Technical feasibility and tissue reaction after silicone-covered biodegradable magnesium stent insertion in the oesophagus: a primary study in vitro and in vivo

Zhang, Donghui; Edmonds, Laura; Wei, Liming; Zheng, Reila; Chen, Ruoyu; Cui, Wenguo; Cheng, Ying-Sheng

doi:10.1007/s00330-016-4602-1

Cited by 7 publications

(3 citation statements)

References 22 publications

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“… Yang et al (2019) ( Zhu et al, 2017 ) developed an Mg stent coated with silicon, which possessed excellent flexibility and elasticity and exhibited impressive resilience to lesion compression during in vivo testing. In their study, the research team inserted the stents into the healthy esophagi of rabbits and observed that they offered sufficient radial force, with the silicon membrane significantly decreasing the rate of Mg biodegradation.…”

Section: Materials Used In Biodegradable Esophageal Stentsmentioning

confidence: 99%

“…Therefore, future endeavors should focus on crafting composite coatings that harness the advantageous properties of each individual layer, thereby elevating the biological activity and adhesion of Mg-based stents ( Zhang et al, 2021 ). In addition, the effective support duration of covered Mg stents remains limited, partly owing to a relatively high migration rate ranging from 40% to 58.3% ( Yuan et al, 2016 ; Zhu et al, 2017 ; Yang et al, 2019 ; Liu et al, 2022 ). Addressing this issue necessitates further research focused on reducing the biodegradation rate and prolonging the duration of support.…”

Section: Materials Used In Biodegradable Esophageal Stentsmentioning

confidence: 99%

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Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents

Yang,

Hou

et al. 2023

Front. Bioeng. Biotechnol.

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Esophageal stricture (ES) results from benign and malignant conditions, such as uncontrolled gastroesophageal reflux disease (GERD) and esophageal neoplasms. Upper gastrointestinal endoscopy is the preferred diagnostic approach for ES and its underlying causes. Stent insertion using an endoscope is a prevalent method for alleviating or treating ES. Nevertheless, the widely used self-expandable metal stents (SEMS) and self-expandable plastic stents (SEPS) can result in complications such as migration and restenosis. Furthermore, they necessitate secondary extraction in cases of benign esophageal stricture (BES), rendering them unsatisfactory for clinical requirements. Over the past 3 decades, significant attention has been devoted to biodegradable materials, including synthetic polyester polymers and magnesium-based alloys, owing to their exceptional biocompatibility and biodegradability while addressing the challenges associated with recurring procedures after BES resolves. Novel esophageal stents have been developed and are undergoing experimental and clinical trials. Drug-eluting stents (DES) with drug-loading and drug-releasing capabilities are currently a research focal point, offering more efficient and precise ES treatments. Functional innovations have been investigated to optimize stent performance, including unidirectional drug-release and anti-migration features. Emerging manufacturing technologies such as three-dimensional (3D) printing and new biodegradable materials such as hydrogels have also contributed to the innovation of esophageal stents. The ultimate objective of the research and development of these materials is their clinical application in the treatment of ES and other benign conditions and the palliative treatment of malignant esophageal stricture (MES). This review aimed to offer a comprehensive overview of current biodegradable esophageal stent materials and their applications, highlight current research limitations and innovations, and offer insights into future development priorities and directions.

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Section: Materials Used In Biodegradable Esophageal Stentsmentioning

confidence: 99%

Section: Materials Used In Biodegradable Esophageal Stentsmentioning

confidence: 99%

Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents

Yang,

Hou

et al. 2023

Front. Bioeng. Biotechnol.

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“…Besides being targeted for endovascular stents, magnesium alloys were also utilized for esophageal stents. Zhu et al ( 2016 , 2017 ) successfully determined its feasibility through the implantation of silicone-covered magnesium esophageal stent (Fig. 4 d) in the esophagus of rabbits.…”

Section: Basic Researchmentioning

confidence: 99%

Updates on the research and development of absorbable metals for biomedical applications

2018

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Absorbable metals, metals that corrode in physiological environment, constitute a new class of biomaterials intended for temporary medical implant applications. The introduction of these metals has shifted the established paradigm of metal implants from preventing corrosion to its direct application. Interest toward absorbable metals has been growing in the past decade. This is proved by the rapid increase in scientific publication, progressive development of standards, and launching the first commercial products. Iron, magnesium, zinc, and their alloys are the current three absorbable metals families. Magnesium-based metals are the most progressing family with a large data set obtained from both basic and translational research. Iron-based metals are still facing a major challenge of low in vivo corrosion rate despite the significant efforts that have been put to overcome its weakness. Zinc-based metals are the new alternative absorbable metals with moderate corrosion rates that fall between those of iron and magnesium. This manuscript provides a brief review on the latest progress in the research and development of absorbable metals, the most important findings, the remaining challenges, and the perspective on the future direction.Graphical abstract

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Micro-endoscopy for Live Small Animal Fluorescent Imaging

Paulson

Kim

2021

Advances in Experimental Medicine and Biology

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Technical feasibility and tissue reaction after silicone-covered biodegradable magnesium stent insertion in the oesophagus: a primary study in vitro and in vivo

Abstract: • Mg stent provided apparently adequate radial force and silicone membrane reduced magnesium biodegradation • Stent insertion provided good support for at least 2 weeks before biodegradation • Stenting effectively resulted in oesophageal wall remodelling, without demonstrable injury.

Cited by 7 publications

References 22 publications

Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents

Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents

Updates on the research and development of absorbable metals for biomedical applications

Micro-endoscopy for Live Small Animal Fluorescent Imaging

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