Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides

Faqueti, Larissa; Brieudes, Vincent; Halabalaki, Maria; Skaltsounis, Alexios Léandros; Nascimento, Leandro F.; Barros, Wellinghton M.; Santos, Adair R.S.; Biavatti, Maique W.

doi:10.1016/j.jep.2016.09.025

Cited by 28 publications

(16 citation statements)

References 45 publications

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“…In the present study, we also observed that flavonoids in A. conyzoides exhibited obvious anti-inflammation effects on bacterial vaginitis in mice. To our knowledge, A. conyzoides is widely used as a traditional medicine to cure various diseases due to its anti-inflammatory, antinociceptive and antibacterial properties [20]. However, the safety of phytoconstituents in A. conyzoides is still uncertain at present.…”

Section: Agingmentioning

confidence: 99%

Systematic analysis of bacteriostatic mechanism of flavonoids using transcriptome and its therapeutic effect on vaginitis

Zeyan

Lin

Zhang

et al. 2020

Aging

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The flavonoids in Ageratum conyzoides L. have been used in traditional medicine due to its anti-inflammatory and antibacterial properties. However, the specific mechanism of its antibacterial effect, and the potential therapeutic effect on vaginitis have not been well explained. The growth curves of E. coli, S. aurues, and P. aeruginosa after treatment with flavonoids were measured. The influences of flavonoids on the conductivity of bacterial culture medium and exudation of bacterial nucleic acid were also detected. Transcriptomics analysis was applied to analyze the potential mechanism of flavonoids. Flavonoids significantly suppressed the growth curves of E. coli, S. aurues, and P. aeruginosa, and increased the conductivity of bacteria and nucleic acid exudation. Transcriptomics analysis indicated that flavonoids could suppress bacteria by affecting the transcription and metabolism pathways. The obvious therapeutic effect of flavonoids on bacterial vaginitis was also observed. This study systematically analyzed the bacteriostatic mechanism of flavonoids, which should be helpful to develop new drugs based on the bacteriostatic effect of flavonoids.

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Section: Agingmentioning

confidence: 99%

Systematic analysis of bacteriostatic mechanism of flavonoids using transcriptome and its therapeutic effect on vaginitis

Zeyan

Lin

Zhang

et al. 2020

Aging

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“…In 2012, Rahman et al also demonstrated anti‐inflammatory and analgesic properties of A. conyzoides . A recent study with a polymethoxyflavones extract of A. conyzoides reported pronounced antinociceptive effects in mice models of acute nociception and inflammation, and the authors suggested that in part the effect was due to negatively modulating prostanoids and proinflammatory cytokine IL‐1β at peripheral and central levels . In a similar study, A. conyzoides extract was shown to inhibit leukocyte influx and protein concentration of the exudate, as well as reducing the levels of several pro‐inflammatory mediators.…”

Section: Discussionmentioning

confidence: 91%

Ageratum conyzoides L. inhibits 5‐alpha‐reductase gene expression in human prostate cells and reduces symptoms of benign prostatic hypertrophy in otherwise healthy men in a double blind randomized placebo controlled clinical study

et al. 2017

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A double-blind, randomized, placebo-controlled clinical trial assessed the efficacy and safety of Ageratum conyzoides in treating benign prostatic hypertrophy (BPH). In this study, 109 men with medically diagnosed BPH, aged 41-76 years, were administered the investigational product, A. conyzoides extract at a dose of 250 mg/d or placebo, q.d. for 12 weeks. The primary outcome measures were the International Prostate Symptom Score (IPSS), daily urinary frequency and safety evaluations. The secondary outcome measures were testosterone, dihydrotestosterone, oestradiol, sex hormone binding globulin (SHBG), Dehydroepiandrosterone sulfate (DHEA-S) and cortisol levels, and prostate specific antigen (PSA), lipids, blood glucose, the Aging Male's Symptom (AMS) Score and sexual function assessed by Derogatis Interview for Sexual Functioning-Self Report (DISF-SR). The effect of A. conyzoides L extract on gene expression of 5-alpha-reductase in human prostate cells was also investigated to elucidate a potential mechanism of action. The clinical study, showed a significant reduction in total IPSS score (p < 0.01) and day- and night-time urinary frequency (P < 0.01) over time after treatment with A. conyzoides. Steroid hormones, SHBG, PSA levels, lipids, and blood glucose remained within healthy reference range in both groups. There were no changes in AMS or DISF-SR in either group. Gene arrays demonstrated that A. conyzoides extract was effective in reducing the expression of mRNA coding for 5-alpha-reductase types 2 and 1 in human prostate epithelial cells. The overall results indicate that A. conyzoides may be an effective treatment for reducing symptoms of BPH in healthy men, in part, through inhibition of 5-alpha-reductase enzyme activity. © 2017 BioFactors, 43(6):789-800, 2017.

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“…Standardized extract of polymethoxyflavones has been studied for anti‐inflammatory activity of A . conyzoides (Faqueti et al, ).…”

Section: Pharmacologymentioning

confidence: 99%

Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

Yadav

Ganie

Singh

et al. 2019

Phytotherapy Research

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Ageratum conyzoides L. (Asteraceae) is an invasive aromatic herb with immense therapeutic importance. The herb is distributed in tropical and subtropical regions. A. conyzoides has imparted numerous ethnomedicinal uses because it has been used to cure various ailments that include leprosy, skin disorders, sleeping sickness, rheumatism, headaches, dyspnea, toothache, pneumonia and many more. A number of phytoconstituents have been scrutinized such as alkaloids, flavonoids, terpenes, chromenes, and sterols from almost every part of this plant. These phytoconstituents have shown diverse pharmacological properties including antimicrobial, anti‐inflammatory, analgesic, antioxidant, anticancer, antiprotozoal, antidiabetic, spasmolytic, allelopathy, and many more. The plant A. conyzoides has provided a platform for doing pharmaceutical and toxicological research in order to isolate some promising active compounds and authenticate their safety in clinical uses. A. conyzoides provides principal information for advanced studies in the field of pharmaceutical industries and agriculture. Present review article describes the cytogenetics, ethnobotany, phytochemistry, pharmacology, and toxicological aspects of A. conyzoides.

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Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides

Cited by 28 publications

References 45 publications

Systematic analysis of bacteriostatic mechanism of flavonoids using transcriptome and its therapeutic effect on vaginitis

Systematic analysis of bacteriostatic mechanism of flavonoids using transcriptome and its therapeutic effect on vaginitis

Ageratum conyzoides L. inhibits 5‐alpha‐reductase gene expression in human prostate cells and reduces symptoms of benign prostatic hypertrophy in otherwise healthy men in a double blind randomized placebo controlled clinical study

Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

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