Effects of Hormone Therapy on Oxidative Stress in Postmenopausal Women with Metabolic Syndrome

Sánchez-Rodrı́guez, Martha A.; Zacarías-Flores, Mariano; Castrejón-Delgado, Lizett; Ruiz-Rodríguez, Ana Karen; Mendoza-Núñez, Vı́ctor Manuel

doi:10.3390/ijms17091388

Cited by 16 publications

(13 citation statements)

References 42 publications

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“…Likewise, a cross-sectional study from Japan with 100 on average 59-year-old patients with type 2 diabetes observed significantly higher D-ROM levels in women than men 27. A hormone replacement therapy (HRT) may be considered after a thorough risk-benefit evaluation for each individual perimenopausal or postmenopausal woman with T2DM who is experiencing high OS because there is evidence from many clinical trials that HRT is effective in lowering various OS biomarkers 28–30…”

Section: Discussionmentioning

confidence: 99%

Factors associated with high oxidative stress in patients with type 2 diabetes: a meta-analysis of two cohort studies

Anusruti

Yang

Gào

et al. 2020

BMJ Open Diab Res Care

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ObjectiveOur objective is to identify the potential factors associated with serum Diacron’s reactive oxygen metabolites test (D-ROM) levels of patients with type 2 diabetes mellitus (T2DM) by conducting cross-sectional and longitudinal analyses in two large cohorts and further strengthening these results by performing a meta-analysis.MethodsSerum D-ROM concentrations were measured in 1045 and 1101 patients with T2DM from two independent cohort studies from Germany at baseline and repeatedly 3–4 years later. The cross-sectional and longitudinal associations of various potential determinants with D-ROM levels were assessed with a backwards selection algorithm in multivariable adjusted models.ResultsIn the meta-analysis of the cross-sectional analysis, female sex, low education, obesity, smoking, high total cholesterol, hemoglobin A1c ≥7%, no diabetes medication, a history of myocardial infarction, heart failure, a history of cancer and C reactive protein levels (CRP) >3 mg/L were statistically significantly associated with increased D-ROM levels in patients with T2DM. The meta-analysis of the longitudinal analysis revealed that old age, female sex, obesity, smoking, physical inactivity, high alcohol consumption, ≥5 years since diabetes diagnosis and CRP levels between 3 mg/L and 10 mg/L were statistically significantly associated with D-ROM levels measured 3–4 years later.Conclusions (validity, limitations and clinical applicability)This comprehensive analysis confirmed that several modifiable risk factors are being associated with oxidative stress in patients with T2DM within an observational study design. We discuss potential prevention measures against these risk factors that might help to reduce oxidative stress and to prevent some cases of premature mortality in patients with T2DM.

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Section: Discussionmentioning

confidence: 99%

Factors associated with high oxidative stress in patients with type 2 diabetes: a meta-analysis of two cohort studies

Anusruti

Yang

Gào

et al. 2020

BMJ Open Diab Res Care

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“… 56 Hormone therapy improves the lipid and oxidative alterations that occur in MetS in post-menopausal women. 57 Cumulative alcohol consumption may be an especially important confounding factor. Our previous study found that an ‘alcohol’ dietary pattern was present in Chinese men.…”

Section: Discussionmentioning

confidence: 99%

Relationship between dietary factors and the number of altered metabolic syndrome components in Chinese adults: a cross-sectional study using data from the China Health and Nutrition Survey

Cheng

Wang

et al. 2017

BMJ Open

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ObjectivesTo study the correlation between dietary factors and the number of altered metabolic syndrome components (MetS) in Chinese adults systematically.SettingA cross-sectional study using demographic and dietary data of adults aged 18–75 years from the China Health and Nutrition Survey (2009) was conducted in nine provinces in China.ParticipantsThere were 6034 eligible subjects (2800 men and 3234 women) in this study.OutcomesThe primary outcome of this study were diet assessments and the number of altered MetS components. Dietary intake was measured using a combination of a 3-day period with 24-hour and household food inventory; average daily intakes of nutrients were estimated according to the Chinese Food Composition Table. Blood samples were analysed in a national central laboratory and the number of clustering MetS components was calculated by adding the presence of each MetS component.ResultsAfter adjusting for covariates, and taking zero MetS as comparison, the high risk factors correlating with increased numbers of altered MetS components in men were higher intake of protein (70.4–73.4 g; Ptrend=0.0004), cholesterol (238.7–266.6 mg; Ptrend=0.004), meat (90.6–105.7 g; Ptrend=0.016), fish/seafood (30.4–42.3 g; Ptrend=0.001), and lower intake of coarse cereals (16.5–12.7 g; Ptrend=0.051), tubers (37.3–32.7 g; Ptrend=0.030), and dietary fibre (11.7–11.5 g; ANCOVA p=0.058). Meanwhile, the high risk factors correlating with the increased number of altered MetS components in women were higher intake of wheat (101.9–112.6 g; Ptrend=0.066) and sodium (3862.3–4005.7 mg, Ptrend=0.032), and lower intake of β-carotene (1578.6–1382.7 µg; Ptrend=0.007), milk, and dairy products (17.8–11.5 g; Ptrend=0.002).ConclusionsSome foods and nutritional factors correlate with an increased number of altered MetS components in Chinese adults. More prospective, multicentre and clinical research work to further examine these associations is underway.

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“…2 Oxidative stress increases in postmenopausal females. 3 This is because of decreasing levels of estrogens as it acts as direct scavenger of free radicals. 4 The increased oxidative stress in postmenopausal females results in heart diseases, vasomotor disturbances and osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Nigella Sativa on Oxidative Stress in Post-Menopausal Females

Sana

Saeed

Umair

2019

JIMDC

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Background: The permanent cessation of menstrual periods in menopause causes a decline in estrogen levels and increased oxidative stress. Both of these factors lead to menopausal symptoms, cardiovascular diseases and osteoporosis in the postmenopausal females that negatively affect the quality of their lives. Antioxidant properties of Nigella sativa are due to its natural ingredient “thymoquinone” and have been studied in various animal and human studies. This study was done to determine beneficial effect of nigella sativa. Material and Methods: Thirty postmenopausal females were recruited in the study after taking consent. Nigella sativa was administered at a dose of 1g/day for 2 months after breakfast. Blood sample was taken for pre and post treatment glutathione (GSH) estimation. The SPSS version 21 was used to analyze the data. Paired t- test was applied. P value of< 0.05 was considered significant.Results: Regarding the effect of the Nigella sativa on oxidative stress, result indicated a highly significant increase from baseline (p<0.0001) after 8 weeks’ consumption of Nigella sativa. The effect size was calculated both for biochemical parameter GSH and general parameter like weight and BMI. The result of the effect size calculation showed larger effect size for GSH levels (3.9) and moderate sized effect for weight and BMI.Conclusion: Nigella Sativa showed beneficial antioxidant effects in post-menopausal females and might be responsible for a better quality of life in these women.

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Effects of Hormone Therapy on Oxidative Stress in Postmenopausal Women with Metabolic Syndrome

Cited by 16 publications

References 42 publications

Factors associated with high oxidative stress in patients with type 2 diabetes: a meta-analysis of two cohort studies

Factors associated with high oxidative stress in patients with type 2 diabetes: a meta-analysis of two cohort studies

Relationship between dietary factors and the number of altered metabolic syndrome components in Chinese adults: a cross-sectional study using data from the China Health and Nutrition Survey

Effect of Nigella Sativa on Oxidative Stress in Post-Menopausal Females

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