Tourette syndrome, obsessive compulsive behavior, and dysmorphic features in a patient with deletions at chromosome 18q22.1 and chromosome 13q12.3-q13.1

Bhatti, Danish; Balasetti, V.; Malgireddy, Kalyan; Rush, Eric T.; Torres-Russotto, Diego

doi:10.1016/j.parkreldis.2016.09.002

Cited by 1 publication

(1 citation statement)

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“…The complexities of genetic contributions to OCD and other neuropsychiatric/ neurodevelopmental disorders continue to be unraveled by research. One report noted deletions at two chromosomes (18q22.1 and 13q12.3-q13.1) in a person with OCD along with Tourette syndrome and dysmorphism (89). Given the enormous entanglements of genetic influence on OCD and the difficulties of OCD itself, genetic counseling is recommended for families (i.e., parents, others) to help them deal with OCD in a family member (i.e., a child or others) (90).…”

Section: Genetic Etiologymentioning

confidence: 99%

Obsessive-compulsive disorder in children and adolescents: epidemiology, diagnosis and management

Nazeer¹,

Latif²,

Mondal³

et al. 2020

Transl Pediatr

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Obsessive-compulsive disorder (OCD) can be found in about 4% of the general population and is characterized by various compulsions and obsessions that interfere with the person's quality of life from a mild to severe degree. The following discussion reflects on current concepts in this condition, including its epidemiology and etiologic underpinnings (behavioral, neurological, immunological, gastroenterological, as well as genetic). The interplay of PANS and PANDAS are included in this review. In addition, the core concepts of OCD diagnosis, differential diagnosis, and co-morbidities are considered. It is stressed that the quality of life for persons with pediatric OCD as well as for family members can be quite limited and challenged. Thus, principles of management are presented as a guide to improve the quality of life for these persons as much as possible.

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Section: Genetic Etiologymentioning

confidence: 99%