Association of vitamin D receptor gene polymorphisms with susceptibility to childhood asthma: A meta‐analysis

Zhao, Dongdong; Yu, Dandan; Ren, Qiongqiong; Dong, Bin; Zhao, Feng; Sun, Yehuan

doi:10.1002/ppul.23548

Cited by 36 publications

(38 citation statements)

References 33 publications

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“…In the past few years, research on the correlation between VDR and asthma has focused on four SNPs: ApaI, FokI, BsmI and TaqI. Our meta-analysis showed that ApaI, FokI, and BsmI polymorphisms contribute to childhood asthma susceptibility, while there was no evidence of the association between TaqI SNP and pediatric asthma risk, which con rms the previous research results 70 . And we found that ApaI and BsmI polymorphisms may be associated with asthma in Asian populations.…”

Section: Sensitivity Analysis and Publication Biassupporting

confidence: 86%

Asthma susceptible genes in children: A meta-analysis

Ruan

Shi

Zhang

et al. 2020

Preprint

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Background: During the last decade, a number of studies have evaluated the potential association between some genetic polymorphisms and childhood asthma risk, however, the results of published studies appeared conflicts. The aim of the present study was to investigate association between genetic polymorphisms and pediatric asthma. Methods: Relevant studies were searched in PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang and Weipu database. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to access the strength of the associations. Results: 45 case-control studies were finally included in this meta-analysis. Eighteen SNPs were identified. Ten polymorphisms were found to be associated with asthma risk: IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4, ORMDL3 rs7216389, VDR ApaⅠ, VDR FokⅠ, VDR BsmⅠ. After subgroup analysis, IL-13 +2044G/A, ADAM33 T2, ADAM33 T1, VDR ApaⅠ, VDR BsmⅠ polymorphisms were associated with increased risk of asthma among Asian populations. IL-4 -590C/T polymorphisms may be related to asthma risk in Chinese children.Conclusions: This meta-analysis found that IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4, ORMDL3 rs7216389, VDR ApaⅠ, VDR FokⅠ and VDR BsmⅠ polymorphisms might be risk factors for childhood asthma. Further study with large population and more ethnicities is needed to estimate the associations.

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Section: Sensitivity Analysis and Publication Biassupporting

confidence: 86%

Asthma susceptible genes in children: A meta-analysis

Ruan

Shi

Zhang

et al. 2020

Preprint

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“…Of the four SNPs identified, Apal polymorphism is believed to play a role in childhood asthma in Asians, Fokl polymorphism may relate to pediatric asthma in Caucasians, Bsml polymorphisms marginally contributes to susceptibility of childhood asthma and no association was found between Taql and risk of pediatric asthma. 41 …”

Section: Childrenmentioning

confidence: 99%

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

Hall

Agrawal

2017

Clinical Therapeutics

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Vitamin D is a potent immunomodulator capable of dampening inflammatory signals in several cell types involved in the asthmatic response. Its deficiency has been associated with increased inflammation, exacerbations and overall worse outcomes in patients with asthma. Given the increase in the prevalence of asthma over the last few decades, there has been enormous interest in the use of vitamin D supplementation as a potential therapeutic option. Several studies have found that low serum levels of vitamin D (< 20 ng/ml) are associated with increased exacerbations, increased airway inflammation, decreased lung function and poor prognosis in asthmatic patients. Results from the in vitro and in vivo studies in animals and human have suggested that supplementation with vitamin D can ameliorate several hallmark features of asthma. However, the findings obtained from clinical trials are controversial and do not unequivocally support the beneficial role of vitamin D in asthma. Largely, interventional studies in children, pregnant women and adults have primarily found little-to-no effect of vitamin D supplementation on improved asthma symptoms, onset or progression of the disease. This could be related to the severity of the disease process and other confounding factors. Despite the conflicting data obtained from clinical trials, vitamin D deficiency does influence the inflammatory response in the airways. Further studies are needed to determine the exact mechanisms by which vitamin D supplementation may induce anti-inflammatory effects. Here, we critically reviewed the most recent findings from in vitro studies, animal models, and clinical trials regarding the role of vitamin D in bronchial asthma.

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“…In addition, they have reported that FokI polymorphism may be connected with pediatric asthma in Caucasian population and BsmI polymorphism marginally contributes to childhood asthma susceptibility. 27 In another meta-analysis evaluating 8 case-control studies, FokI, TaqI, and BsmI VDR polymorphisms were significantly associated with an increased risk of asthma in some populations. In this meta-analysis, the authors suggested that serum 25(OH)D levels and various environmental factors could modify the effect of these polymorphisms on asthma development.…”

Section: Discussionmentioning

confidence: 99%

The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study

Kılıç

Ecin

Taşkın

et al. 2019

Pediatric Allergy, Immunology, and Pulmonology

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Background: The association between vitamin D receptor (VDR) polymorphisms and the risk of asthma remains unclear. This study aimed to investigate the effect of VDR gene polymorphisms and VDR mRNA expression levels on respiratory function, nitric oxide levels in expiratory air, and serum vitamin D levels in children with asthma. Materials and Methods: The study included 80 healthy children (control group) and 100 asthmatic children (asthma group) between the age of 5 and 18 years. The VDR genotypes (ApaI, TaqI, and FokI) and VDR mRNA levels were determined in all groups. Results: There was no statistically significant difference in vitamin D levels between the asthma group and the control group (P > 0.05). A significant association was found between both genotype (CC) of the TaqI polymorphism [odds ratio (OR) = 0.2, 95% confidence interval (CI) (0.07-0.5), P = 0.003] and genotype (CA) of ApaI polymorphisms [OR = 0.2, 95% CI (0.07-0.8), P = 0.02], and asthma risk. In addition, when singlenucleotide polymorphism allelic frequencies between asthma and control groups were compared there is no significant association (P > 0.05). When compared to control group, VDR mRNA expression in asthma group decreased in genotypes CC and CA of ApaI and in genotypes TT and TC of TaqI (P < 0.05). Conclusion: The results provide supporting evidence for an association between TaqI and ApaI polymorphisms and asthma susceptibility.

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Association of vitamin D receptor gene polymorphisms with susceptibility to childhood asthma: A meta‐analysis

Cited by 36 publications

References 33 publications

Asthma susceptible genes in children: A meta-analysis

Asthma susceptible genes in children: A meta-analysis

Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years

The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study

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