Effects of different surface modifying agents on the cytotoxic and antimicrobial properties of ZnO nanoparticles

Esparza‐González, Sandra Cecilia; Sánchez-Valdés, S.; Ramirez-Barron, Sonia Nohemi; Loera‐Arias, María de Jesús; Bernal, Javier Galbán; Meléndez‐Ortiz, H. Iván; Betancourt-Galindo, R.

doi:10.1016/j.tiv.2016.09.020

Cited by 63 publications

(19 citation statements)

References 24 publications

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“…Cell viability is dose‐dependent; pure and APTES‐decorated ZnO exhibit low cytotoxicity while dimethyl sulfoxide (DMSO)‐functionalized ZnO NPs are toxic even at a low nanoparticle concentration. [ 356 ] The final toxicity reflects the physicochemical modifications achieved by the coating, such as changes in particle aggregation state, dissolution, zeta potential and the release of ions and free radicals to a solution. Another method for reducing the toxicity of metal/metal oxide NPs is doping with other metal ions.…”

Section: Perspectivesmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

473

368

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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Section: Perspectivesmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

473

368

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“…Zinc oxide is described as a versatile inorganic material with a broad range of applications. In the form of nanoparticles (nZnO), it has antimicrobial activity against both Gram-positive (G+) and Gramnegative (G-) bacteria [26,27]. The exact mechanism of the antimicrobial activity of ZnO continues to attract the interest of researchers.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Those ions have a significant effect in the active transport inhibition as well as in the amino acid metabolism and enzymes system disruption [28]. In general the antibacterial properties of nanomaterials are enhanced by their high specific surface to volume ratio [27,28].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Electrophoretic deposition of organic/inorganic composite coatings containing ZnO nanoparticles exhibiting antibacterial properties

Karbowniczek

Cordero-Arias

Virtanen

et al. 2017

Materials Science and Engineering: C

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To address one of the serious problems associated with permanent implants, namely bacterial infections, novel organic/inorganic coatings containing zinc oxide nanoparticles (nZnO) are proposed. Coatings were obtained by electrophoretic deposition (EPD) on stainless steel 316L. Different deposition conditions namely: deposition times in the range 60-300s and applied voltage in the range 5-30V as well as developing a layered coating approach were studied. Antibacterial tests against gram-positive Staphylococcus aureus and gram-negative Salmonella enteric bacteria confirmed the activity of nZnO to prevent bacterial growth. Coatings composition and morphology were analyzed by thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscopy and energy dispersive X-ray spectroscopy. Moreover, the corrosion resistance was analyzed by evaluation of the polarization curves in DMEM at 37°C, and it was found that coatings containing nZnO increased the corrosion resistance compared to the bare substrate. Considering all results, the newly developed coatings represent a suitable alternative for the surface modification of metallic implants.

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“…ZnO NPs increased interferon gamma, TNF-α and IL-12 expression in primary human immune cells, 88 while in another study, IL-6, IL-1β, IL-8 and TNF-α were induced by ZnO NPs from peripheral blood mononuclear cells. 53 TiO 2 89 and SiO 2 NPs 90 activated inflammasomes and induced IL-1β release, which affected fibroblast proliferation. Ag NPs also induced inflammasome formation and triggered IL-1β release and subsequent caspase-1 activation.…”

mentioning

confidence: 99%

Nanomaterials for alternative antibacterial therapy

Hemeg

2017

IJN

420

262

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Despite an array of cogent antibiotics, bacterial infections, notably those produced by nosocomial pathogens, still remain a leading factor of morbidity and mortality around the globe. They target the severely ill, hospitalized and immunocompromised patients with incapacitated immune system, who are prone to infections. The choice of antimicrobial therapy is largely empirical and not devoid of toxicity, hypersensitivity, teratogenicity and/or mutagenicity. The emergence of multidrug-resistant bacteria further intensifies the clinical predicament as it directly impacts public health due to diminished potency of current antibiotics. In addition, there is an escalating concern with respect to biofilm-associated infections that are refractory to the presently available antimicrobial armory, leaving almost no therapeutic option. Hence, there is a dire need to develop alternate antibacterial agents. The past decade has witnessed a substantial upsurge in the global use of nanomedicines as innovative tools for combating the high rates of antimicrobial resistance. Antibacterial activity of metal and metal oxide nanoparticles (NPs) has been extensively reported. The microbes are eliminated either by microbicidal effects of the NPs, such as release of free metal ions culminating in cell membrane damage, DNA interactions or free radical generation, or by microbiostatic effects coupled with killing potentiated by the host’s immune system. This review encompasses the magnitude of multidrug resistance in nosocomial infections, bacterial evasion of the host immune system, mechanisms used by bacteria to develop drug resistance and the use of nanomaterials based on metals to overcome these challenges. The diverse annihilative effects of conventional and biogenic metal NPs for antibacterial activity are also discussed. The use of polymer-based nanomaterials and nanocomposites, alone or functionalized with ligands, antibodies or antibiotics, as alternative antimicrobial agents for treating severe bacterial infections is also discussed. Combinatorial therapy with metallic NPs, as adjunct to the existing antibiotics, may aid to restrain the mounting menace of bacterial resistance and nosocomial threat.

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Effects of different surface modifying agents on the cytotoxic and antimicrobial properties of ZnO nanoparticles

Cited by 63 publications

References 24 publications

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Electrophoretic deposition of organic/inorganic composite coatings containing ZnO nanoparticles exhibiting antibacterial properties

Nanomaterials for alternative antibacterial therapy

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