The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice

Casteras, Sylvie; Abdul-Wahed, Aya; Soty, Maud; Vulin, Fanny; Guillou, Hervé; Campana, Mélanie; Stunff, Hervé Le; Pirola, Luciano; Rajas, Fabienne; Mithieux, Gilles; Gautier‐Stein, Amandine

doi:10.1007/s00125-016-4097-y

Cited by 11 publications

(7 citation statements)

References 52 publications

(76 reference statements)

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“…Several studies have suggested that improved glucose and insulin tolerance is associated with the inhibition of hepatic glucose production. 36 , 37 , 38 These, together with the improved glucose, insulin, and leptin levels in the FA-treated group, led us to hypothesize that FA might reduce hepatic glucose production in HFD-induced obese mice. To address this question, we examined the expression of the rate limiting enzymes for gluconeogenesis, PEPCK and G6P.…”

Section: Resultsmentioning

confidence: 99%

4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1

Kinyua

Doan

et al. 2018

Exp Mol Med

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4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) is known to have numerous beneficial health effects, including anti-obesity and anti-hyperglycemic properties. However, the molecular networks that modulate the beneficial FA-induced metabolic effects have not been well elucidated. In this study, we explored the molecular mechanisms mediating the beneficial metabolic effects of FA. In mice, FA protected against high-fat diet-induced weight gain, reduced food intake and exhibited an overall improved metabolic phenotype. The food intake suppression by FA was accompanied by a specific reduction in hypothalamic orexigenic neuropeptides, including agouti-related protein and neuropeptide Y, with no significant changes in the anorexigenic peptides pro-opiomelanocortin and cocaine and amphetamine-regulated transcript. FA treatment also inhibited fat accumulation in the liver and white adipose tissue and suppressed the expression of gluconeogenic genes, including phosphoenolpyruvate carboxylase and glucose-6-phosphatase. Furthermore, we show that FA phosphorylated and inactivated the transcription factor FoxO1, which positively regulates the expression of gluconeogenic and orexigenic genes, providing evidence that FA might exert its beneficial metabolic effects through inhibition of FoxO1 function in the periphery and the hypothalamus.

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Section: Resultsmentioning

confidence: 99%

4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1

Kinyua

Doan

et al. 2018

Exp Mol Med

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“…FGF21 is a pleiotropic secretion protein, which possesses multiple metabolic benefits including ameliorating insulin resistance, improving hepatic lipid accumulation, and extending lifespan [ 24 , 40 – 42 ]. In the past decades, the bulk of scientific research focused on the mechanism of FGF21 regulating glucose and lipid metabolism in obesity and diabetes.…”

Section: Discussionmentioning

confidence: 99%

Fibroblast Growth Factor 21 Promotes C2C12 Cells Myogenic Differentiation by Enhancing Cell Cycle Exit

Liu

Wang

Zhao

et al. 2017

BioMed Research International

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Fibroblast growth factor 21 (FGF21), a secretion protein, functions as a pivotal regulator of energy metabolism and is being considered as a therapeutic candidate in metabolic syndromes. However, the roles of FGF21 in myogenic differentiation and cell cycle remain obscure. In this study, we investigated the function of FGF21 in myogenesis and cell cycle exit using C2C12 cell line. Our data showed that the expression of myogenic genes as well as cell cycle exit genes was increased after FGF21 overexpression, and FGF21 overexpression induces cell cycle arrest. Moreover, cell cycle genes were decreased in FGF21 overexpression cells while they were increased in FGF21 knockdown cells. Further, FGF21/P53/p21/Cyclin-CDK has been suggested as the key pathway for cell cycle exit mediated by FGF21 in C2C12 cells. Also, we deduce that FGF21 promotes the initiation of myogenic differentiation mainly through enhancing cell cycle exit of C2C12 cells. Taken together, our results demonstrated that FGF21 promotes cell cycle exit and enhances myogenic differentiation of C2C12 cells. This study provided new evidence that FGF21 promotes myogenic differentiation, which could be useful for better understanding the roles of FGF21 in myogenesis.

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“…Moreover, the quality and quantity of VAT play significant roles in adipocyte function and are related to insulin resistance [33]. It was also concluded about the existence of a strong correlation between glucose production and insulin sensitivity in SAT [34].…”

Section: Introductionmentioning

confidence: 99%

Analytical methods used for the characterisation of specific features of biological tissues related with obesity: A review

Brimas¹,

Raudonis²,

Kareiva³

2022

chemija

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Obesity has become a global pandemic, leading to the development of many common disorders, such as type 2 diabetes, metabolic syndrome and cardiovascular diseases, and even increases the risk of several cancers. The adipose tissue of obese patients was characterised as a tissue microenvironment composed of adipose tissue macrophages, precursor and hypertrophic adipocytes, and other immune cells that predominantly produce pro-inflammatory cytokines for chronic, low-grade inflammation. In this study, several analytical techniques, such as gas and liquid chromatography, Fourier transform infrared (FTIR) and Raman spectroscopies, nuclear magnetic resonance (NMR) spectroscopy, scanning electron microscopy (SEM) and elemental analysis, were discussed as the main tools used for the characterisation of adipose tissue samples. The emphasis was focused on the relation between the obtained results which provide information about the chemical and structural composition of adipose tissue layers in the human body, as well as main microstructural features and obesity. It was demonstrated that these methods are indispensable tools in order to investigate some special features of human adipose tissue, identifying chemical composition and structural features. Moreover, the summarised results let us to conclude that such characterisation of adipose tissue is an essential step for the possible prediction of the appearance of symptoms of different diseases.

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The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice

Cited by 11 publications

References 52 publications

4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1

4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1

Fibroblast Growth Factor 21 Promotes C2C12 Cells Myogenic Differentiation by Enhancing Cell Cycle Exit

Analytical methods used for the characterisation of specific features of biological tissues related with obesity: A review

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