“…GABA is the important inhibitory neurotransmitter, and glutamate is the metabolic precursor of GABA, which can be recycled through the tricarboxylic acid cycle to synthesize glutamate. It has long been demonstrated that direct or indirect interference with GABA-mediated neurotransmission could induce convulsive seizure activity in humans and experimental animals( Gale, 1992 , Sousa et al, 2017 ), and seizure could be under control by the precisely tuned GABA delivery at the seizure onset( Slezia et al, 2019 ). ( Sousa et al, 2017 )( Ben-Menachem, 2011 )( Ben-Menachem, 2011 )( Sills and Rogawski, 2020 )( Lux et al, 2005 , O'Callaghan et al, 2017 )( Yang et al, 2012 )( Schwarz et al, 2016 ).…”