Management of infection by the Zika virus

Falcão, Melissa Barreto; Cimerman, Sérgio; Luz, Kléber Giovanni; Chebabo, Alberto; Brigido, Helena Andrade; Lobo, Iza Maria Fraga; Timerman, Artur; Angerami, Rodrigo Nogueira; Cunha, Clóvis Arns da; Bacha, Hélio Arthur; Alves, Jesse Reis; Barbosa, Alexandre Naime; Teixeira, R.; Weissmann, Leonardo; Oliveira, Priscila Rosalba Domingos de; Cyrillo, Marco Antonio; Bandeira, António

doi:10.1186/s12941-016-0172-y

Cited by 22 publications

(22 citation statements)

References 42 publications

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“…ZIKV infection can often be asymptomatic, but when symptoms are present, they are usually mild. Symptoms such as fever, rash, or arthralgia are managed with plenty of rest, staying well hydrated by drinking plenty of fluids [88]. Pain and fever are treated with acetaminophen; however, diagnosis of Dengue fever should first be ruled out to avoid hemorrhage associated with the use of NSAIDs and aspirin when ill with dengue.…”

Section: Treatment and Managementmentioning

confidence: 99%

“…Consultation with an experienced obstetrics and gynecology specialist in conjunction with an infectious disease specialist is vital in the management of possible ZIKV infection [90]. Some of the care includes repeated ultrasonography for fetal evaluation, amniocentesis, postnatal management in the testing of placental tissues, and newborns should be tested and evaluated for congenital ZIKV infection following CDC guidelines [57,88]. Followup care of children born to mothers with probable exposure to ZIKV during pregnancy is critical for appropriate intervention [88].…”

Section: Treatment and Managementmentioning

confidence: 99%

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Zika Virus in Africa: Epidemiology and Determinants

Obore

Papabathini

Ghimire

et al. 2019

JAMMR

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Zika virus (ZIKV) that was less known for decades suddenly became a global health emergency at the beginning of 2016. The virus was first discovered in the Zika forest of Uganda in 1947, and the first confirmed human infection was reported in Uganda between1962-1963. From its origin in East Africa, ZIKV then spread to West and Central Africa with a limited occurrence in North Africa. ZIKV has been circulating in Africa for over 60 years, but less attention had been given, not until its recent outbreaks outside Africa and its discovered association with adverse congenital disabilities. ZIKV is known to cause several debilitating neurological complications, including microcephaly in newborns and Guillain-Barré Syndrome (GBS) in adults. This review thus aims to highlight the epidemiological evidence and distribution of ZIKV in Africa with a focus on determinants, complications as well as management. We used literature searched from key databases such as Google Scholar, Web of Science, among others, to collect relevant current information about ZIKV in Africa. Climate, sociodemographic factors, and increasing human density impact the spread of ZIKV in Africa, as in other areas. Furthermore, ZIKV transmission is affected by several unique factors, including the potential risk of sexual transmission, as well as vast numbers of refugees and other travellers from ZIKA endemic areas across Africa, and all over the world. The review identifies the need to improve surveillance mechanisms and focusing on vector control as critical steps to enable prompt detection and avert potential outbreaks of the disease in the continent.

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Section: Treatment and Managementmentioning

confidence: 99%

Section: Treatment and Managementmentioning

confidence: 99%

Zika Virus in Africa: Epidemiology and Determinants

Obore

Papabathini

Ghimire

et al. 2019

JAMMR

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“…Thus, differential signs and symptoms of each patient must be evaluated cautiously, as due to the similarity with other Flavivirus infections such as dengue and chikungunya, ZIKV infection may be misdiagnosed. A summarized list of differential diagnosis, laboratory tests and patient managing protocols have been elaborated [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Zika virus congenital syndrome: experimental models and clinical aspects

Polonio

Freitas

Zanluqui

et al. 2017

J Venom Anim Toxins Incl Trop Dis

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Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic and social cost. In this context, a recently introduced flavivirus in South America, called Zika virus (ZIKV), led the WHO to declare in February 1st 2016 a warning on Public Health Emergency of International Concern (PHEIC). ZIKV is an arbovirus of the Flaviviridae family firstly isolated from sentinels Rhesus sp. monkeys at the Ziika forest in Uganda, Africa, in 1947. Lately, the virus has well adapted to the worldwide spread Aedes aegypti mosquito, the vector for DENV, CHIKV, YFV and many others. At first, it was not considered a threat to human health, but everything changed when a skyrocketing number of babies born with microcephaly and adults with Guillain-Barré syndrome were reported, mainly in northeastern Brazil. It is now well established that the virus is responsible for the so called congenital Zika syndrome (CZS), whose most dramatic features are microcephaly, arthrogryposis and ocular damage. Thus, in this review, we provide a brief discussion of these main clinical aspects of the CZS, correlating them with the experimental animal models described so far.

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“…It can influence the nervous system and cause serious problems for human embryos (1)(2)(3)(4). ZIKV infection in pregnant women causes birth of newborns suffering from microcephaly.…”

mentioning

confidence: 99%