Eosinophilic tubulointerstitial nephritis on treatment with isotretinoin

Aksoy, Gülşah Kaya; Koyun, Mustafa; Akkaya, Bahar; Çomak, Elif; Gemici, Atilla; Akman, Sema

doi:10.1007/s00431-016-2778-7

Cited by 6 publications

(10 citation statements)

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“…In this case report, a patient was diagnosed with acute tubulointerstitial nephritis. Pathological signs of renal biopsy sections had been revealed interstitial mononuclear cell and eosinophilic infiltration in this case (11). Armaly et al (10) had been reported a 17-year-old female who experienced acute kidney injury to using isotretinoin.…”

Section: Discussionmentioning

confidence: 50%

“…There are conflicting reports about safety of oral isotretinoin on kidneys. Some authors reported that it may be toxic (9)(10)(11)(12)(13). Some authors suggested that it is safe on kidneys (14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

“…Some authors suggested that it is safe on kidneys (14)(15)(16)(17). Kaya Aksoy et al (11) had been reported that isotretinoin may cause drug-related acute tubulointerstitial nephritis. In this case report, a patient was diagnosed with acute tubulointerstitial nephritis.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors suggested that isotretinoin is not safe for kidney in patients with lupus nephritis (LN) and Nephritic syndrome (9)(10)(11). But despite all this case reports Miziolek et al (17) reported a review and suggested benefits of isotretinoin therapy for patients with kidney diseases.…”

Section: Discussionmentioning

confidence: 99%

“…There are some reports that isotretinoin had toxic effects such as hyperuricemia, acute kidney injury, interstitial nephritis and Nephritic Syndrome (8)(9)(10)(11)(12)(13). Severe rhabdomyolysis with mortal outcome was reported with using the drug (8).…”

Section: Introductionmentioning

confidence: 99%

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Isotretinoin is a Safety Therapy on Kidney: A Retrospective Study

Parlak¹,

Ünal²,

Aksoy³

2018

tdd

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Objective: Isotretinoin is widely used in severe acne treatment. The drug leads to several adverse effects; skin and mucous membranes are frequently affected. It may also cause serious and fatal adverse effects like kidney damage. The aim of this study is to determine the safety of isotretinoin usage on kidney functions in patients with acne vulgaris. Methods: Eighty six patients with severe acne vulgaris and receiving 0.5 mg/kg/day of isotretinoin treatment were included in the study and evaluated retrospectively. Serum urea, creatinine, complete blood count, aspartate aminotransferase, alanine aminotransferase, lipid profile datas were obtained from patient files. Glomerular filtration rate (GFR) was measured at the baseline of treatment, 3 rd and 6 th months of treatment. Results: We detected significant increases in levels of creatinine on the third month (p=0.041), but it was not clinically significant, and there was no significant difference in creatinine levels at 6 th month. There were no significant differences among the baseline, 3 rd month (p=0.066) and 6 th month (p=0.429) of GFR values. Conclusion:We think that isotretinoin is safe for the kidneys but patients with high creatinine levels at the baseline of treatment should be closely followed up.Amaç: Şiddetli akne tedavisinde isotretinoin yaygın olarak kullanılmaktadır. İlaç çok sayıda yan etki oluşturmaktadır; deri ve mukoz membranlar ise sıklıkla etkilenmektedir. Ayrıca böbrek hasarı gibi ciddi ve ölümcül yan etkiler de görülebilmektedir. Bu çalışmanın amacı, akne vulgarisli hastalarda isotretinoin kullanımının böbrek fonksiyonları üzerindeki güvenilirliğini değerlendirmektir. Yöntemler: Şiddetli aknesi olan ve 0,5 mg/kg/gün isotretinoin tedavisi alan 86 hasta çalışmaya alındı ve geriye dönük değerlendirildi. Serum üre, kreatinin, tam kan sayımı, aspartat aminotransferaz, alanin aminotransferaz, lipit profil verileri hasta dosyalarından elde edildi. Glomerüler filtrasyon hızı (GFR) tedavi başlangıcında, tedavinin 3. ve 6. ayında hesaplandı. Bulgular: Tedavinin 3. ayında kreatinin değerlerinde anlamlı artış gözlendi (p=0,041); ancak klinik olarak anlamlı değildi, tedavinin 6. ayında ise kreatinin değerlerinde anlamlı farklılık yoktu. Başlangıç, 3. ay (p=0,066) ve 6. ay (p=0,429) GFR değerleri arasında anlamlı farklılık görülmedi. Sonuç: İsotretinoinin böbrekler için güvenilir olduğunu düşünüyoruz; ancak tedavi başlangıcında kreatin değeri yüksek olan hastalar yakın takip edilmelidir. Anahtar kelimeler: İsotretinoin, akne vulgaris, kreatinin, üre, böbrek fonksiyonu, böbrek hastalığında diyet modifikasyonu Öz

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Section: Discussionmentioning

confidence: 50%