Assessment of the Association between ZBTB20 rs9841504 Polymorphism and Gastric and Esophageal Cancer Susceptibility: A Meta-Analysis

Abstract

In summary, our work suggests that the ZBTB20 rs9841504 polymorphism is a protective factor for gastric cancer rather than esophageal cancer.

Genome‐wide association study identifies gastric cancer susceptibility loci at 12q24.11‐12 and 20q11.21

“…Among the remaining four loci that were identified in the GWAS of the Chinese population, 3q13.31 indicated significant association with the same risk allele ( P = 0.0167), whereas the remaining three loci did not. Concordant with this result, 3q13.31 was validated in the meta‐analysis . Considering the sufficient number of samples used in our imputation analysis (6171 cases and 27 178 controls), these results would be due to differences in host genetic background and/or H. pylori subtypes between Chinese and Japanese.…”

“…Concordant with this result, 3q13.31 was validated in the meta-analysis. 53 Considering the sufficient number of samples used in our imputation analysis (6171 cases and 27 178 controls), these results would be due to differences in host genetic background and/or H. pylori subtypes 54 between Chinese and Japanese.…”

ZBTB20 promotes cell migration and invasion of gastric cancer by inhibiting IκBα to induce NF-κB activation

“…Consistently, our data showed that ZBTB20 knockdown in gastric cancer cell lines markedly suppressed cell proliferation, invasion and migration while ZBTB20 overexpression significantly promoted those. However, Shi et al, found a significant association between the rs9841504 polymorphism in ZBTB20 and decreased gastric cancer susceptibility, suggested that the ZBTB20 rs9841504 polymorphism is a protective factor for gastric cancer [11]. Meanwhile, no statistical difference was found between the rs9841504 polymorphism in ZBTB20 and gastric cancer risk in other previous studies [16][17][18].…”

“…Zinc finger and BTB domain containing 20 (ZBTB20) has been implicated in developmental neurogenesis [7], glucose and lipid homoeostasis, and the tumorigenesis of glioblastoma [8], liver [9] and lung cancer [10]. Polymorphisms of ZBTB20 appeared to be associated with gastric cancer susceptibility in allelic, homozygous, dominant and recessive models, suggesting its role in gastric cancer [11]. NF-jB is activated in a variety of cancers as detected by phosphorylation and degradation of IjBa proteins, phosphorylation of RelA/p65, and elevated expression of NF-jB target genes.…”

Non-random distribution of gastric cancer susceptible loci on human chromosomes

“…Table 1 (Tab. 1) (References in Table 1: Chang et al, 2014[ 1 ]; Chen et al, 2015[ 2 ]; Cheng et al, 2015[ 3 ]; Dai et al, 2015[ 4 ]; Deng et al, 2014[ 5 ]; Gong et al, 2016[ 9 ]; Han et al, 2012[ 11 ]; He et al, 2013[ 12 ]; Hua et al, 2014[ 14 ]; Jia et al, 2017[ 16 ]; Kuang et al, 2014[ 17 ]; Li et al, 2015[ 20 ]; Li et al, 2016[ 18 ]; Li et al, 2017[ 19 ]; Liang et al, 2018[ 21 ]; Liu et al, 2011[ 23 ]; Liu et al, 2011[ 24 ]; Liu et al, 2014[ 25 ]; Liu et al, 2014[ 26 ]; Lu et al, 2012[ 27 ]; Ma et al, 2013[ 29 ]; Ma et al, 2013[ 30 ]; Ma et al, 2017[ 28 ]; Mo et al, 2016[ 31 ]; Mocellin et al, 2015[ 32 ]; Namazi et al, 2018[ 35 ]; Pabalan et al, 2015[ 36 ]; Peng and Xu, 2015[ 37 ]; Qi et al, 2016[ 38 ]; Qin et al, 2017[ 39 ]; Ribeiro et al, 2017[ 41 ]; Shen et al, 2014[ 47 ]; Shi et al, 2014[ 48 ]; Shi et al, 2017[ 49 ]; Shi et al, 2018[ 50 ]; Tian et al, 2012[ 52 ]; Wang et al, 2013[ 53 ]; Wang et al, 2014[ 54 ]; Wang et al, 2015[ 56 ]; Wang et al, 2015[ 57 ]; Wang et al, 2016[ 55 ]; Wu et al, 2015[ 58 ]; Xie et al, 2017[ 59 ]; Xu et al, 2014[ 61 ]; Xu et al, 2014[ 63 ]; Xu et al, 2015[ 62 ]; Xu et al, 2018[ 60 ]; Yadav et al, 2018[ 64 ]; Yan et al, 2013[ 65 ]; Yang et al, 2014[ 66 ]; Yang et al, 2016[ 67 ]; Ye et al, 2017[ 68 ]; Yu et al, 2014[ 69 ]; Zhang et al, 2012[ 72 ]; Zhang et al, 2013[ 71 ]; Zhang et al, 2015[ 74 ]; Zhang et al,...…”