The Prevalence of Helicobacter pylori Infection in Symptomatic Children: A 13-Year Observational Study in the Lower Silesian Region

Biernat, Monika; Iwańczak, Barbara; Bińkowska, Aldona; Grabińska, Joanna; Gościniak, Grażyna

doi:10.17219/acem/44372

Cited by 18 publications

(36 citation statements)

References 27 publications

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“…The highest prevalence of infection was found in the year 2000 (23.06%) and the lowest in the year 2010 (8.90%). The prevalence of NHPH infection was low (0.2%) …”

Section: Epidemiologymentioning

confidence: 96%

“…The prevalence of NHPH infection was low (0.2%). 3 A systematic survey of H. pylori infection prevalence by 13 C urea breath test (UBT) was conducted from January 2007 to December 2014 in 12,796 symptomatic children in China. The overall prevalence of H. pylori infection was 18.6%, with a significant increase with age (14.8%, 20.2% and 25.8% in 3-6, 7-11 and 12-17 year age groups, respectively) and a significant decrease with time, from 21.6% in 2007 to 17.2% in 2014.…”

Section: Epidemiologymentioning

confidence: 99%

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Helicobacter pylori infection in children

2017

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Helicobacter pylori infection in children differs from that in adults, from the point of view of epidemiology, host response, clinical features, related diseases, and diagnosis, as well as treatment strategies. The prevalence of H. pylori infection, in both children and adults, is decreasing in the Western World as well as in some developing countries, which contrasts with the increase in childhood asthma and allergic diseases. Recurrent abdominal pain is not specific during H. pylori infection in children. The role of H. pylori infection and failure to thrive, children's growth, type I diabetes mellitus (T1DM) and celiac disease remains controversial. The main initial diagnosis is based on upper digestive endoscopy with biopsy-based methods. Nodular gastritis may be a pathognomonic endoscopic finding of childhood H. pylori infection. The infection eradication control is based on validated noninvasive tests. The main cause of treatment failure of H. pylori infection is its clarithromycin resistance. We recommend standard antibiotic susceptibility testing of H. pylori in pediatric patients prior to the initiation of eradication therapy. H. pylori treatment in children should be based on an evaluation of the rate of eradication in the local population, a systematic use of a treatment adapted to the susceptibility profile and a treatment compliance greater than 90%. The last meta-analysis in children did not show an advantage for sequential therapy when compared to a 14-day triple therapy. Finally, the high rate of antibiotic resistance responsible for therapy failure in recent years justifies the necessity of a novel vaccine to prevent H. pylori infection in children.

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“…The highest prevalence of infection was found in the year 2000 (23.06%) and the lowest in the year 2010 (8.90%). The prevalence of NHPH infection was low (0.2%) …”

Section: Epidemiologymentioning

confidence: 96%

Section: Epidemiologymentioning

confidence: 99%

Helicobacter pylori infection in children

2017

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“…The prevalence of the Helicobacter pylori infection differs worldwide among the paediatric population. It has decreased in some countries, especially high‐income countries, and some authors have attributed this to improvements in socio‐economic status .…”

Section: Discussionmentioning

confidence: 99%

“…Another reason for more considerable Helicobacter pylori testing and treatment in children is the declining incidence observed in some countries . Since 1992, when the results of the first Polish epidemiological study were published, the prevalence of Helicobacter pylori among children has more than halved, from above 40% to approximately 15% in 2006 and 2010 .…”

Section: Introductionmentioning

confidence: 99%

No association between Helicobacter pylori infection and gastrointestinal complaints in a large cohort of symptomatic children

Chobot

Porębska²,

Krzywicka³

et al. 2019

Acta Paediatrica

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Aim: This Polish study estimated the prevalence of the Helicobacter pylori infection in symptomatic children aged 3-18 and investigated its association with gastrointestinal complaints.Methods: We prospectively enrolled 1984 children (54% female) with a mean age of 9.5 AE 4.1 years, from Silesia, Poland, for the Good Diagnosis Treatment Life screening programme from 2009 to 2016. They underwent a 13 C-isotope-labelled urea breath test (UBT) to assess their Helicobacter pylori status, making this the biggest Polish study to use this approach. Further analysis included parental-reported gastrointestinal symptoms and standard deviation scores (SDS) of anthropometric measurements.Results: The Helicobacter pylori infection was identified in 220 (11%) children (48% female) and was independent of age and sex. The frequency of symptoms did not differ between Helicobacter positive and negative children (all p > 0.05). Children with a positive UBT result had a lower body mass SDS (À0.41 AE 0.98 versus À0.26 AE 1.01, p = 0.04) and height SDS (À0.45 AE 1.34 versus À0.23 AE 1.27, p = 0.02), but similar body mass index SDS.Conclusion: We found a low prevalence of Helicobacter pylori in symptomatic children, and positive UBT results were not associated with symptoms that suggested Helicobacter pylori infections. Our findings support the 2017 European and North American guidelines for Helicobacter infections in children.

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“…A sharp decrease in the trend of H. pylori prevalence and gastric cancer incidence was observed throughout Europe (Roberts et al, 2016). In a group of 8,661 symptomatic children from Poland, H. pylori was identified in 1,390 (16.05%) children (Biernat et al, 2016). The H. pylori prevalence was lower in the year 2010 (8.90%) than in the year 2000 (23.06%).…”

Section: The Prevalence Of H Pylori Infectionmentioning

confidence: 99%

Novel and Effective Therapeutic Regimens for Helicobacter pylori in an Era of Increasing Antibiotic Resistance

Zhu

Lü

2017

Front. Cell. Infect. Microbiol.

130

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Helicobacter pylori (H. pylori) is a common gastrointestinal bacterial strain closely associated with the incidence of chronic gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue lymphoma, and gastric cancer. A current research and clinical challenge is the increased rate of antibiotic resistance in H. pylori, which has led to a decreased H. pylori eradication rate. In this article, we review recent H. pylori infection and reinfection rates and H. pylori resistance to antibiotics, and we discuss the pertinent treatments. A PubMed literature search was performed using the following keywords: Helicobacter pylori, infection, reinfection, antibiotic resistance, bismuth, proton pump inhibitors, vonoprazan, susceptibility, quintuple therapy, dual therapy, and probiotic. The prevalence of H. pylori has remained high in some areas despite the decreasing trend of H. pylori prevalence observed over time. Additionally, the H. pylori reinfection rate has varied in different countries due to socioeconomic and hygienic conditions. Helicobacter pylori monoresistance to clarithromycin, metronidazole or levofloxacin was common in most countries. However, the prevalence of amoxicillin and tetracycline resistance has remained low. Because H. pylori infection and reinfection present serious challenges and because H. pylori resistance to clarithromycin, metronidazole or levofloxacin remains high in most countries, the selection of an efficient regimen to eradicate H. pylori is critical. Currently, bismuth-containing quadruple therapies still achieve high eradication rates. Moreover, susceptibility-based therapies are alternatives because they may avoid the use of unnecessary antibiotics. Novel regimens, e.g., vonoprazan-containing triple therapies, quintuple therapies, high-dose dual therapies, and standard triple therapies with probiotics, require further studies concerning their efficiency and safety for treating H. pylori.

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The Prevalence of Helicobacter pylori Infection in Symptomatic Children: A 13-Year Observational Study in the Lower Silesian Region

Cited by 18 publications

References 27 publications

Helicobacter pylori infection in children

Helicobacter pylori infection in children

No association between Helicobacter pylori infection and gastrointestinal complaints in a large cohort of symptomatic children

Novel and Effective Therapeutic Regimens for Helicobacter pylori in an Era of Increasing Antibiotic Resistance

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