Clinical profile of children with cerebral palsy born term compared with late‐ and post‐term: a retrospective cohort study

Frank, Russell; Garfinkle, Jarred; Oskoui, Maryam; Shevell, M.

doi:10.1111/1471-0528.14240

Cited by 13 publications

(11 citation statements)

References 31 publications

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“…Long-term neurodevelopmental disabilities frequently associated with severe jaundice with or without a diagnosis of bilirubin encephalopathy include choreo-athetoid cerebral palsy, [47][48][49] auditory spectrum disorders, 37,[50][51][52][53] and general developmental delays. 30,54 A growing number of studies are now exploring the risk of bilirubin-induced neurotoxicity in jaundiced infants based on unbound bilirubin rather than serum/plasma bilirubin.…”

Section: Long-term Sequelaementioning

confidence: 99%

Neonatal hyperbilirubinaemia: a global perspective

Olusanya

Kaplan

Hansen

2018

The Lancet Child & Adolescent Health

207

195

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Hyperbilirubinaemia, presenting as jaundice, is a ubiquitous and frequently benign condition in newborn babies but is a leading cause of hospitalisation in the first week of life. In some infants jaundice can become severe, progressing to acute bilirubin encephalopathy and kernicterus with a substantial risk of neonatal mortality and long-term neurodevelopmental impairments. Severe hyperbilirubinaemia and its sequelae continue to occur in industrialised countries with functioning medical systems and a disproportionately high burden also persists in low-income and middle-income countries due primarily to delays in delivering effective treatments that are routinely available in high-income countries. In this Review we summarise up-to-date evidence on the epidemiology of neonatal jaundice including its global burden based on estimates of its prevalence, and both fatal and non-fatal health outcomes. We also discuss the management of severe hyperbilirubinaemia including the prevention of kernicterus, and highlight future directions for research.

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Section: Long-term Sequelaementioning

confidence: 99%

Neonatal hyperbilirubinaemia: a global perspective

Olusanya

Kaplan

Hansen

2018

The Lancet Child & Adolescent Health

207

195

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“…12 Observational studies have also suggested an increased risk of neonatal encephalopathy in children with cerebral palsy associated with delivery at 41 weeks or greater versus less than 41 weeks. 13 Thus, the current data suggest that 39 weeks' gestation is the optimal gestational age for delivery for the baby, as it avoids the morbidity associated with early term birth and reduces the risk of antepartum stillbirth post term.…”

Section: Neonatal Risksmentioning

confidence: 90%

Delivery at Term

Walker

Thornton

2018

Clinics in Perinatology

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There is growing evidence from randomized trials that induction of labor at or near term does not increase cesarean delivery; observational data show that the optimal gestation for spontaneous delivery for the baby is 39 weeks. Elective cesarean at these gestations is also sometimes considered, but evaluating the associated risks is complex. For the baby, although cesarean obviates the risks of labor, it carries a risk of respiratory problems, which may be severe. For the mother, cesarean is more dangerous than vaginal and emergency cesarean is more dangerous than elective. The authors consider the evidence base for near-term induction of labor and cesarean for a range of scenarios.

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“…To date, CP has no cure and would cost millions of healthcare expenditure, making CP as a severe public health problem that brings enormous burden for patient families [2,8]. Preterm birth and asphyxia result from dystocia are the most common risk factors for CP [9,10]. Administration of magnesium sulfate for women at risks of premature delivery and cooling therapy for infants at high risks of CP are considered to be effective preventive methods [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Genome-wide Analysis of Circular RNAs and Validation of hsa_circ_0086354 As a Promising Biomarker for Early Diagnosis of Cerebral Palsy

Bian

Wu³

et al. 2021

Preprint

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Background: Cerebral palsy (CP) is a spectrum of non-progressive motor disorders caused by brain injury during fetal or postnatal periods. Current diagnosis of CP mainly relies on neuroimaging and motor assessment. Here, we aimed to explore novel biomarkers for early diagnosis of CP. Methods: Blood plasma from five CP children and their healthy twin brothers/sisters was analyzed by gene microarray to screen out differentially expressed RNAs. Selected differentially expressed circular RNAs (circRNAs) were further validated using quantitative real-time PCR. Receiver operating characteristic (ROC) curve analysis was used to evaluate the value of using hsa_circ_0086354 as a biomarker of CP.Results: 43 up-regulated circRNAs and 2 down-regulated circRNAs were obtained by difference analysis (fold change>2, p<0.05), among which five circRNAs related to neuron differentiation and neurogenesis were chosen for further validation. Additional 30 pairs of CP children and healthy controls were recruited and five selected circRNAs were further detected, showing that hsa_circ_0086354 was significantly down-regulated in CP plasma compared with control, which was highly in accord with microarray analysis. ROC curve analysis showed that the area under curve (AUC) to discriminate CP children and healthy controls using hsa_circ_0086354 was 0.967, the sensitivity was 0.833 and the specificity was 0.966. Moreover, hsa_circ_0086354 was predicted as a competitive endogenous RNA for miR-181a, miR-4741 and miR-4656, and much literature evidence suggested that miR-181a may be a key target of hsa_circ_0086354 to regulate neuronal survival and neuronal differentiation. Conclusion: Hsa_circ_0086354 was significantly down-regulated in blood plasma of CP children, which may be a novel competent biomarker for early diagnosis of CP.

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Clinical profile of children with cerebral palsy born term compared with late‐ and post‐term: a retrospective cohort study

Abstract: Children with cerebral palsy born early/full-term have similar outcomes to those born late/post-term.

Cited by 13 publications

References 31 publications

Neonatal hyperbilirubinaemia: a global perspective

Neonatal hyperbilirubinaemia: a global perspective

Delivery at Term

Genome-wide Analysis of Circular RNAs and Validation of hsa_circ_0086354 As a Promising Biomarker for Early Diagnosis of Cerebral Palsy

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