Prognostic value of the albumin–bilirubin grade in patients with hepatocellular carcinoma: Validation in a Chinese cohort

Abstract

The ALBI grade, which was featured by simplicity and objectivity, gained a superior prognostic value than that of C-P grade in patients with hepatocellular carcinoma who underwent liver resection. Future well-designed studies with larger sample sizes are warranted.

Prognostic utility of albumin‐bilirubin grade for short‐ and long‐term outcomes following hepatic resection for intrahepatic cholangiocarcinoma: A multi‐institutional analysis of 706 patients

“…Apart from long‐term survival, the ALBI grade has also been associated with perioperative outcomes . A recent analysis of the National Surgical Quality Improvement Program database from our own group revealed that ALBI grade 2/3 was associated with higher odds of posthepatectomy liver failure (PHLF; OR = 1.57, 95% CI, 1.08‐2.27), bile leak (OR = 1.35; 95% CI, 1.02‐1.80), perioperative transfusion (OR = 2.08; 95% CI, 1.69‐2.55), and 30‐day mortality (OR = 2.40; 95% CI, 1.25‐4.60) following liver surgery for benign and malignant diseases .…”

Prognostic significance of combined albumin–bilirubin and tumor–node–metastasis staging system in patients who underwent hepatic resection for hepatocellular carcinoma

“…The ALBI score was established by a training cohort of 1313 Japanese patients with HCC. Some reports were published that the ALBI score was superior for distinguishing patients with better hepatic function . The ALBI score is a simple liver function assessment score because it requires only two parameters, serum albumin and bilirubin, which means that the prognosis could be predicted in any institute or for any modality such as surgery, transarterial chemoembolization, and radiofrequency ablation.…”

“…Similarly, the modified JIS score is the sum of points for two variables of liver damage grade classification and the Japanese TNM classification . The ALBI score is a simple and objective measure of liver function and is applicable to HCC at all stages of chronic liver disease unlike the Child–Pugh score that is conventionally restricted to patients with cirrhosis . It is based on serum bilirubin and albumin and was derived from, and subsequently validated by, rigorous statistical analysis of over 6000 patients with HCC.…”

“…In recent years, the establishment of new staging systems for hepatocellular carcinoma (HCC) has been reported worldwide. Albumin–bilirubin (ALBI) combined with the tumor–node–metastasis (TNM) staging classification of the Liver Cancer Study Group of Japan, was called the ALBI‐T score . Unlike other solid tumors, the prognosis and treatment for patients with HCC depends not only on tumor stage, but also liver function.…”

“…Some reports have compared ALBI‐T and CLIP or BCLC staging, but there are no reports comparing JIS, modified JIS, and ALBI‐T. In this retrospective study, we compared JIS, modified JIS, and the ALBI‐T score for predicting prognosis in patients with HCC treated by hepatic resection.…”