Multi‐echo GRE imaging of knee cartilage

Yuen, Joanna; Hung, Jachin; Wiggermann, Vanessa; Robinson, Simon; McCormack, Robert G.; d’Entremont, Agnes G.; Rauscher, Alexander

doi:10.1002/jmri.25438

Cited by 5 publications

(6 citation statements)

References 35 publications

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“…Previous studies demonstrated the feasibility of using phase and SWI from the 3D multiecho GRE scan to visualize abnormalities of the human articular cartilage. 21 Phase contrast variation of the veins was observed across the human epiphyseal cartilage. 22 Magnetic susceptibility variation was also observed at different depths in the adult cartilage at 7T.…”

Section: Discussionmentioning

confidence: 99%

“…3D GRE signal phase has proven to be highly sensitive to tissue microstructure alterations. Previous studies demonstrated the feasibility of using phase and SWI from the 3D multiecho GRE scan to visualize abnormalities of the human articular cartilage . Phase contrast variation of the veins was observed across the human epiphyseal cartilage .…”

Section: Discussionmentioning

confidence: 99%

“…19,20 Yuen et al used T * 2 and frequency maps derived from the multiecho GRE sequence to visualize healthy and abnormal articular cartilage. 21 Dymerska et al reported that susceptibility-weighted imaging (SWI) and QSM allowed in vivo visualization of veins and layers in human growth cartilage. 22 Wei et al demonstrated the feasibility of QSM for quantifying the magnetic susceptibility of collagen fibers at different depths in the articular cartilage.…”

mentioning

confidence: 99%

“…Nissi et al used QSM to improve the visualization of cartilage canals in porcine epiphyseal growth cartilage ex vivo and in vivo . Yuen et al used

{normalT}_{2}^{*}

and frequency maps derived from the multiecho GRE sequence to visualize healthy and abnormal articular cartilage . Dymerska et al reported that susceptibility‐weighted imaging (SWI) and QSM allowed in vivo visualization of veins and layers in human growth cartilage .…”

mentioning

confidence: 99%

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Quantitative susceptibility mapping of articular cartilage in patients with osteoarthritis at 3T

Wei

Lin

Qin

et al. 2018

Magnetic Resonance Imaging

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Background Quantitative susceptibility mapping (QSM) has recently been applied in humans to quantify the magnetic susceptibility of collagen fibrils in the articular cartilage. Purpose To determine the ability of QSM to detect cartilage matrix degeneration between normal and early knee osteoarthritis (OA) patients. Study Type Prospective. Population Twenty‐four patients with knee OA and 24 age‐ and sex‐matched healthy controls. Field Strength/Sequence 3D gradient echo, T1 turbo spin echo, and proton density‐weighted (PDw) spectral attenuated inversion recovery (SPAIR) sequence at 3.0T. Assessment Scan–rescan reproducibility of the susceptibility values in the cartilage was assessed in control subjects. Cartilage thickness, volume, mean, and standard deviation (SD) of susceptibility values of the cartilage compartments were compared between normal and OA patients. The relationship between magnetic susceptibility values and cartilage lesion grading based on MR images was studied. Statistical Tests The Wilcoxon Rank‐Sum test was used to compare cartilage thickness, volume, mean, and SD of susceptibility values between control subjects and OA patients. A Spearman rank correlation was performed to study the relationship between the mean and SD of susceptibility values and the cartilage thinning grades. Results The SD of magnetic susceptibility values in the knee cartilage was significantly lower in OA patients compared with healthy controls, and it decreased with more severe MR grades of cartilage thinning degeneration. Significant correlations between the SD of susceptibility values and cartilage thinning grades were observed with R2 = 0.64 and P = 0.000, R2 = 0.47 and P = 0.002, R2 = 0.52 and P = 0.001, R2 = 0.42 and P = 0.0006, and R2 = 0.67 and P = 0.000 for medial femoral condyle (MFC), lateral femoral condyle (LFC), medial tibia (MT), lateral tibia (LT), and patella, respectively. No significant difference was found in cartilage volume (P = 0.17, P = 0.13, P = 0.20, P = 0.25, and P = 0.18 for MFC, LFC, MT, LT, and patella, respectively) and thickness (P = 0.31, P = 0.19, P = 0.16, P = 0.09, and P = 0.22 for MFC, LFC, MT, LT, and patella, respectively) between OA patients and healthy controls. Data Conclusion The variations of susceptibility values in the knee cartilage decrease with the degree of cartilage degeneration. QSM may be a sensitive indicator for alteration of the collagen network and shows potential to detect cartilage degeneration at early stage. Level of Evidence: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…Nissi et al used QSM to improve the visualization of cartilage canals in porcine epiphyseal growth cartilage ex vivo and in vivo . Yuen et al used

{normalT}_{2}^{*}

mentioning

confidence: 99%

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Quantitative susceptibility mapping of articular cartilage in patients with osteoarthritis at 3T

Wei

Lin

Qin

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…In the follow-up of patients with cartilage repair surgeries, it is important to be able to image the reorganization of the collagen fiber network noninvasively. Phase-based MRI may contribute to the assessment that is currently typically performed with zonal T 2 variation analysis, as it has been shown to do in patients with chondral damage (28).…”

Section: Discussionmentioning

confidence: 99%