The cortical surface correlates of clinical manifestations in the mid-stage sporadic Parkinson’s disease

Abstract

The alteration of pathological cortical surface may lead to the corresponding clinical manifestations of sporadic Parkinson's disease (sPD). Therefore, we investigated the correlates of cortical surface and clinical manifestations in the mid-stage sPD. Sixty seven mid-stage sPD patients and thirty five matched controls were performed the corticometry of magnetic resonance imaging (MRI) and the assessment of clinical manifestations including the demographic and disease-related characteristics, and underwent the final analysis of the correlates between cortical surface and clinical manifestations. The result revealed a significant correlation between CDT and Frontal-Sup-Orb-L, Frontal-Sup-Medial-L, Frontal-Mid-Orb-L and Rectus-L; SVFT and Frontal-Mid-L and Frontal-Inf-Tri-L; DF and Frontal-Sup-R, Frontal-Mid-R and Frontal-Sup-Medial-R; Webster and Occipital-Mid-R, Angular-R, Temporal-Sup-R and Temporal-Mid-R respectively in the mid-stage sPD patients. Our data suggested that the alterations of cortical surface in the left Frontal-Sup-Orb, Sup-Medial, Mid-Orb, Mid, Inf-Tri and Rectus, the right Frontal-Sup, Mid, Sup-Medial, and Occipital-Mid, Angular, Temporal-Sup and Temporal-Mid were the pathological base of some clinical manifestations including the cognitive impairment, the space structure, memory, attention, the abstract thinking, design, layout, utilization, digital, calculation, the time and spatial orientation concept, the operation sequence recognition and the partial motor dysfunctions in the mid-stage sPD, and that the dysfunctions of these brain regions contributed by the cortical surface lesion were closely correlated with some clinical manifestations of mid-stage sPD.

The Reduced Gray Matter Volume and Functional Connectivity of the Cerebellum in Type 2 Diabetes Mellitus with High Insulin Resistance

“…The Frontal_Sup_Orb is widely acknowledged to play a crucial role in self-awareness, coordination of sensory systems, emotional processing, and decision-making [47]. Prior literature has demonstrated the abnormalities of cortical surface and the association with the clock drawing task in the Frontal_Sup_Orb in sporadic Parkinson’s disease [48]. In the current study, the negative correlation of the functional connectivity between lobules I–V and Frontal_Sup_Orb and HbA1c was revealed in T2DM patients.…”

Does TRODAT-1 SPECT Uptake Correlate with Cerebrospinal Fluid α-Synuclein Levels in Mid-Stage Parkinson’s Disease?

“…The differences between left-and right-side PD onset have been contradictory. While no difference has been shown regarding neuropsychological profiles or motor deficits in early PD [20], left-side PD onset individuals demonstrated poorer visual memory, while right-side PD onset individuals showed lower verbal memory [22]. Right-sided patients exhibited reduced cognitive function [23].…”

“…Twenty-eight patients diagnosed with PD were evaluated by the Department of Functional Neurosurgery at the Hospital das Clínicas, assisted by the public health system. The inclusion criterion was mid-stage PD according to the established international guidelines [20]. The exclusion criteria were impairment of balance, swallowing, and speech disorders related to PD, anatomical abnormalities, and pre-existing uncontrolled medical conditions, as shown in Table 1.…”

Abnormal functional connectivity in psoriasis patients with depression is associated with their clinical symptoms

“…The middle frontal gyrus (MFG) is located in the frontal lobe of the cerebral cortex between the suprafrontal and subfrontal sulci and has been consistently found to be associated with processing emotional stimuli and emotional regulation ( Deng et al, 2016 ; Peng et al, 2021 ). Thus, changes in the brain activity of the MFG may lead to abnormal responses to emotional events ( Zhang et al, 2021 ).…”