Current advances in electrospun gelatin-based scaffolds for tissue engineering applications

Abstract

The development of biomimetic highly-porous scaffolds is essential for successful tissue engineering. Electrospun nanofibers are highly versatile platforms for a broad range of applications in different research areas. In the biomedical field, micro/nanoscale fibrous structures have gained great interest for wound dressings, drug delivery systems, soft and hard-tissue engineering scaffolds, enzyme immobilization, among other healthcare applications. In this mini-review, electrospun gelatin-based scaffolds for a variety of tissue engineering applications, such as bone, cartilage, skin, nerve, and ocular and vascular tissue engineering, are reviewed and discussed. Gelatin blends with natural or synthetic polymers exhibit physicochemical, biomechanical, and biocompatibility properties very attractive for scaffolding. Current advances and challenges on this research field are presented.

Electrospun nanofibers comprising of silk fibroin/gelatin for drug delivery applications: Thyme essential oil and doxycycline monohydrate release study

“…This protein also has arginine‐glycine‐aspartate (RGD) sequences, which provide cell attachment sites. Due to its superior properties, GT also has been extensively employed as a biomaterial for both tissue engineering and drug delivery systems . Thus, it is a good candidate for blending with the SF to promote the biological properties of the resulting composite biomaterial .…”

“…Due to its superior properties, GT also has been extensively employed as a biomaterial for both tissue engineering and drug delivery systems. 9,10 Thus, it is a good candidate for blending with the SF to promote the biological properties of the resulting composite biomaterial. 11,12 Okhawilai et al 13 showed that by blending SF with GT, its mass loss rate is increased.…”

Functionalized TiCu/Ti‐Cu‐N‐Coated 3D‐Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment

“…The in vivo biocompatibility and the osteogenic activity of the coating are important highlights of its use as an implant material. [27] To evaluate scaffold osteogenesis and osteointegration properties, we performed histological analyses based on hematoxylin-eosin (H&E), Masson Trichrome ( Figure 6) and Van-Gieson (V-G) staining (Figure 7a-d). At 4 and 8 weeks, the coating group was observed to have significantly more new bone than the Ti6Al4V group (p < 0.05).…”

Theoretical cross‐link density of the nanofibrous scaffolds

“…Nowadays, the biopolymers are interested due to their hydrophilicity, degradability, and biocompatibility for preparation of biodegradable scaffolds. However, the main disadvantages of these types of materials are the weak mechanical properties and fast biodegradability . To overcome the issues, cross‐linking of the scaffolds has been usually employed.…”

“…However, the main disadvantages of these types of materials are the weak mechanical properties and fast biodegradability. 1 To overcome the issues, cross-linking of the scaffolds has been usually employed. There are several methods for the determination of the cross-link density.…”