3‐Hz subthreshold oscillations of CA2 neurons <i>In vivo</i>

Matsumoto, Nobuyoshi; Okamoto, Kazuki; Tobisawa, Yuki; Ikegaya, Yuji

doi:10.1002/hipo.22657

Cited by 30 publications

(22 citation statements)

References 31 publications

(39 reference statements)

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“…We found that during spontaneous theta activity, the peak and reversal of membrane potential oscillations shifted in phase, consistent with different phase-locking preferences at proximal and distal sectors. Other report also noted different theta modulation in pyramidal cells recorded around CA2 in mouse, but neurochemical confirmation was not available (Matsumoto et al, 2016). Two independent analyses provided additional support to this functional segregation along the transverse axis.…”

Section: Discussionmentioning

confidence: 86%

Proximodistal organization of the CA2 hippocampal area

Fernández-Lamo¹,

Gómez-Domínguez²,

Sánchez-Aguilera³

et al. 2018

Preprint

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Competitividad (MINECO) to LMP (BFU2015-66887-R) and the Fundación Tatiana Perez de Guzman el Bueno. DGD and MV were supported by a PhD fellowship from the Spanish Ministry of Economy (BES-2013-064171) and from the Ministry of Education, Culture and Sports (FPU12/03776), respectively. We thank to the Deisseroth lab for sharing their optogenetic constructs. VGAT-Venus transgenic rats were generated by Drs. Y. Yanagawa, M. Hirabayashi, and Y.Kawaguchi at the National Institute for Physiological Sciences (Okazaki, Japan) using pCS2-Venus provided by Dr. A. Miyawaki. VGAT line progenitors were provided by the National Bioresource Project Rat (Kyoto, Japan) 2The proximodistal axis is considered a major organizational principle of the hippocampus. Interfacing between the hippocampus and other brain systems, the CA2 region apparently breaks this rule. Apart from its specific role in social memory, CA2 has been involved in temporal and contextual memory but mechanisms remain elusive. Here, we used intracellular and extracellular recordings followed by neurochemical identification of single-cells to evaluate CA2 and surrounding areas in the rat. We found marked proximodistal trends of synaptic activity, as well as in subthreshold membrane potentials and phase-locked firing coupled to theta and gamma oscillations. Opposite proximodistal correlations between membrane potential fluctuations and theta sinks and sources at different layers revealed influences from up to three different generators. CA2 memory engrams established after a social memory task reflected these trends. We suggest that the structure and function of CA2 is segregated along the proximodistal hippocampal axis.

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Section: Discussionmentioning

confidence: 86%

Proximodistal organization of the CA2 hippocampal area

Fernández-Lamo¹,

Gómez-Domínguez²,

Sánchez-Aguilera³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…We found that during spontaneous theta activity, the peak and reversal of membrane potential oscillations shifted in phase, consistent with different phase-locking preferences at proximal and distal sectors. Other report also noted different theta modulation in pyramidal cells recorded around CA2 in mouse, but neurochemical confirmation was not available (Matsumoto et al., 2016). Three independent analyses provided additional support to this functional distribution along the transverse axis.…”

Section: Discussionmentioning

confidence: 93%

Proximodistal Organization of the CA2 Hippocampal Area

et al. 2019

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Summary The proximodistal axis is considered a major organizational principle of the hippocampus. At the interface between the hippocampus and other brain structures, CA2 apparently breaks this rule. The region is involved in social, temporal, and contextual memory function, but mechanisms remain elusive. Here, we reveal cell-type heterogeneity and a characteristic expression gradient of the transcription factor Sox5 within CA2 in the rat. Using intracellular and extracellular recordings followed by neurochemical identification of single cells, we find marked proximodistal trends of synaptic activity, subthreshold membrane potentials, and phase-locked firing coupled to theta and gamma oscillations. Phase-shifting membrane potentials and opposite proximodistal correlations with theta sinks and sources at different layers support influences from different current generators. CA2 oscillatory activity and place coding of rats running in a linear maze reflect proximodistal state-dependent trends. We suggest that the structure and function of CA2 are distributed along the proximodistal hippocampal axis.

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“…For instance, the analysis of membrane potential dynamics of identified cells from the DG to CA1 suggests striking regional organization across the proximodistal and deep-superficial axes both in awake and anesthetized conditions ( Table 3 ). During SWR under urethane, neuronal activity runs as an avalanche from the proximal CA3c mostly through superficial CA1 cells, while the activity of distal CA3a region and CA2 pyramidal neurons is mostly decreased [ 26 , 62 , 63 ]. At CA3c, interactions with hilar cell types and DG granule cells may be playing roles in shaping SWR initiation [ 64 – 66 ].…”

Section: Discussionmentioning

confidence: 99%

An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo

et al. 2021

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Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal–hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) and complemented the dataset with our own new data. By confronting the effect of brain state and recording methods, we highlight the equivalences and differences across conditions and offer a number of novel observations. We show how a heuristic approach based on oscillatory features of morphologically identified neurons can aid in classifying extracellular recordings of single cells and discuss future opportunities and challenges towards integrating single-cell phenotypes with circuit function.

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3‐Hz subthreshold oscillations of CA2 neurons In vivo

Cited by 30 publications

References 31 publications

Proximodistal organization of the CA2 hippocampal area

Proximodistal organization of the CA2 hippocampal area

Proximodistal Organization of the CA2 Hippocampal Area

An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo

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