Lumican negatively controls the pathogenicity of murine encephalitic TH17 cells

Castillo, Eliseo F.; Zheng, Handong; Cabanlong, Christian Van; Dong, Fei; Luo, Yan; Yang, Yi; Liu, Meilian; Kao, Winston W.‐Y.; Yang, Xuexian O.

doi:10.1002/eji.201646507

Cited by 9 publications

(9 citation statements)

References 52 publications

(80 reference statements)

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“…LUM encodes a Lumican, an extracellular matrix protein that member of the small leucine-rich proteoglycan (SLRP) family. LUM has emerged as modulators of the inflammatory responses, which alters and impact cytokine expression [88]. OLFM4, is a strongly expressed glycoprotein in the intestine, participating in innate immunity and inflammation, and upregulated by gastrointestinal tract diseases [89].…”

Section: Discussionmentioning

confidence: 99%

Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs

et al. 2019

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The importance of probiotics in swine production is widely acknowledged as crucial. However, gaps still remain in the exact roles played by probiotics in modulation of gut microbiota and immune response. This study determined the roles of probiotic Lactobacillus plantarum strain JDFM LP11in gut microbiota modulation and immune response in weaned piglets. L. plantarum JDFM LP11 increased the population of lactic acid bacteria in feces and enhanced the development of villi in the small intestine. Metagenome analysis showed that microbial diversity and richness (Simpson, Shannon, ACE, Chao1) and the relative abundance of the Firmicutes were higher in weaned piglets fed probiotics. Five bacterial families were different in the relative abundance, especially; Prevotellaceae occupied the largest part of microbial community showed the most difference between two groups. Transcriptome analysis identified 25 differentially expressed genes using RNAsequencing data of the ileum. Further gene ontology and immune DB analysis determined 8 genes associated with innate defense response and cytokine production. BPI, RSAD2, SLPI, LUM, OLFM4, DMBT1 and C6 genes were down-regulated by probiotic supplementation except PLA2G2A. PICRUSt analysis predicting functional profiling of microbial communities indicated branched amino acid biosynthesis and butyrate metabolism promoting gut development and health were increased by probiotics. Altogether, our data suggest that L. plantarum JDFM LP11 increases the diversity and richness in the microbial community, and attenuates the ileal immune gene expression towards gut inflammation, promoting intestinal development in weaned piglets.

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Section: Discussionmentioning

confidence: 99%

Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs

et al. 2019

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“…Gene mRNA expression was determined by RT-qPCR as described previously 38 , 51 . Data were normalized to an Actb reference gene.…”

Section: Methodsmentioning

confidence: 99%

Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway

Zheng

et al. 2018

Sci Rep

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Allergic asthma and obesity are major public health problems in the world. Recent Meta-analysis studies implicated a positive relationship between serum leptin, which is elevated in obese individuals, and the risk of asthma. However, it is not well understood how obesity-associated elevation of leptin increases the risk of asthma. In the current study, we have found that leptin induces the unfolded protein response factor XBP1s in an mTOR- and MAPK-dependent manner in pro-allergic TH2 cells; in vivo, mice fed with high fat diet had increased serum leptin as observed in human obese population and exacerbated asthmatic symptoms, associated with increased XBP1s expression in splenic CD4+ T cells. XBP1s is required for leptin-mediated pro-allergic TH2 cell survival and cytokine production. Our results reveal a previously unappreciated insight that obesity-associated hyperleptinemia contributes to enhanced pro-allergic lymphocyte responses through induction of XBP1s, leading to exacerbation of allergic asthma.

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“…Furthermore, lumican regulates the progression of MS, 146 a chronic autoimmune disease of the central nervous system. 147 Accordingly, lumican-deficient mice displayed an earlier onset and enhanced disease severity in experimental autoimmune encephalomyelitis (EAE).…”

Section: Lumican-specific Regulation Of the Inflammatory Responsementioning

confidence: 99%

“… 147 Accordingly, lumican-deficient mice displayed an earlier onset and enhanced disease severity in experimental autoimmune encephalomyelitis (EAE). 146 Several studies have implicated that Th17 cells play an essential role in the development of both human MS and animal model EAE. 148 – 150 Mechanistically, lumican promotes apoptosis of Th17 cells via the Fas–FasL signaling pathway and inhibits the expression of pro-inflammatory IL-17, a Th17 cytokine.…”

Section: Lumican-specific Regulation Of the Inflammatory Responsementioning

confidence: 99%

“… 148 – 150 Mechanistically, lumican promotes apoptosis of Th17 cells via the Fas–FasL signaling pathway and inhibits the expression of pro-inflammatory IL-17, a Th17 cytokine. 146 Thus, lumican acts as an endogenous inhibitor of Th17 cells, negatively regulating Th17 cell–mediated inflammation in MS.…”

Section: Lumican-specific Regulation Of the Inflammatory Responsementioning

confidence: 99%

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Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

Zeng-Brouwers

Pandey

Trebicka

et al. 2020

J Histochem Cytochem.

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Inflammation is a highly regulated biological response of the immune system that is triggered by assaulting pathogens or endogenous alarmins. It is now well established that some soluble extracellular matrix constituents, such as small leucine-rich proteoglycans (SLRPs), can act as danger signals and trigger aseptic inflammation by interacting with innate immune receptors. SLRP inflammatory signaling cascade goes far beyond its canonical function. By choosing specific innate immune receptors, coreceptors, and adaptor molecules, SLRPs promote a switch between pro- and anti-inflammatory signaling, thereby determining disease resolution or chronification. Moreover, by orchestrating signaling through various receptors, SLRPs fine-tune inflammation and, despite their structural homology, regulate inflammatory processes in a molecule-specific manner. Hence, the overarching theme of this review is to highlight the molecular and functional specificity of biglycan-, decorin-, lumican-, and fibromodulin-mediated signaling in inflammatory and autoimmune diseases

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Lumican negatively controls the pathogenicity of murine encephalitic TH17 cells

Cited by 9 publications

References 52 publications

Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs

Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs

Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway

Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases

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