2017
DOI: 10.1016/j.micinf.2016.09.005
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A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

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Cited by 8 publications
(6 citation statements)
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“…However, the massively increased p24 levels in the culture supernatant clearly indicate that the virus is being released well from BAGN-treated cells and that the higher MFI may reflect an increased replication and burst size of infected cells. Interestingly, a recent report showed that TIM-1 variants with a 6-amino acid shorter mucin domain were related with delayed HIV progression and a recent study, using our own cohorts, indicates that losing the mucin domain on TIM-1 is associated with relative protection from HIV infection ( 54 , 55 ). Alternatively, HIV infectivity and cell susceptibility for infection could be increased by more generalizable mechanisms that may affect other viruses as well, including the reduction of the mucin layer associated with membrane glycoproteins, which would increase fusogenicity of the virus or the exposure of the receptors needed for viral infection.…”
Section: Discussionmentioning
confidence: 85%
“…However, the massively increased p24 levels in the culture supernatant clearly indicate that the virus is being released well from BAGN-treated cells and that the higher MFI may reflect an increased replication and burst size of infected cells. Interestingly, a recent report showed that TIM-1 variants with a 6-amino acid shorter mucin domain were related with delayed HIV progression and a recent study, using our own cohorts, indicates that losing the mucin domain on TIM-1 is associated with relative protection from HIV infection ( 54 , 55 ). Alternatively, HIV infectivity and cell susceptibility for infection could be increased by more generalizable mechanisms that may affect other viruses as well, including the reduction of the mucin layer associated with membrane glycoproteins, which would increase fusogenicity of the virus or the exposure of the receptors needed for viral infection.…”
Section: Discussionmentioning
confidence: 85%
“…TIM-1-364aa overexpression significantly promoted the entry and infection of Japanese encephalitis virus compared with the short form of TIM-1 ( 25 ). In human immunodeficiency virus, homozygosity for the short allele of TIM-1 was associated with natural protection from infection and a lower rate of virus replication in CD4 + T lymphocytes ( 28 ). Additionally, TIM-1-364aa was associated with more severe outcome of infection with hepatitis A virus ( 26 , 27 ).…”
Section: Discussionmentioning
confidence: 99%
“…Also, a TIM-1 protein containing the 157insMTTTVP insertion bound to HAV more efficiently in binding assays and affected virus uncoating. Moreover, the 6-amino acid deletion provides protection against HIV-1 infection in clinical trials [ 21 , 32 , 33 ]. A 5-amino acid insertion (157ins MTTVP) in TIM-1 made cells more susceptible to viruses than a 6-amino acid 157ins MTTTVP [ 15 ].…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have reported that the 6-amino acid insertion (157ins MTTTVP) was associated with several severe diseases [ 31 ]. Polymorphisms of TIM-1 are associated with cell susceptibility to infection by several viruses, including HIV and HAV [ 21 , 32 , 33 ]. However, the role of TIM-1 in JEV infection and if TIM-1 polymorphisms are involved in cells susceptibility to JEV is still unknown.…”
Section: Introductionmentioning
confidence: 99%