“…Agents within drug class have been shown to inhibit the elimination of methotrexate, thereby leading to higher systemic concentrations that may, consequently, exacerbate the toxicity of methotrexate . Clinically significant drug‐drug interaction between high‐dose methotrexate, used in oncological conditions, and NSAIDs is a well‐recognized potential cause of serious methotrexate toxicity . While high‐ and low‐dose methotrexate differs with respect to potential for interaction, case reports and pharmacokinetic studies, although conflicting, have also suggested the possibility of clinically significant interaction with concomitant use of low‐dose methotrexate and NSAIDs.…”