Current concepts of essential tremor

Gövert, Felix; Becktepe, Jos S.; Deuschl, Günther

doi:10.1016/j.neurol.2016.07.010

Cited by 12 publications

(9 citation statements)

References 73 publications

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“…[3]. Im Gegensatz zu früheren Arbeiten wird aktuell nicht mehr von einem einzigen Oszillator ausgegangen, sondern von mehreren Neuronengruppen, die möglicherweise alternierend oszillieren im Sinne eines dynamischen Netzwerkes [9]. Das GABA-erge System soll in der Ätiologie des ET involviert sein [10].…”

Section: Therapieunclassified

“…Das GABA-erge System soll in der Ätiologie des ET involviert sein [10]. Die Pathophysiologie der kognitiven Symptome ist nur limitiert verstanden, aktuell werden Dysfunktionen im Bereich des präfrontalen und parietalen Kortex vermutet [9].…”

Section: Therapieunclassified

“…Histopathologisch sind die Daten uneinheitlich und ergeben kein zielführendes Bild, so wurden Verlust und eine axonale Veränderung der Purkinje-Zellen im Kleinhirn und ein Zellverlust im Locus coeruleus beschrieben. Diese Befunde können allerdings nicht nur Ursache, sondern auch Folge im Sinne einer sekundären Schädigung nach einer langjährigen neuronalen oszillatorischen Aktivität sein [4,9].…”

Section: Therapieunclassified

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Diagnostik und Therapie von Tremorsyndromen

Bârlescu¹,

Kassubek²

2020

Neuro u2d

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Section: Therapieunclassified

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Diagnostik und Therapie von Tremorsyndromen

Bârlescu¹,

Kassubek²

2020

Neuro u2d

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“…Theories on the pathophysiology of ET include the neurodegenerative, GABAergic and oscillatory network hypotheses [60]. For patients with ET, there is no postmortem gold standard for histopathological confirmation of the diagnosis, as it is in PD [61].…”

Section: Pathophysiology Of Parkinsonian and Non-parkinsonian Tremormentioning

confidence: 99%

Rest tremor revisited: Parkinson’s disease and other disorders

Chen

Hopfner

Becktepe

et al. 2017

Transl Neurodegener

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Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is challenging to make an accurate diagnosis. This applies particularly for tremor at rest. This entity was only rarely studied in the past, although a multitude of clinical studies on prevalence and clinical features of tremor in Parkinson’s disease (PD), essential tremor and dystonia, have been carried out. Monosymptomatic rest tremor has been further separated from tremor-dominated PD. Rest tremor is also found in dystonic tremor, essential tremor with a rest component, Holmes tremor and a few even rarer conditions. Dopamine transporter imaging and several electrophysiological methods provide additional clues for tremor differential diagnosis. New evidence from neuroimaging and electrophysiological studies has broadened our knowledge on the pathophysiology of Parkinsonian and non-Parkinsonian tremor. Large cohort studies are warranted in future to explore the nature course and biological basis of tremor in common tremor related disorders.

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“…It is characterised by a postural and kinetic tremor of the arms and other parts of the body; its progression is slow but can lead to an impairment of the activities the patient plays in a typical day at home and at work 1. The primary cause and the pathogenesis of the symptoms are unknown.…”

Section: Introductionmentioning

confidence: 99%

High-dose thiamine and essential tremor

Costantini¹

2018

BMJ Case Reports

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Essential tremor is a common neurological disease. The medical treatment of this affection currently involves the use of propranolol, primidone and other drugs. These drugs, however, are often not effective in reducing tremor and cause side effects in a large share of the patients treated. The treatment with intramuscular high-dose thiamine has led to a rapid, remarkable and persistent improvement of the symptoms in two patients with essential tremor. This result suggests the possibility that high doses of intramuscular thiamine may be an affordable alternative, highly effective and long-lasting medical treatment that has shown no relevant side effect.

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Current concepts of essential tremor

Cited by 12 publications

References 73 publications

Diagnostik und Therapie von Tremorsyndromen

Diagnostik und Therapie von Tremorsyndromen

Rest tremor revisited: Parkinson’s disease and other disorders

High-dose thiamine and essential tremor

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