“…Tripartite motif‐containing (TRIM) proteins belong to the tripartite motif family and contain one coiled‐coil region and three zinc‐binding domains including one RING, one B‐box type 1, and one B‐box type 2 domains. Previous studies have shown that TRIM family proteins play important roles in transcriptional control, viral suppression, energy metabolism, development and cellular differentiation, immune response, proliferation, cancer and genome stability, etc Results from others and our group have shown that tripartite motif‐containing 28 (TRIM28) mediates the differentiation of murine embryonic stem cells into cardiomyocytes, angiogenesis, and endothelial inflammatory response . Tripartite motif‐containing 27 (TRIM27) is involved in cell proliferation and transcriptional repression .…”