Aspirin for Primary and Secondary Prevention of Cardiovascular Disease

Godley, Robert W.; Hernandez-Vila, Eduardo A.

doi:10.14503/thij-16-5807

Cited by 16 publications

(11 citation statements)

References 8 publications

(1 reference statement)

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“…Some recent studies also suggested that aspirin may have protective effects against cancer; a disease that affects all communities and contributes substantially to the global disease burden by impinging on the lives of tens of millions of individuals each year (Global Burden of Disease Cancer Collaboration, 2019). Moreover, there is extensive evidence about the benefits of aspirin use for the secondary prevention against cardiovascular diseases (Godley and Hernandez-Vila, 2016).…”

Section: Introductionmentioning

confidence: 99%

Influence of Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study

et al. 2020

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Background: Despite the wide benefits of aspirin and its cost-effectiveness, aspirin prescriptions have been reduced due to idiosyncratic responses in susceptible individuals. Low-dose aspirin and single-nucleotide polymorphisms (SNPs) are independently associated with increased risk of gastrointestinal hemorrhage; however, to-date, no studies investigated the SNP-aspirin interaction effect on upper gastrointestinal hemorrhage (UGIH). Therefore, we aimed to evaluate the role of 25 SNPs in multiple genes involved in platelet activation, angiogenesis and inflammatory response in aspirin-related UGIH. Methods: A multicenter, full case-control study was conducted in patients exposed and unexposed to aspirin. Three hundred twenty-six cases diagnosed with UGIH were matched with 748 controls (1:3) by age, gender, health center, and recruitment date. Only adults of European origin were included. Participants were stratified by aspirin exposure and genotype [(Aspirin (−) , wild-type), (Aspirin (+) , wild-type), (Aspirin (+) , genetic variation), (Aspirin (−) , genetic variation)]. For each SNP, the Odds Ratio of UGIH and their 95% confidence intervals were estimated in each subgroup by using the generalized linear mixed models for dependent binomial variables. SNP-aspirin interaction effect was estimated through Relative Excess Risk due to Interaction (RERI) measures.

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Section: Introductionmentioning

confidence: 99%

Influence of Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study

et al. 2020

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“…Dissolution studies of EZT-ASA system confirmed that the occurrence of eutectic in binary drug-drug mixtures prepared by grinding leads to an enhancing of solubility and dissolution rate of the ingredients, which may significantly affect the bioavailability of APIs in fixed-dose combinations. Since EZT and ASA doses are in the range of 10-20 mg and 75-162 mg [42], respectively, and the best released EZT-ASA mixtures contain 10-30 mass% of EZT, results of our studies make it possible the development of a single dosage form containing two APIs in a suitable therapeutic amount.…”

Section: Discussionmentioning

confidence: 97%

Physicochemical and dissolution properties of ezetimibe–aspirin binary system in development of fixed-dose combinations

Gòrniak

Czapor-Irzabek

Złocińska

et al. 2020

J Therm Anal Calorim

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The objective of this work was to investigate binary pharmaceutical mixtures of ezetimibe (EZT) and aspirin (ASA) in order to identify whether the occurrence of eutectic in this system has an effect on EZT dissolution improvement. Ezetimibeaspirin (EZT-ASA) solid dispersions prepared by grinding in the whole range of compositions were characterized using differential scanning calorimetry (DSC) for purpose to describe solid-liquid phase equilibrium diagram. The occurrence of interactions between ingredients was excluded by Fourier transform infrared spectroscopy and X-ray powder diffractometry. Dissolution studies have shown that the mixtures containing from 10 to 60 mass% of EZT (53.5 mass% of EZT in eutectic composition) have released ezetimibe faster than a sample of pure drug. Moreover, ASA is released more quickly from all obtained dispersions than from powder alone. Our studies have shown that obtained mixtures are useful to obtain the fixeddose combinations, capable to deliver these two APIs together in a single system with enhanced dissolution of EZT and ASA.

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“…Because of the prominent role of thrombosis in the pathogenesis of SA, aspirin was wildly used for its antithrombotic properties . The cardioprotective benefits of aspirin are probably result from its ability to inhibit the formation of prostaglandins and thromboxane A2 . MPs shed from apoptotic or peripheral blood cells or activated vascular, which contain complex procoagulant properties .…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that: aspirin can inhibit the formation of prostaglandins and thromboxane A 2 (promote platelet aggregation and vasoconstriction by inhibiting of the COX‐1 enzyme irreversibly). And cox‐1 can activate platelet …”

Section: Discussionmentioning

confidence: 99%

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Endothelial damage effects of circulating microparticles from patients with stable angina are reduced by aspirin through ERK/p38 MAPKs pathways

Cheng

Shan

Wang

et al. 2017

Cardiovascular Therapeutics

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Aspirin for Primary and Secondary Prevention of Cardiovascular Disease

Cited by 16 publications

References 8 publications

Influence of Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study

Influence of Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study

Physicochemical and dissolution properties of ezetimibe–aspirin binary system in development of fixed-dose combinations

Endothelial damage effects of circulating microparticles from patients with stable angina are reduced by aspirin through ERK/p38 MAPKs pathways

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