Human–Animal Interface: The Case for Influenza Interspecies Transmission

Donatelli, Isabella; Castrucci, Maria Rita; Marco, Maria Alessandra De; Delogu, Mauro; Webster, Robert G.

doi:10.1007/5584_2016_136

Cited by 28 publications

(26 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transmission from domestic poultry directly to humans has been shown to occur and has been linked with the use of live poultry markets in southeast Asia [ 157 ]. Swine hosts frequently play a role in interspecies transmission both as the recipient host of transmitted avian and human viruses and the donor for a human transmission event (reviewed in [ 116 ]). Swine are also implicated in reverse zoonosis, as human viruses jump to swine and circulate within the swine host before potentially returning to humans [ 117 , 134 ].…”

Section: Interspecies Transmissionmentioning

confidence: 99%

The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase

Byrd-Leotis

Cummings

Steinhauer

2017

IJMS

169

140

View full text Add to dashboard Cite

The hemagglutinin (HA) and neuraminidase (NA) glycoproteins of influenza A virus are responsible for the surface interactions of the virion with the host. Entry of the virus is mediated by functions of the HA: binding to cellular receptors and facilitating fusion of the virion membrane with the endosomal membrane. The HA structure contains receptor binding sites in the globular membrane distal head domains of the trimer, and the fusion machinery resides in the stem region. These sites have specific characteristics associated with subtype and host, and the differences often define species barriers. For example, avian viruses preferentially recognize α2,3-Sialic acid terminating glycans as receptors and mammalian viruses recognize α2,6-Sialic acid. The neuraminidase, or the receptor-destroying protein, cleaves the sialic acid from cellular membrane constituents and viral glycoproteins allowing for egress of nascent virions. A functional balance of activity has been demonstrated between the two glycoproteins, resulting in an optimum level of HA affinity and NA enzymatic cleavage to allow for productive infection. As more is understood about both HA and NA, the relevance for functional balance between HA and NA continues to expand, with potential implications for interspecies transmission, host adaptation, and pathogenicity.

show abstract

Section: Interspecies Transmissionmentioning

confidence: 99%

The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase

Byrd-Leotis

Cummings

Steinhauer

2017

IJMS

169

140

View full text Add to dashboard Cite

show abstract

“…It is thought to occur when two or more of these distinct viruses infect a common host and generate novel virus subtypes or strains (11,12). Thus, antigenic shifts (principally underlying influenza A virus pandemics) and antigenic drifts (underlying vaccine mismatches against seasonal influenza A and B viruses) and wide host-range (for influenza A viruses) are responsible for the recurring cases of influenza all year round (13,14). Furthermore, antigenic drifts and shifts are particularly reasons for which there is an immediate need for highly efficacious intervention.…”

Section: Studies By Fergusson Et Al Revealed That Antigenic Drifts Inmentioning

confidence: 99%

Influenza Management Prospects of Passive Immunotherapy

Kotey¹,

Lukosaityte²,

Quaye³

et al. 2019

Preprint

View full text Add to dashboard Cite

Influenza is a disease that poses a significant health burden worldwide. Vaccination is the best way to prevent influenza virus infections. However, conventional vaccines are only effective for a short period of time due to the propensity of influenza viruses to undergo antigenic drift and antigenic shift. The efficacy of these vaccines is uncertain from year-to-year due to potential mismatching between the circulating viruses and vaccine strains, mutations arising due to egg adaptation, and potential contamination of the vaccine virus stock. Subsequently, the inability to store these vaccines long-term and vaccine shortages are challenges that need to be overcome. Conventional vaccines are also less effective for certain populations, including the young, old, and immunocompromised. This warrants for diverse efficacious vaccine developmental approaches, involving both active and passive immunization. As opposed to active immunization platforms (requiring the use of whole or portions of pathogens as vaccines), the rapidly developing passive immunization involves administration of either pathogen-specific or broadly acting antibodies against a kind or class of pathogens as a prophylactic treatment to corresponding acute infection. Several antibodies with broadly acting capacities have been discovered that may serve as means to suppress influenza viral infection and allow the process of natural immunity to engage opsonized pathogens whilst boosting immune system by antibody-dependent mechanisms that bridge the innate and adaptive arms. By that, passive immunotherapeutics approach assumes a robust tool that could aid control of influenza viruses. In this review, we comment on some improvements in influenza management and promising vaccine development platforms, with emphasis on the capacity of passive immunotherapeutics especially when coupled with the use of antivirals in the management of influenza infection.

show abstract

“…as well as the ongoing highly lethal zoonotic infections with avian H5N1 and H7N9 subtype strains remain a constant threat for the human population (2). Human influenza virus was first isolated more than 80 years ago (3).…”

mentioning

confidence: 99%

Quantitative Proteomic Approach Identifies Vpr Binding Protein as Novel Host Factor Supporting Influenza A Virus Infections in Human Cells

Sadewasser

Paki

Eichelbaum

et al. 2017

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

Influenza A virus (IAV) infections are a major cause for respiratory disease in humans, which affects all age groups and contributes substantially to global morbidity and mortality. IAV have a large natural host reservoir in avian species. However, many avian IAV strains lack adaptation to other hosts and hardly propagate in humans. While seasonal or pandemic IAV strains replicate efficiently in permissive human cells, many avian IAV cause abortive nonproductive infections in these hosts despite successful cell entry. However, the precise reasons for these differential outcomes are poorly defined. We hypothesized that the distinct course of an IAV infection with a given virus strain is determined by the differential interplay between specific host and viral factors. By using Spike-in SILAC mass spectrometry-based quantitative proteomics we characterized sets of cellular factors whose abundance is specifically

show abstract

Human–Animal Interface: The Case for Influenza Interspecies Transmission

Cited by 28 publications

References 113 publications

The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase

The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase

Influenza Management Prospects of Passive Immunotherapy

Quantitative Proteomic Approach Identifies Vpr Binding Protein as Novel Host Factor Supporting Influenza A Virus Infections in Human Cells

Contact Info

Product

Resources

About