Vitamin D in newborns. A randomised controlled trial comparing daily and single oral bolus vitamin D in infants

Huynh, Julie; Lu, Thao; Liew, Danny; Doery, James C.G.; Tudball, Ronald; Jona, Madeleine; Bhamjee, Roisin; Rodda, Christine

doi:10.1111/jpc.13338

Cited by 36 publications

(52 citation statements)

References 25 publications

(45 reference statements)

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“…Public education on the risks associated with severe vitamin D deficiency, including rickets, may improve uptake in the general population. Additional potential strategies to simplify regimens and increase adherence with supplementation may include the use of higher dose weekly or monthly vitamin D regimens rather than daily supplementation; incorporation of high‐dose, intermittent vitamin D supplements into childhood primary healthcare programs or routine immunization visits (see below); and supplementation of lactating mothers with high‐dose vitamin D instead of direct infant supplementation…”

Section: Interventions To Reduce the Prevalence Of Vitamin D Deficienmentioning

confidence: 99%

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries

Roth

Abrams

Aloia

et al. 2018

Annals of the New York Academy of Sciences

397

340

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Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many countries have a relatively low supply of foods rich in vitamin D and inadequate exposure to natural ultraviolet B (UVB) radiation from sunlight, an important proportion of the global population is at risk of vitamin D deficiency. There is general agreement that the minimum serum/plasma 25-hydroxyvitamin D concentration (25(OH)D) that protects against vitamin D deficiency-related bone disease is approximately 30 nmol/L; therefore, this threshold is suitable to define vitamin D deficiency in population surveys. However, efforts to assess the vitamin D status of populations in low- and middle-income countries have been hampered by limited availability of population-representative 25(OH)D data, particularly among population subgroups most vulnerable to the skeletal and potential extraskeletal consequences of low vitamin D status, namely exclusively breastfed infants, children, adolescents, pregnant and lactating women, and the elderly. In the absence of 25(OH)D data, identification of communities that would benefit from public health interventions to improve vitamin D status may require proxy indicators of the population risk of vitamin D deficiency, such as the prevalence of rickets or metrics of usual UVB exposure. If a high prevalence of vitamin D deficiency is identified (>20% prevalence of 25(OH)D < 30 nmol/L) or the risk for vitamin D deficiency is determined to be high based on proxy indicators (e.g., prevalence of rickets >1%), food fortification and/or targeted vitamin D supplementation policies can be implemented to reduce the burden of vitamin D deficiency-related conditions in vulnerable populations.

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Section: Interventions To Reduce the Prevalence Of Vitamin D Deficienmentioning

confidence: 99%

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐ and middle‐income countries

Roth

Abrams

Aloia

et al. 2018

Annals of the New York Academy of Sciences

397

340

View full text Add to dashboard Cite

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“…The suggested treatment is generally 400 IU cholecalciferol daily. 4 Less commonly Stoss therapy with 50 000 IU cholecalciferol followed by 400 IU daily after 3 months is recommended, 4 although we have seen drug errors associated with the use of the Stoss protocol in neonates. Unfortunately, there was major inconsistency across the protocols in process for identification of infants requiring preventive vitamin D treatment, and of who is responsible for arranging treatment.…”

mentioning

confidence: 99%

Prophylactic Vitamin D Supplementation in High‐Risk Breastfed Infants

Pinto

Bergman

Brown

et al. 2017

J Paediatrics Child Health

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Vitamin D deficiency in children is associated with decreased bone mineralisation, deformational rickets and, in severe cases, hypocalcaemic seizure, motor delay and cardiomyopathy.1 Infant vitamin D status at birth is a reflection of maternal stores, and deficiency less than 50 nmol/L occurs in a striking 11% of all infants in Australia, and in 72% of infants whose mothers have dark skin. 2 Breastfed infants are at higher risk of deficiency, as, despite its benefits, breastmilk contains insufficient vitamin D for infant requirements. Most Australian formulas contain vitamin D supplementation.

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“…

We read with great interest the article by Huynh et al 1 titled 'Vitamin D in newborns. A randomised controlled trial comparing daily and single oral bolus vitamin D in infants' published in your journal which concluded that a single bolus dose of cholecalciferol is a safe and effective alternative to daily vitamin D dosing for healthy breastfed newborn infants of vitamin D deficient mothers.

…”

mentioning

confidence: 99%