277 Combination of irinotecan and capecitabine as first line treatment in advanced colorectal cancer (ACC): results of a phase II multicenter trial

Punt, Cornelis J. A.; Nortier, J.W.R.; Huinink, W.W. ten Bokkel; Falk, S.; Richel, D. J.; Maughan, T; Groenewegen, Gerard; Smith, Jason; Bakker, Johan; Rea, D

doi:10.1016/s1359-6349(03)90310-7

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“…Although dose adjustment is not recommended, close monitoring and careful examination of laboratory parameters including liver function should be performed in these patients . Even though there appeared to be no clinically relevant interactions between capecitabine and other anticancer drugs including paclitaxel, docetaxel and irinotecan, a number of other drugs, such as phenytoin, warfarin and birvudine, can potentially interact with capecitabine . The patient received warfarin and capecitabine concurrently from 2 March to 18 March 2013.…”

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confidence: 99%