3 fatty acids Antioxidant Anti-infl ammatory Omega-3 fatty acids reduce ROS formation acting as free radical scavengers.

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“…It was shown that none of the individuals supplemented with ascorbic acid had Alzheimer's disease over the follow‐up period (mean of 4 years). Basambombo et al recently evaluated whether the use of vitamins E and C supplements is associated with reduced risks of cognitive impairment, dementia, Alzheimer's disease, or all‐cause dementia in a sample of 5269 persons ≥65 years old. Compared with those not taking vitamin supplements, individuals using vitamin E and/or vitamin C supplements presented reduced risk of cognitive decline and Alzheimer's disease.…”

Section: Role Of Ascorbic Acid In Neurodegenerative Diseasesmentioning

confidence: 99%

Preventive and therapeutic potential of ascorbic acid in neurodegenerative diseases

2017

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In this review, we summarize the involvement of ascorbic acid in neurodegenerative diseases by presenting available evidence on the behavioral and biochemical effects of this compound in animal models of neurodegeneration as well as the use of ascorbic acid as a therapeutic approach to alleviate neurodegenerative progression in clinical studies. Ascorbate, a reduced form of vitamin C, has gained interest for its multiple functions and mechanisms of action, contributing to the homeostasis of normal tissues and organs as well as to tissue regeneration. In the brain, ascorbate exerts neuromodulatory functions and scavenges reactive oxygen species generated during synaptic activity and neuronal metabolism. These are important properties as redox imbalance and abnormal protein aggregation constitute central mechanisms implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, multiple sclerosis, and amyotrophic lateral sclerosis. Indeed, several studies have indicated an association between low serum ascorbate concentrations and neurodegeneration. Moreover, ascorbic acid is a suitable candidate for supplying either antioxidant defense or modulation of neuronal and astrocytic metabolism under neurodegenerative conditions. Ascorbic acid acts mainly by decreasing oxidative stress and reducing the formation of protein aggregates, which may contribute to the reduction of cognitive and/or motor impairments observed in neurodegenerative processes. Although several studies support a possible role of ascorbic acid administration against neurodegeneration, more researches are essential to substantiate the existing results and accelerate the knowledge in this field.

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Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline

Abstract: This analysis suggests that the use of vitamin E and C supplements is associated with a reduced risk of cognitive decline. Further investigations are needed to determine their value as a primary prevention strategy.

Cited by 69 publications

References 37 publications

Association of Strawberries and Anthocyanidin Intake with Alzheimer’s Dementia Risk

Association of Strawberries and Anthocyanidin Intake with Alzheimer’s Dementia Risk

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Preventive and therapeutic potential of ascorbic acid in neurodegenerative diseases

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