Neurobehavioral effects of vigabatrin and its ability to induce DNA damage in brain cells after acute treatment in rats

Abstract

VGB did not affect STM and LTM, but the drug impaired the exploration and locomotion likely associated with its sedative effect. In addition, no DNA damage in cortex and hippocampus was detected after behavioral testing, when brain GABA levels are already increased.

The Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis

“…Whether this result is related to the severity of the neuron loss in both groups, as we mentioned earlier, or to the ratio of normal versus abnormal/epileptic neurons remains to be determined. A recent study has shown that VGB, with the aid of inhibitory avoidance and open-field tasks, did not affect short-term memory or long-term memory, but it impaired exploration and locomotion performance [43], probably as a result of its sedative effect. Whether this effect contributed to the lack of difference in inhibitory avoidance behavior in our study remains to be determined in future studies.…”

Pharmacokinetics and tissue distribution of vigabatrin enantiomers in rats

“…GABA is the important inhibitory neurotransmitter, and glutamate is the metabolic precursor of GABA, which can be recycled through the tricarboxylic acid cycle to synthesize glutamate. It has long been demonstrated that direct or indirect interference with GABA-mediated neurotransmission could induce convulsive seizure activity in humans and experimental animals( Gale, 1992 , Sousa et al, 2017 ), and seizure could be under control by the precisely tuned GABA delivery at the seizure onset( Slezia et al, 2019 ). ( Sousa et al, 2017 )( Ben-Menachem, 2011 )( Ben-Menachem, 2011 )( Sills and Rogawski, 2020 )( Lux et al, 2005 , O'Callaghan et al, 2017 )( Yang et al, 2012 )( Schwarz et al, 2016 ).…”