Ten-year outcome of early childhood traumatic brain injury: Diffusion tensor imaging of the ventral striatum in relation to executive functioning

Faber, Jessica; Wilde, Elisabeth A.; Hanten, Gerri; Ewing‐Cobbs, Linda; Aitken, Mary E.; Yallampalli, Ragini; MacLeod, Marianne; Mullins, Samantha H.; Chu, Zili; Li, X.; Hunter, Jill V.; Noble-Haeusslein, Linda J.; Levin, Harvey S.

doi:10.1080/02699052.2016.1199910

Cited by 22 publications

(27 citation statements)

References 34 publications

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“…For instance, survivors of childhood TBI with inhibition deficits demonstrate difficulties regulating appropriate behavioral responses (Beauchamp & Anderson, 2010). At present, childhood TBI research has demonstrated the persistence of EF deficits up to 10 years post injury (Faber et al, 2016;Muscara et al, 2008). The present study furthers the research on childhood TBI by demonstrating the very long-term impact of 16-year childhood TBI on EF abilities.…”

Section: Discussionmentioning

confidence: 56%

“…Most recently, reduced white matter integrity of the frontal lobes, particularly the ventral striatum, has been linked to impaired EF in long-term childhood TBI survivors (Faber et al, 2016;Zappala et al, 2012). Indeed, the frontal lobes rest against the rough interior of the skull, rendering it more susceptible to damage following an injury to the head (Bigler, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Although previous reports establish a link between persisting impairments in inhibition, cognitive flexibility, and white matter volume reductions in pediatric TBI (Faber et al, 2016;Kurowski et al, 2009), the neural correlates of long-term outcomes in this domain are poorly characterized. For instance, no study to date has investigated the possible link between white matter volume and inhibition and cognitive flexibility in the long-term post childhood TBI.…”

Section: Significancementioning

confidence: 99%

“…According to a recent systematic review, EF abilities differed across severity groups, and moderate childhood TBI survivors have been found to be more likely to display EF-related difficulties at follow-up compared with mild childhood TBI survivors (Lloyd, Wilson, Tenovuo, & Saarijärvi, 2015). Of note, EF deficits have been most apparent in past studies that compared across severity subgroups (Nadebaum, Anderson, & Catroppa, 2007;TrebleBarna et al, 2016) and between moderate-to-severe childhood TBI survivors and typically developing peers (Cooper et al, 2014;Faber et al, 2016;Levin et al, 2004;Muscara et al, 2008). Taken together, it is possible that EF deficits, if any, following from more severe childhood TBI, may have been concealed in the present study.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

“…To disentangle higherorder EF (i.e., inhibition and cognitive flexibility abilities) from basic processing skills (e.g., color naming), contrast measures were derived based on performance on the CWIT in the present study (Delis et al, 2001). In contrast, Faber et al (2016) and Muscara et al (2008) operationalized inhibition and cognitive flexibility abilities by taking completion time and total number of errors on the CWIT inhibition and inhibition/switching tasks. Of note, there were suggestions that EF deficits in childhood TBI survivors may be confounded by impaired processing speed (Ginstfeldt & Emanuelson, 2010;K€ onigs et al, 2015).…”

Section: Predictors Of Ef Performance At 16-year Follow-upmentioning

confidence: 99%

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Brain volumetric correlates of inhibition and cognitive flexibility 16 years following childhood traumatic brain injury

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Reyes

et al. 2017

J of Neuroscience Research

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Executive functions (EFs), such as inhibition and cognitive flexibility, are essential for everyday functioning, including regulation of socially appropriate emotional responses. These skills develop during childhood and continue maturing into early adulthood. The current study aimed to investigate the very long-term impact of childhood traumatic brain injury (TBI) on inhibition and cognitive flexibility, and to examine whether global white matter is associated with these abilities. Inhibition, the ability to monitor and control responses, and cognitive flexibility, the ability to switch attention between cognitive demands (Konrad, Gauggel, Manz, & Sch€ oll, 2000), are EF skills particularly vulnerable to childhood TBI (Anderson et al., 2001). Impairments in these domains have been associated with difficulties in everyday functioning, such as regulating socially appropriate emotional and behavioral responses (Beauchamp & Anderson, 2010;Ganesalingam, Yeates, Sanson, & Anderson, 2007;Gioia, Isquith, Guy, & Kenworthy, 2000). SignificanceThis study highlights the enduring impact that childhood traumatic brain injury can exert on survivors throughout late adolescence and into early adulthood. Survivors who sustained traumatic brain injury in childhood did not reflect the typical brain behavior relationship that characterized executive function in adulthood. These findings suggest long-lasting changes in the brain behavior connections following childhood traumatic brain injury, thereby serving as a reminder to refrain from downplaying a head injury sustained in early childhood.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Significancementioning

confidence: 99%

Section: Limitations and Future Directionsmentioning

confidence: 99%

Section: Predictors Of Ef Performance At 16-year Follow-upmentioning

confidence: 99%

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Brain volumetric correlates of inhibition and cognitive flexibility 16 years following childhood traumatic brain injury

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Reyes

et al. 2017

J of Neuroscience Research

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Trajectories of Children's Executive Function After Traumatic Brain Injury

et al. 2021

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Key Points Question What is the 3-year trajectory of recovery of executive function after mild-to-severe traumatic brain injury in children? Findings In this longitudinal cohort study of 559 children with mild, moderate, or severe traumatic brain injury or orthopedic injury, patterns of recovery differed by injury severity, age at injury, and executive function assessed. Overall, growth curve models showed children’s functioning worsening most sharply from baseline to 12 months; children with severe traumatic brain injury showed a secondary worsening between 24 and 36 months on some subscales. Meaning Results suggest that changes in the recovery of children’s executive function over time will require repeated assessments in order to tailor interventions.

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Diffusion MRI in pediatric brain injury

Dennis

Babikian²,

Giza

et al. 2017

Childs Nerv Syst

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Traumatic brain injury (TBI) is a major public health issue around the world and can be especially devastating in children as TBI can derail cognitive and social development. White matter (WM) is particularly vulnerable to disruption post-TBI, as myelination is ongoing during this period. Diffusion magnetic resonance imaging (dMRI) is a versatile modality for identifying and quantifying WM disruption and can detect diffuse axonal injury (DAI or TAI (traumatic axonal injury)). This review covers dMRI studies of pediatric TBI, including mild to severe injuries, and covering all periods post-injury. While there have been considerable advances in our understanding of pediatric TBI through the use of dMRI, there are still large gaps in our knowledge, which will be filled in by larger studies and more longitudinal studies. Heterogeneity post-injury is an obstacle in all TBI studies, but we expect that larger better-characterized samples will aid in identifying clinically meaningful subgroups within the pediatric TBI patient population.

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Ten-year outcome of early childhood traumatic brain injury: Diffusion tensor imaging of the ventral striatum in relation to executive functioning

Cited by 22 publications

References 34 publications

Brain volumetric correlates of inhibition and cognitive flexibility 16 years following childhood traumatic brain injury

Brain volumetric correlates of inhibition and cognitive flexibility 16 years following childhood traumatic brain injury

Trajectories of Children's Executive Function After Traumatic Brain Injury

Diffusion MRI in pediatric brain injury

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