277 Diltiazem Attenuates Cardiovascular Toxicities And Reduces Mortality Induced By Isoproterenol In A Freely Moving Rat Model In Vivo

Effect of acute exercise on cardiovascular hemodynamic and red blood cell concentrations of purine nucleotides in hypertensive compared with normotensives rats

“…Such a mechanism would eliminate the requirement for a diverse network of sensing sites throughout the vasculature, and should provide a more efficient means of appropriately matching oxygen supply with demand, and allow an immediate switch to alternative energy sources under hypoxia condition [Lopez-Barneo et al 2010]. We have recently shown that preconditioning with a brief 15 min treadmill exercise significantly reduced mortality induced by isoproterenol in SDRs in an acute myocardial infarction model in vivo [Yeung and Seeto, 2011]. Thus we advocate the beneficial effects of exercise are at least in part attributable to BP and HR lowering effects occurring after exercise, which are due to an increase in RBC concentrations of ATP and GTP.…”

“…2010]. We have recently shown that preconditioning with a brief 15 min treadmill exercise significantly reduced mortality induced by isoproterenol in SDRs in an acute myocardial infarction model in vivo [Yeung and Seeto, 2011]. Thus we advocate the beneficial effects of exercise are at least in part attributable to BP and HR lowering effects occurring after exercise, which are due to an increase in RBC concentrations of ATP and GTP.…”

Therapeutic Potential of Adenosine Transport Modulators for Cardiovascular Protection

“…It was suggested that the order of potency inhibiting adenosine uptake by erythrocytes is draflazine ≥ dilazep >R 75 231 >NBMPR > mioflazine = dipyridamole > lidoflazine [34]. Using mammalian cardiac myocytes, it was shown that adenosine attenuated the stimulatory effects of isoproterenol via blockade of calcium influx [35], which may explain at least partly the cardiovascular protective effect of calcium channel blockers [36], although these agents may also have a direct effect modulating the transport and metabolism of adenosine [37][38][39].…”

Natural Health Products as Modulators of Adenosine and ATP Metabolism for Cardiovascular Protection

“…It was suggested that the order of potency inhibiting adenosine uptake by RBC is draflazine ≥ dilazep >R75231>NBMPR>mioflazine=dipyridamole>lidoflazine [43]. Using mammalian cardiac myocytes, it was shown that adenosine attenuated the stimulatory effects of isoproterenol via blockade of calcium influx [44], which may explain at least partly the cardiovascular protective effect of calcium channel blockers [45][46][47][48], although these agents may also have a direct effect inhibiting the adenosine transporters [49].…”