Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25‐hydroxyvitamin D in a pan‐European population: the Food4Me study

Livingstone, Katherine M.; Celis‐Morales, Carlos; Hoeller, Ulrich; Lambrinou, Christina P.; Moschonis, George; Macready, Anna L.; Fallaize, Rosalind; Baur, Manuela; Roos, Franz F.; Bendik, Igor; Grimaldi, Keith; Navas-Carretero, Santiago; San-Cristóbal, Rodrigo; Weber, Peter; Drevon, Christian A.; Μanios, Yannis; Traczyk, Iwona; Gibney, Eileen R.; Lovegrove, Julie A.; Daniel, Hannelore; Gibney, Mike; Martínez, J. Alfredo; Brennan, Lorraine; Hill, Tom R.; Mathers, John C.

doi:10.1002/mnfr.201600476

Cited by 11 publications

(12 citation statements)

References 43 publications

(62 reference statements)

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“…The equator proximity is a strong stimulus for VD synthesis, that is, efficiency in VD production is due to ultraviolet radiation availability [52]. Additionally, one study showed that the relationship between VDR genotype and VD concentration can be influenced by sunlight exposure [53]. Our results also showed that patients with higher VD concentrations present higher sunlight exposure/VD-rich diet than patients with low levels of VD concentrations (Figure 1, Tables 2-4).…”

Section: Discussionsupporting

confidence: 54%

“…In this context, we found that patients who stayed longer in the sun and consumed VD-rich foods frequently had lower levels of MDA and CG compared to patients who did not stay in the sun long enough and did not consume foods rich in VD regularly. These data, although not confirming the relationship between VD deficiency, lipid peroxidation, and protein oxidation, can be interpreted as A B an indication of such relationship, since sunlight directly affects VD 3 synthesis [50][51][52][53][54]. VD is also founded in foods, such as liver, fish, eggs, and milk.…”

Section: Discussionmentioning

confidence: 70%

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The relationship between vitamin D deficiency and oxidative stress can be independent of age and gender

Câmara

Brandão

2021

International Journal for Vitamin and Nutrition Research

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Abstract. The active vitamin D (1,25(OH)2D) acts through a nuclear receptor to perform several functions in cellular metabolism. 1,25(OH)2D participates directly in calcium homeostasis, regulates the immune system, nervous system, blood pressure, insulin secretion, among others. Vitamin D deficiency could also be associated with several diseases and increased cellular oxidative damage. The present study aimed to investigate whether lipid peroxidation and/or protein oxidation are affected by vitamin D deficiency and whether sunlight exposure/diet, gender, and age might influence this relationship. Vitamin D concentrations were obtained from the Heart Hospital database and a questionnaire was applied among the 212 participants. We used the inactive vitamin D (25(OH)2) in the analyses since 1,25(OH)2D has a short half-life and a low blood concentration. Lipid peroxidation and protein oxidation analyses were performed using spectrophotometry. Multivariate analyses suggested the participation of vitamin D deficiency (<30 ng/mL) and sunlight/diet in oxidative stress (p <0.05; R2 MDA: 0.562; R2 CG: 0.429). Multiple linear regression test show that the age and gender of patients are not interfering in the analyses (p>0.05). Therefore, we suggest that the relationship between vitamin D deficiency and oxidative stress can be independent of age and gender.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 70%

The relationship between vitamin D deficiency and oxidative stress can be independent of age and gender

Câmara

Brandão

2021

International Journal for Vitamin and Nutrition Research

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“…While the etiology of asthma is still not fully understood, it is believed to be closely associated with genetic and environmental factors (such as inhalation of mites, dust, drugs, and other allergens). It can also be related to factors such as air pollution, smoking, respiratory virus infection, strenuous exercise, inhalation of copious amounts of cold air, and allergic physique of the mother during the fetal period (5). The current global research data on asthma susceptibility shows that there are more than one hundred known asthma-related genes.…”

Section: Original Articlementioning

confidence: 99%

The association between vitamin D receptor gene polymorphisms and asthma: a systematic review and meta-analysis

He¹,

Zhou²,

Han³

et al. 2022

Ann Palliat Med

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Background: Numerous studies have reported on the genetic factors related to asthma. In recent years, the vitamin D receptor (VDR) has been identified as one of the asthma susceptibility genes that is closely associated with the pathogenesis of asthma.Methods: Randomized controlled trials (RCTs) related to asthma and the VDR were identified from the Chinese and English databases. The following keywords were used as search terms: "asthma", "vitamin D receptor", "VDR", "polymorphism", and "mutation". Meta-analysis was performed using RevMan 5.3 and Stata 13 software provided by the Cochrane system.Results: A total of 7 RCTs were included in this meta-analysis, 6 of which described the correct random allocation methods, 6 described the allocation plan in detail, and 4 used the blinding method. The frequency of the CC + CA dominant genotype at the Apa I locus and the GG + GA genotype frequency at the Bsm I locus of the VDR gene were significantly higher in asthmatic patients compared to control healthy patients [odds ratio (OR) =0.81, 95% confidence interval (CI): 0.68 to 0.98, P=0.03<0.05; and OR =2.05, 95% CI:1.23 to 3.41, P=0.006<0.05, respectively]. There were no significant differences between the CC, CT, and TT genotype frequencies at the Fok I site of the VDR gene in the experimental group and the CC, CT, TT genotype frequencies at the Taq I site and the control group (P>0.05). There was no significant difference between the genotype frequencies.Discussion: Meta-analysis confirmed that VDR gene polymorphisms are closely related to the onset of asthma, and the gene expression of the Fok I, Bsm I, Apa I, and Taq I loci directly affects the incidence of asthma.

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“…Vitamin D, as an important nutrient in the body, acts a pivotal part in regulating Ca and P homeostasis, maintaining growth and development of bone (Plum & Deluca, 2010). It is stated that age, sex, dietary vitamin D intake and sunlight exposure were associated with circulating 25(OH)D 3 concentration (Livingstone et al, 2017). Vitamin D is mainly produced in the skin or ingested from the diet (Holick, 2011).…”

mentioning

confidence: 99%

Effects of 25(OH)D₃ supplementation during late gestation on the serum biochemistry and reproductive performance of aged sows and newborn piglets

Huang

Deng

Yang

et al. 2021

Animal Physiology Nutrition

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Calcium (Ca) and phosphorus (P) are essential mineral elements in pigs, which play an important role in bone development, energy utilization and signal transduction. Inadequate or inappropriate ratio of Ca to P in diets may affect the normal growth and development of pigs (Gonzalo et al., 2018). Vitamin D, as an important nutrient in the body, acts a pivotal part in regulating Ca and P homeostasis, maintaining growth and development of bone (Plum & Deluca, 2010). It is stated that age, sex, dietary vitamin D intake and sunlight exposure were associated with circulating 25(OH)D 3 concentration (Livingstone et al., 2017). Vitamin D is mainly produced in the skin or ingested from the diet (Holick, 2011). At ultraviolet B-type (UVB) exposure, vitamin D synthesis occurs in the skin and is affected by the duration and the intensity of the light (Judistiani et al., 2019). Vitamin D supplementation is more effective than sunlight exposure in increasing circulating

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Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25‐hydroxyvitamin D in a pan‐European population: the Food4Me study

Cited by 11 publications

References 43 publications

The relationship between vitamin D deficiency and oxidative stress can be independent of age and gender

The relationship between vitamin D deficiency and oxidative stress can be independent of age and gender

The association between vitamin D receptor gene polymorphisms and asthma: a systematic review and meta-analysis

Effects of 25(OH)D₃ supplementation during late gestation on the serum biochemistry and reproductive performance of aged sows and newborn piglets

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Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25‐hydroxyvitamin D in a pan‐European population: the Food4Me study

Cited by 11 publications

References 43 publications

The relationship between vitamin D deficiency and oxidative stress can be independent of age and gender

The relationship between vitamin D deficiency and oxidative stress can be independent of age and gender

The association between vitamin D receptor gene polymorphisms and asthma: a systematic review and meta-analysis

Effects of 25(OH)D3 supplementation during late gestation on the serum biochemistry and reproductive performance of aged sows and newborn piglets

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Effects of 25(OH)D₃ supplementation during late gestation on the serum biochemistry and reproductive performance of aged sows and newborn piglets