Person-Based Versus Generalized Impulsivity Disinhibition in Frontotemporal Dementia and Alzheimer Disease

Paholpak, Pongsatorn; Carr, Andrew R.; Barsuglia, Joseph P.; Barrows, Robin J.; Jimenez, Elvira; Lee, Grace J.; Mendez, Mario F.

doi:10.1177/0891988716666377

Cited by 20 publications

(31 citation statements)

References 52 publications

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“…Previous research has shown that higher levels of PA are associated with impaired communication 36 and 1 study found that younger age was a significant predictor of rates and levels of aggressiveness. 37 We believe that the FTD patients 0 early loss of inhibition [38][39][40] may have contributed to PA in the early stages of their disease. Previous research has shown that criminal behavior, including violence, could be the first sign of FTD.…”

Section: Discussionmentioning

confidence: 94%

Physical aggression among patients with dementia, neuropathologically confirmed post‐mortem

Liljegren

Waldö

Englund

2017

Int J Geriat Psychiatry

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Section: Discussionmentioning

confidence: 94%

Physical aggression among patients with dementia, neuropathologically confirmed post‐mortem

Liljegren

Waldö

Englund

2017

Int J Geriat Psychiatry

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“…Indeed, previous studies (Lebreton et al, 2013;Bertoux et al, 2015) did not include behavioural scales to assess disinhibition. This is a critical point, as some reports showed that the measurement of impulsive behaviour can effectively differentiate bvFTD from AD (Paholpak et al, 2016;Grochmal-Bach et al, 2009), while cognitive tests may fail to do so (Flanagan et al, 2016;Hornberger et al, 2010;Collete et al, 2007;Perry et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Disinhibition in Frontotemporal Dementia and Alzheimer’s Disease: A Neuropsychological and Behavioural Investigation

Mariano

O’Callaghan

Guimarães

et al. 2019

J Int Neuropsychol Soc

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Objective:Cognitive tests of inhibitory control show variable results for the differential diagnosis between behavioural variant of Frontotemporal Dementia (bvFTD) and Alzheimer’s disease (AD). We compared the diagnostic accuracies of tests of inhibitory control and of a behavioural questionnaire, to distinguish bvFTD from AD.Methods:Three groups of participants were enrolled: 27 bvFTD patients, 25 AD patients, and 24 healthy controls. Groups were matched for gender, education, and socio-economic level. Participants underwent a comprehensive neuropsychological assessment of inhibitory control, including Hayling Test, Stroop, the Five Digits Test (FDT) and the Delay Discounting Task (DDT). Caregivers completed the Barratt Impulsiveness Scale 11th version (BIS-11).Results:bvFTD and AD groups showed no difference in the tasks of inhibitory control, while the caregiver questionnaire revealed that bvFTD patients were significantly more impulsive (BIS-11: bvFTD 76.1+9.5, AD 62.9+13, p < .001).Conclusions:Neuropsychological tests of inhibitory control failed to distinguish bvFTD from AD. On the contrary, impulsivity caregiver-completed questionnaire provided good distinction between bvFTD and AD. These results highlight the current limits of cognitive measures of inhibitory control for the differential diagnosis between bvFTD and AD, whereas questionnaire information appears more reliable and in line with clinical diagnostics.

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“… 14 This patient’s press of speech and other manic symptoms, are also consistent with the spectrum of behavioral disinhibition, one of the commonest manifestations of bvFTD. 1 , 16 , 17 Some disinhibited behaviors in bvFTD are highly associated with violations of social tact and personal boundaries, 16 , 18 as in this patient. Among patients with bvFTD, investigators report disinhibition associated with decreased volumes in the right amygdala, right ventromedial prefrontal cortex, and right anterior temporal cortex.…”

Section: Discussionmentioning

confidence: 62%

Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation

Mendez¹

2018

NDT

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Studies suggest a relationship of manic behavior and bipolar disorder (BD) with behavioral variant frontotemporal dementia (bvFTD). The nature of this relationship is unclear. This report presents a patient with initial manic behavior as the main manifestation of familial bvFTD from a novel progranulin (GRN) mutation. In contrast, there are other reports of a long background of BD preceding a diagnosis of bvFTD. A review of the literature and this patient suggest that manic symptoms result from damage to right frontotemporal neural structures from longstanding BD, as well as from bvFTD and other focal neurological disorders. In addition, there is a subgroup of patients with a probable genetic predisposition to both BD and bvFTD.

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Person-Based Versus Generalized Impulsivity Disinhibition in Frontotemporal Dementia and Alzheimer Disease

Abstract: Person-based disinhibition was predominant in bvFTD and correlated with the left STS. In both dementia, violations of social propriety and personal boundaries involved fronto-parieto-temporal network of Theory of Mind, whereas nonspecific disinhibition involved the OFC and aTL.

Cited by 20 publications

References 52 publications

Physical aggression among patients with dementia, neuropathologically confirmed post‐mortem

Physical aggression among patients with dementia, neuropathologically confirmed post‐mortem

Disinhibition in Frontotemporal Dementia and Alzheimer’s Disease: A Neuropsychological and Behavioural Investigation

Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation

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