Mutagenic potential assessment associated with human exposure to natural radioactivity

Marcon, Alexandre Endres; Navoni, Júlio Alejandro; Galvão, Marcos Felipe de Oliveira; Garcia, Anuska Conde Fagundes Soares; Amaral, Viviane Souza do; Petta, Reinaldo Antônio; Campos, Thomas Ferreira da Costa; Panosso, Renata; Quinelato, A. L.; Medeiros, Sílvia Regina Batistuzzo de

doi:10.1016/j.chemosphere.2016.09.136

Cited by 17 publications

(8 citation statements)

References 61 publications

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“…Meanwhile, Aphanocapsa, a coccoid cyanobacterium typically found in eutrophic environments (Padisák et al, 2009), was detected under mesotrophic conditions and associated to lower suspended solids and deeper water depth (Zmax). Although the dominance of Aphanocapsa was rare in the studied lakes, microcystin-producing variants of this genus have been frequently found in other semiarid man-made lakes (Domingos et al, 1999;Marcon et al, 2017), making it a potential threat to water quality.…”

Section: Discussionmentioning

confidence: 92%

Abiotic factors driving cyanobacterial biomass and composition under perennial bloom conditions in tropical latitudes

et al. 2021

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While warming and eutrophication have increased the frequency and magnitude of harmful cyanobacterial blooms globally, the scenario for many eutrophic tropical freshwaters is a perennial year-round bloom. Yet, the drivers of persistent blooms are less understood when conditions such as light, temperature, and nutrients favor cyanobacteria growth year-round, and especially in regions facing recurrent periods of drought. In order to understand the drivers of cyanobacteria dominance, we assessed the abiotic conditions related to the abundance and dominance of the two dominant bloom-forming genera Raphidiopsis and Microcystis, in six shallow, man-made lakes located in the semiarid Northeastern region of Brazil during a prolonged regional drought. Lower water level corresponded to increased phosphorous and nitrogen concentration and, consequently, phytoplankton biomass. Cyanobacterial biomass was also proportional to phosphorus concentrations during year-round blooms. Yet, the two dominant cyanobacterial genera, Raphidiopsis and Microcystis, seldom co-occurred temporally and the switch between them was driven by water transparency. Our results illustrate the effects of drought induced water level reductions on the biomass and composition of cyanobacterial blooms in tropical shallow man-made lakes. Given the ideal year-round conditions (i.e., high light and temperature), droughts may be expected to intensify the risk and multitude of problems associated with eutrophication.

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Section: Discussionmentioning

confidence: 92%

Abiotic factors driving cyanobacterial biomass and composition under perennial bloom conditions in tropical latitudes

et al. 2021

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“…Studies related to genome stability are not an easy task, as they are biased by many confounding factors, often giving inconsistent results or of low statistical strength that enable a direct attribution of the disease to examined factors. Nevertheless, in some cases, such studies could be conclusive, e.g., studies on a role of radon-induced DNA damage in development of lung cancer, impact of PM-10 and PM-2.5 dusts on human health, cytogenetic effects of unhealthy nutrition or effects of risky, unhealthy behaviors and addictions, such as smoking cigarettes or chewing betel quid [12][13][14][15][16].…”

Section: Why Do We Need Genotoxicity Testing Biomonitoring Cytogenementioning

confidence: 99%

“…BMn seems to be advantageous over other types of MN to study how genotoxic factors affect organisms by inhalation. It is the only method capable to show genotoxic effects of moderate concentrations of radon, as those that are met in unventilated rooms, basements or caves [14,97]. Moreover, the sensitivity of BMn allowed also to show genotoxic effects of work in healthcare, where staff was exposed to very low doses of radiation [98].…”

Section: Buccal Mn (Bmm)-mature But Underused Assaymentioning

confidence: 99%

Micronucleus Assay: The State of Art, and Future Directions

Sommer

Buraczewska

Kruszewski

2020

IJMS

191

112

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During almost 40 years of use, the micronucleus assay (MN) has become one of the most popular methods to assess genotoxicity of different chemical and physical factors, including ionizing radiation-induced DNA damage. In this minireview, we focus on the position of MN among the other genotoxicity tests, its usefulness in different applications and visibility by international organizations, such as International Atomic Energy Agency, Organization for Economic Co-operation and Development and International Organization for Standardization. In addition, the mechanism of micronuclei formation is discussed. Finally, foreseen directions of the MN development are pointed, such as automation, buccal cells MN and chromothripsis phenomenon.

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“…Из рисунка 1 следует, что относительные величины полученных доз в зависимости от амплитуды сигнала ЭПР эмали зубов двух районов практически не отличаются. Заслуживает внимания тот факт, что доза от 25-30 рад и более, обнаруженная у жителей обследованных регионов, в среднем превышает среднестатистические дозы для ана-логичных территорий [9][10][11][12]. Для определения активности радионуклидов в твердых тканях зубов нами проведены измерения бета-и гамма-активности в радиологической лаборатории Научно-практического центра санитарно-эпидемиологической экспертизы и мониторинга, г. Алматы, Казахстан.…”

Section: S U M M a R Y Human Teeth Enamel As A Test For Assessing The Consequences Of Radiation Pollution Of The Environmentunclassified

“…3). приведены и обсуждены несколько методов представления результатов гамма-спектрометрических измерений проб окружающей среды для расчета доз [9,11]. Было показано, что первичные результаты измерений, модифицированные в соответствии с пределом количественной оценки, могут привести к занижению годовой дозы.…”

Section: оригинальные исследования радиологияunclassified

Human teeth enamel as a test for assessing the consequences of radiation pollution of the environment

et al. 2021

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Technogenic radioactive contamination of the external environment has a radiation effect on flora and fauna, including humans. Radionuclides entering the biosphere become a source of external, contact and internal radiation in a variety of combinations. The electron paramagnetic resonance dosimetry is a technique that allows a retrospective assessment of an individual dose to be made. Purpose of the study. Assessment of the long-term consequences of the impact of radiation contamination of the territories adjacent to the landfill on the health of the population using biotesting methods. Material and methods. A reconnaissance and radioecological survey of environmental objects was carried out using analytical methods, which made it possible to determine the quantitative content of toxic components, priority pollutants and radioactive isotopes. The objects of study are the Bokeyordinsky and Zhanibeksky districts of the West Kazakhstan region (WKR), adjacent to the Kapustin Yar test site. The values of the volumetric activity of natural and technogenic radionuclides in soil samples, drinking water and biosubstrates (teeth, samples of human peripheral blood) from settlements of the surveyed areas were studied. Results and discussion. Measurements of gamma radiation showed that along the perimeter of the polygon and in nearby settlements, the radiation level is in the range of 0.06–0.14 µSv/h. An insignificant excess of the level of radioactivity persists near the fall of missiles in the Bokeyordin region. The indicators of the general morbidity of the adult population of maternal and child mortality in the indicated regions were also studied. It was found in the inhabitants of the Bokeyordinsky district with a reliability of p = 95% in the studied teeth, betta and gamma activity is less than the natural level and indicates that the content of radionuclides in the studied teeth is not higher than their natural level. A noticeable excess of the activity of radionuclides K40 and Ra226 is noted among residents of Zhanibeksky district. Conclusions. In the surveyed districts of the region, there is an unsatisfactory state of health of children and women, especially of fertile age, a high level of primary morbidity, maternal mortality; there is a tendency for the growth of eco-dependent human diseases (previously unrecorded forms of oncological diseases, congenital malformations, diseases of the hematopoietic and nervous systems). The conclusions can be used to implement measures to improve the ecological state of the region and the health of the population. Keywords: radionuclides, radioactivity, biosubstrate, polygon, ecology, eco-dependent diseases.

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Mutagenic potential assessment associated with human exposure to natural radioactivity

Cited by 17 publications

References 61 publications

Abiotic factors driving cyanobacterial biomass and composition under perennial bloom conditions in tropical latitudes

Abiotic factors driving cyanobacterial biomass and composition under perennial bloom conditions in tropical latitudes

Micronucleus Assay: The State of Art, and Future Directions

Human teeth enamel as a test for assessing the consequences of radiation pollution of the environment

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