Low Vitamin D Level on Admission for Burn Injury Is Associated With Increased Length of Stay

Abstract

Currently, there have been few studies that have evaluated the incidence of vitamin D deficiency in adult burn patients or correlated vitamin D levels with burn-related outcomes. The primary objective of the study was to identify the incidence of vitamin D deficiency and insufficiency in an adult burn population. The secondary objective was to determine the impact of vitamin D deficiency and insufficiency on clinical outcomes in burn care. A single-center, retrospective, and observational cohort analysis of adult patients admitted for initial management of burn injury, who had a 25-hydroxyvitamin D (25D) level measured on admission, was performed. Patients were categorized as vitamin D deficient (25D <10 ng/ml), insufficient (10-29 ng/ml), or sufficient (30-100 ng/ml) based on admission measurements. Clinical outcomes including complications, intensive care unit (ICU) and hospital length of stay (LOS), and survival were compared between patients with vitamin D deficiency/insufficiency and patients with vitamin D sufficiency. Three-hundred and eighteen patients were eligible for evaluation. Admission 25D level correlated with deficiency in 46 patients (14.5%), insufficiency in 207 (65.1%), and normal in 65 (20.4%). Patients with vitamin D deficiency or insufficiency experienced higher rates of complications and longer ICU and hospital LOS compared with those with normal vitamin D levels. A large proportion of patients with burn injury presented with vitamin D insufficiency and deficiency which was associated with poor outcomes, including prolonged ICU and hospital LOS. Additional studies are needed to further describe the relationship between vitamin D status and clinical outcomes.

Long-Term Effects of Severe Burn Injury on Bone Turnover and Microarchitecture

“…Recent research on the supplementation of vitamin D in pediatric and adult burn patients has suggested positive impacts on the length of hospital stay or muscle strength but no effect on adult bone metabolism or aBMD …”

Витамин D И Ожоговая Травма

“…Исследование B. Blay et al показало более длительное пребывание в стационаре и в ОРИТ, более высокую частоту осложнений (сепсис, пневмония, сердечнососудистые осложнения, неприживление трансплантатов) у ожоговых пациентов с низким содержанием витамина D. Необходимо отметить, что низкие уровни Науковий огляд / Scientific Review витамина D были у пациентов до травмы, а не вследствие ожога: 79,6 % пациентов, участвовавших в исследовании, при поступлении в стационар имели уровень витамина D в крови ниже нормы [30].…”

Prevalence and clinical impact of vitamin D deficiency in critically ill Korean patients with traumatic injuries: a single-center, prospective, observational study

“…Most patients (182/191, 95.3%) were hospitalized after blunt trauma injury. These patients had a mean GCS score of 12.3±4.0 (range, [3][4][5][6][7][8][9][10][11][12][13][14][15], an ISS of 17.4±9.0 (range, 1-75), APACHE II score of 10.7±7.3, SOFA score of 3.3±3.1, and SAPS III of 45.2±15.7.…”